Mechanisms of combined action of different chemopreventive dietary compounds

Kok, Theo M. de; Breda, Simone G. van; Manson, Margaret M.

doi:10.1007/s00394-008-2006-y

Cited by 250 publications

(165 citation statements)

References 67 publications

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“…There remains the indefinite yet unending possibility that there exists better preventive or therapeutic potential in the synergistic action of these terpenoid molecules. Emerging studies have shown that a combination of phytochemicals may be more effective against cancer than individual components [187][188][189][190][191] . Further studies are needed to explore the full potential of these multifunctional terpenoids in the combinational setting.…”

Section: Resultsmentioning

confidence: 99%

Terpenoids as potential chemopreventive and therapeutic agents in liver cancer

Thoppil

Bishayee²

2011

WJH

267

143

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Despite significant advances in medicine, liver cancer, predominantly hepatocellular carcinoma remains a major cause of death in the United States as well as the rest of the world. As limited treatment options are currently available to patients with liver cancer, novel preventive control and effective therapeutic approaches are considered to be reasonable and decisive measures to combat this disease. Several naturally occurring dietary and non-dietary phytochemicals have shown enormous potential in the prevention and treatment of several cancers, especially those of the gastrointestinal tract. Terpenoids, the largest group of phytochemicals, traditionally used for medicinal purposes in India and China, are currently being explored as anticancer agents in clinical trials. Terpenoids (also called "isoprenoids") are secondary metabolites occurring in most organisms, particularly plants. More than 40 000 individual terpenoids are known to exist in nature with new compounds being discovered every year. A large number of terpenoids exhibit cytotoxicity against a variety of tumor cells and cancer preventive as well as anticancer efficacy in preclinical animal models. This review critically examines the potential role of naturally occurring terpenoids, from diverse origins, in the chemoprevention and treatment of liver tumors. Both in vitro and in vivo effects of these agents and related cellular and molecular mechanisms are highlighted. Potential challenges and future directions involved in the advancement of these promising natural compounds in the chemoprevention and therapy of human liver cancer are also discussed.

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Section: Resultsmentioning

confidence: 99%

Terpenoids as potential chemopreventive and therapeutic agents in liver cancer

Thoppil

Bishayee²

2011

WJH

267

143

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“…It is also important to note that in addition to antioxidant activity, phenolic compounds perform other actions in the organism, such as vasodilator, anti-inflammatory, anti-atherogenic and antithrombotic and also act as modulators of enzymatic pathways, of gene expression, improve the properties of cell membrane and receptors function [13][14][15] .…”

Section: Introductionmentioning

confidence: 99%

Estimate of consumption of phenolic compounds by Brazilian population

et al. 2015

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A B S T R A C T ObjectiveEstimate the intake of phenolic compounds by the Brazilian population. MethodsTo estimate the average per capita food consumption, micro data from the National Dietary Survey and from the Household Budget Survey from 2008 to 2009 was analyzed. The phenolic content in food was estimated from the base of Phenol-Explorer. It was chosen according to compatibility and variety of food items and usual method of preparation. ResultsThe Brazilian population consumed, on average, 460.15 mg/day of total phenolic compounds, derived mainly from beverages (48.9%), especially coffee and legumes (19.5%). Since this analysis of classes of phenolics it was possible to observe an intake of 314 mg/day of phenolic acids, 138.92 mg/day of flavonoids and 7.16 mg/ day of other kinds of phenolics. Regarding the variables studied this present study shows that those men who live in the countryside and in the northeastern region of the country had a higher consumption of phenolic compounds. Besides, consumption was higher by adults and the elderly, the medium income classes, the population with incomplete and complete primary education and those with adequate nutrition and also overweight status. ConclusionThe intake of phenolic compounds can be considered low, especially where consumption of fruit and vegetables is insufficient. We can conclude that coffee and black beans were the best contributors to phenolic intake.

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“…In this context, polyphenols are investigated as promising medicinal agents for the treatment of bacterial infections, ulcer, hypertension, vascular fragility, allergies, hypercholesterolemia and, most notably, various types of cancer. While a number of literature reviews have addressed the anticancer properties of natural polyphenols (see references [1][2][3][4]), targeting protein kinases with these compounds has not received its due attention in the review literature despite a large amount of original research reports indicating that this strategy holds an immense potential for the development of novel cancer therapies. Therefore, the aim of the present review is to fill this gap in the literature by focusing on polyphenols whose anticancer properties are mediated through specific kinase activity inhibition.…”

Section: Introductionmentioning

confidence: 99%

Natural Polyphenols that Display Anticancer Properties through Inhibition of Kinase Activity

Lamoral-Theys¹,

Pottier

Dufrasne³

et al. 2010

CMC

121

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Over eleven hundred publications reporting anticancer activities of polyphenols have appeared in the peerreviewed literature. In addition, a search of the PubMed database using "polyphenols -cancer -review" as keywords produced over 320 hits for review articles (July 2009). Polyphenol anticancer activities include, among others, anti-oxidative, pro-apoptotic, DNA damaging, anti-angiogenic, and immunostimulatory effects. Targeting specific protein kinases to combat cancer represents a major focus of oncology research within the so-called targeted therapy approach. An exhaustive search of the PubMed database (July 2009) using "polyphenols -cancer -kinases" as keywords resulted in more than 130 hits, half of them having been published within the past five years. Furthermore, the PubMed database contains 25 reviews on the subject of anti-kinase activity of some specific polyphenols, including mainly curcumin and the green tea polyphenol (-)-epigallocatechin 3-gallate (EGCG). However, no attempt has been made yet to review this area of research in a comprehensive, general manner. The current review therefore aims to highlight those anticancer polyphenols that target specific kinases in various types of cancer. The present review also provides an in-depth analysis of polyphenol structure-activity relationships in relation to their anticancer activities and specific kinase targeting. Lastly, a number of polyphenols are identified as potential antitumor agents that could be used to combat biologically aggressive cancers, including metastasizing cancers, through the targeting of specific kinases.

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Mechanisms of combined action of different chemopreventive dietary compounds

Cited by 250 publications

References 67 publications

Terpenoids as potential chemopreventive and therapeutic agents in liver cancer

Terpenoids as potential chemopreventive and therapeutic agents in liver cancer

Estimate of consumption of phenolic compounds by Brazilian population

Natural Polyphenols that Display Anticancer Properties through Inhibition of Kinase Activity

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