Mechanisms of antibacterial drug resistance and approaches to overcome

Valsamatzi-Panagiotou, Aikaterini; Traykovska, Martina; Penchovsky, Robert

doi:10.1016/b978-0-12-818480-6.00002-3

Cited by 4 publications

(3 citation statements)

References 119 publications

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“…It has been a great challenge for the health system worldwide in the last several decades. 1,2 The misuse of antibacterial drugs has increased many multidrug-resistant (MDR) pathogenic bacteria. As a result, many MDR infections become difficult to treat or even untreatable with conventional antibiotics.…”

Section: ■ Introductionmentioning

confidence: 99%

“…3−6 The selection of MDR bacteria, due to the overuse of antibiotics, has developed several mechanisms for defeating the effect of the antibacterial drugs, such as drug efflux through transporting proteins, drug degradation, or enzymatic modification and modification of the receptor for the antibacterial molecule. 1 There are shortages of effective antibiotic therapies and a lack of successful prevention measures. Therefore, there is an increased 7 need to invent more efficient approaches for antibacterial drug development.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Antimicrobial resistance (AR) in bacterial pathogens is associated with high mortality. It has been a great challenge for the health system worldwide in the last several decades. , The misuse of antibacterial drugs has increased many multidrug-resistant (MDR) pathogenic bacteria. As a result, many MDR infections become difficult to treat or even untreatable with conventional antibiotics. − The selection of MDR bacteria, due to the overuse of antibiotics, has developed several mechanisms for defeating the effect of the antibacterial drugs, such as drug efflux through transporting proteins, drug degradation, or enzymatic modification and modification of the receptor for the antibacterial molecule …”

Section: Introductionmentioning

confidence: 99%

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Targeting TPP Riboswitches Using Chimeric Antisense Oligonucleotide Technology for Antibacterial Drug Development

Traykovska

Otcheva

Penchovsky

2022

ACS Appl. Bio Mater.

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Nowadays, the emergence and the transmission of multidrug-resistant pathogenic bacteria are a severe menace mounting a lot of pressure on the healthcare systems worldwide. Many severe outbreaks of bacterial infections have been reported worldwide in recent years. Thus, there is an immediate demand to develop antibiotics. Some riboswitches are potential targets for overcoming bacterial resistance. This paper demonstrates the bacteriostatic effect of an antisense oligonucleotide (ASO) engineered to suppress the growth of pathogenic bacteria such as Listeria monocytogenes by targeting the Thiamine Pyrophosphate (TPP) riboswitch. It does not inhibit the growth of the conditional pathogenic bacteria Escherichia coli, as it lacks the TPP riboswitch, showing the specificity of action of our ASO. It is covalently bonded with the cell-penetrating protein pVEC. We did bioinformatics analyses of the thiamine pyrophosphate riboswitch regarding its role in synthesizing the metabolite thiamine pyrophosphate, which is essential for bacteria. L. monocytogenes is intrinsically resistant to cephalosporins and usually is treated with ampicillin. A dosage of ASO has been established that inhibits 80% of bacterial growth at 700 nM (4.5 μg/mL). Thus, the TPP riboswitch is a valuable antibacterial target.

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Section: ■ Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Targeting TPP Riboswitches Using Chimeric Antisense Oligonucleotide Technology for Antibacterial Drug Development

Traykovska

Otcheva

Penchovsky

2022

ACS Appl. Bio Mater.

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Thiochromene candidates: design, synthesis, antimicrobial potential and in silico docking study

2021

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Emerging Trends and Promises of Nanoemulsions In Therapeutics Of Infectious Diseases

Juneja

Suthar

Pardhi

et al. 2022

Nanomedicine (Lond.)

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Infectious diseases are prevalent and have contributed to high morbidity rates by creating havoc like the COVID-19, 1918 influenza and Black Death (the plague) pandemics. Antimicrobial resistance, adverse effects, the emergence of co-infections and the high cost of antimicrobial therapies are major threats to the health of people worldwide while impacting overall healthcare and socioeconomic development. One of the most common ways to address this issue lies in improving existing antimicrobial drug-delivery systems. Nanoemulsions and their modified forms have been successfully employed for the delivery of antimicrobials to treat infectious diseases. In this article, the authors comprehensively reviewed how nanoemulsion-based formulation systems are shifting the paradigm for therapeutics and diagnosis of infectious diseases.

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Mechanisms of antibacterial drug resistance and approaches to overcome

Cited by 4 publications

References 119 publications

Targeting TPP Riboswitches Using Chimeric Antisense Oligonucleotide Technology for Antibacterial Drug Development

Targeting TPP Riboswitches Using Chimeric Antisense Oligonucleotide Technology for Antibacterial Drug Development

Thiochromene candidates: design, synthesis, antimicrobial potential and in silico docking study

Emerging Trends and Promises of Nanoemulsions In Therapeutics Of Infectious Diseases

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