1986
DOI: 10.1093/carcin/7.7.1065
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Mechanisms of anti-carcinogenesis: the distribution and metabolism of aflatoxin B1 in rainbow trout fed Aroclor 1254

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Cited by 37 publications
(17 citation statements)
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“…The opposite occurs in rainbow trout where the higher efficiency of AFBO production was associated with the high genotoxicity observed in all tissues tested. The highest peak of damage at 4 h in blood correlated well with the higher plasma levels of AFB 1 found in trout at 5 h, as indicated in kinetic studies by Shelton et al (1986). The damage to kidney cells might be due to the excretion of AFB 1 -glucuronide (Loveland et al 1984).…”
Section: Genotoxicitysupporting
confidence: 68%
“…The opposite occurs in rainbow trout where the higher efficiency of AFBO production was associated with the high genotoxicity observed in all tissues tested. The highest peak of damage at 4 h in blood correlated well with the higher plasma levels of AFB 1 found in trout at 5 h, as indicated in kinetic studies by Shelton et al (1986). The damage to kidney cells might be due to the excretion of AFB 1 -glucuronide (Loveland et al 1984).…”
Section: Genotoxicitysupporting
confidence: 68%
“…The induction of CYPIA by compounds such as 0-naphthoflavone (BNF), indole-3-carbinol (W3C), and polychlorinated biphenyls (PCBs) was thought to be the mechanism by which these modulators acted as chemopreventors of AFBI-initiated hepatocarcinogenesis in trout (109,110).…”
Section: Cytochromes P450mentioning
confidence: 99%
“…After input of PCBs into Swedish waters was forbidden, the frequency of the disease decreased drastically. However, it has since been demonstrated that PCBs are not primary carcinogens for fishes, although it has been shown that these substances do function as promoters of neoplastic lesions (Shelton et al 1986). …”
Section: Z Wmentioning
confidence: 99%