Mechanisms of association between physical functioning and breast cancer mortality: evidence from the Women’s Healthy Eating and Living Study

Marinac, Catherine R.; Patterson, Ruth E.; Villaseñor, Adriana; Flatt, Shirley W.; Pierce, John P.

doi:10.1007/s11764-013-0334-2

Cited by 14 publications

(25 citation statements)

References 40 publications

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“…The effect of treatment on physical function is an important consideration for all people, but particularly for older adults . Functional decline is associated with loss of independence, greater risk of hospitalization and nursing home placement, and poorer overall survival . In a study of 2,202 women aged 21 to 79, 39% reported one or more functional limitations after a breast cancer diagnosis (9–39 months after diagnosis (average 21 months).…”

Section: Discussionmentioning

confidence: 99%

“…14,15 Functional decline is associated with loss of independence, greater risk of hospitalization and nursing home placement, and poorer overall survival. [16][17][18] In a study of 2,202 women aged 21 to 79, 39% reported one or more functional limitations after a breast cancer diagnosis (9-39 months after diagnosis (average 21 months). In that study, functional limitations increased with age and were associated with poorer overall survival, independent of lifestyle, clinical, or sociodemographic factors.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Functional Decline and Resilience in Older Women Receiving Adjuvant Chemotherapy for Breast Cancer

Hurria

Soto‐Pérez‐de‐Celis

Allred

et al. 2018

J American Geriatrics Society

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Functional Decline and Resilience in Older Women Receiving Adjuvant Chemotherapy for Breast Cancer

Hurria

Soto‐Pérez‐de‐Celis

Allred

et al. 2018

J American Geriatrics Society

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“…13 These observations are important because poor physical function may be associated with premature mortality among survivors of breast cancer. [14][15][16][17] In addition, poor physical function may be associated with injurious falls, bone fracture, and disability among survivors of breast cancer. [18][19][20] Collectively, these observational data suggest that survivors of breast cancer may experience deterioration of physical function and that poor physical function may be associated with adverse health outcomes.…”

Section: Journal Of Clinical Oncology O R I G I N a L R E P O R T V Omentioning

confidence: 99%

Weight Lifting and Physical Function Among Survivors of Breast Cancer: A Post Hoc Analysis of a Randomized Controlled Trial

Brown

Schmitz

2015

JCO

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A B S T R A C T PurposeSurvivors of breast cancer may experience deterioration of physical function. This is important because poor physical function may be associated with premature mortality, injurious falls, bone fracture, and disability. We conducted a post hoc analysis to explore the potential efficacy of slowly progressive weight lifting to reduce the incidence of physical function deterioration among survivors of breast cancer. MethodsBetween October 2005 and August 2008, we conducted a single-blind, 12-month, randomized controlled trial of twice-per-week slowly progressive weight lifting or standard care among 295 survivors of nonmetastatic breast cancer. In this post hoc analysis of data from the Physical Activity and Lymphedema Trial, we examined incident deterioration of physical function after 12 months, defined as a Ն 10-point decrease in the physical function subscale of the Medical Outcomes Short-Form 36-item questionnaire. ResultsThe proportion of participants who experienced incident physical function deterioration after 12 months was 16.3% (24/147) in the control group and 8.1% (12/148) in the weight lifting group (relative risk, 0.49; 95% CI, 0.25 to 0.96; P ϭ .04). No serious or unexpected adverse events occurred that were related to weight lifting. ConclusionSlowly progressive weight lifting compared with standard care reduced the incidence of physical function deterioration among survivors of breast cancer. These data are hypothesis generating. Future studies should directly compare the efficacy of weight lifting with other modalities of exercise, such as brisk walking, to appropriately inform the development of a confirmatory study designed to preserve physical function among survivors of breast cancer.

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“…In 2012, the American cancer society reported 1.7 million cases of breast cancer and 521 900 cases of breast cancer-related death across the world (1). A number of inflammatory markers including Interleukin6 (IL-6), tumor necrosis factor alpha (TNF-α) and C-reactive protein (CRP) increase in breast cancer as well as in several other types of cancers (2)(3)(4). Increased CRP is associated with a risk of death and heart disease in patients with breast cancer (5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Exercise Type on Inflammatory Markers in Obese Survivors With Breast Cancer: Randomized Control Trial

2016

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Mechanisms of association between physical functioning and breast cancer mortality: evidence from the Women’s Healthy Eating and Living Study

Cited by 14 publications

References 40 publications

Functional Decline and Resilience in Older Women Receiving Adjuvant Chemotherapy for Breast Cancer

Functional Decline and Resilience in Older Women Receiving Adjuvant Chemotherapy for Breast Cancer

Weight Lifting and Physical Function Among Survivors of Breast Cancer: A Post Hoc Analysis of a Randomized Controlled Trial

The Effect of Exercise Type on Inflammatory Markers in Obese Survivors With Breast Cancer: Randomized Control Trial

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