Liver anomalies in dab Limanda limanda from the southern North Sea with special consideration given to neoplastic lesions

Kranz, H.; Dethlefsen, Volkert

doi:10.3354/dao009171

Cited by 29 publications

(16 citation statements)

References 15 publications

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“…In the present authors' examination, the fine structure of the hepatocytes in these foci appeared unimpaired and the only changes which they noted were increases in storage materials. The present authors recorded more of these 'foci' in their survey, compared to the number of hepatoeellular adenomas, which is in agreement with the findings of Kranz & Dethlefsen (1990). A possible explanation for the low numbers of hepatocellular adenomas could be that dab die as a result of other causes before these lesions develop.…”

Section: Discussionsupporting

confidence: 93%

“…These findings have parallels in the studies on liver cancers (hepatoma) induced by carcinogens in hatchery-reared rainbow trout, Oncorhynchus mykiss (Walbaum), (Couch 1985). European workers linked the occurrence of pathological changes in livers, which included putative neoplasms, with anthropogenic pollution in the coastal waters and estuaries of the North Sea (Kranz & Peters 1984, 1985Peters et aL 1987;Vethaak 1987;Kranz & Dethlefsen 1990). …”

Section: Introductionmentioning

confidence: 81%

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Histopathological changes in the livers of dab, Limanda limanda (L.)

Bucke

Feist

1993

Journal of Fish Diseases

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The dab, Limanda limanda (L.), is a common species of flatfish found in the shallow waters of the North Sea, particularly in inshore regions. Because of its distribution and habits, it is a useful spceies for investigations into the biological effects of marine pollution; it is also susceptible to certain, easily-deteetable, gross diseases, including a variety of hepatic lesions, some of which are putative neoplasias. Investigations over the past 10 years on the histopathology of dab livers, have revealed that many lesions are associated with parasitic infections or trauma, and others include the presence of basophilic foei and putative adenoma as well as cell storage changes. The significance of these lesions is discussed in relation to other biological and physical data, and the necessity for histological evaluation is emphasized.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 81%

Histopathological changes in the livers of dab, Limanda limanda (L.)

Bucke

Feist

1993

Journal of Fish Diseases

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“…It is interesting to note in this context that extremely low prevalences of pre-neoplastic and neoplastic lesions (<1%) have also been recorded in the common dab (Limanda limanda) from the western Baltic Sea (Lang, unpublished data). This species also show much higher prevalences in various North Sea areas (Kranz and Dethlefsen, 1990;Lang, 2002b).…”

Section: Discussionmentioning

confidence: 99%

“…The majority of studies on liver histopathology in flatfish species in relation to contaminants has been carried out in coastal waters of the USA (e.g., Malins et al, 1985aMalins et al, ,b, 1988Myers et al, 1991Myers et al, , 1992Myers et al, , 1994Myers et al, , 1998aStein et al, 1992;Moore et al, 1997;Stehr et al, 1998) and in the North Sea (e.g., Kranz and Dethlefsen, 1990;Bucke and Feist, 1993;Kö hler, 1990;Kö hler et al, 1992;Lang, 2002b;Stentiford et al, 2003). For the Baltic Sea, there is only limited information available, largely resulting from data generated within the 1994 ICES/BMB Workshop on Fish Diseases and Parasites in the Baltic Sea Bogovski et al, 1999) and some national studies (Bogovski, 1994;Lang and Dethlefsen, 1994;Wiklund and Bylund, 1994).…”

Section: Introductionmentioning

confidence: 99%

Liver histopathology in Baltic flounder (Platichthys flesus) as indicator of biological effects of contaminants

Lang

Wosniok

Baršienė

et al. 2006

Marine Pollution Bulletin

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Results are presented of a study on liver histopathology in Baltic flounder (Platichthys flesus) carried out in 2001 and 2002 in four coastal sampling areas of the Baltic Sea: Kvädö fjärden (Swedish east coast, reference area), Klaipeda-Butinge (Lithuanian coast), Gulf of Gdansk (Polish coast), and Wismar Bay (German coast) within the framework of the EU-funded BEEP project. Liver lesions were diagnosed and categorised using standardised methodologies and, for a spatial and temporal assessment of the prevalence and types of lesions detected, a scoring system was applied, involving the calculation of mean histopathology lesion scores. 83.0% of the 436 female flounder examined (size range: 20-43 cm total length, age range: 2-8 years) were affected by liver lesions, out of which 74.3% were assigned to the category of non-specific, 3.4% to the category of early toxicopathic non-neoplastic, 4.6% to the category of pre-neoplastic and 0.7% to the category of neoplastic lesions. Mean lesions scores were highest in the areas at the Lithuanian and Swedish coast and there is indication of an impact of the age structure of the flounder populations studied, the sampling season as well as of contaminant effects.

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“…Haensly et al 1982. Matthiessen & Roberts 1982, Gardner & Yevich 1988, Kent 1988, Bodamer & Murchelano 1990, Kranz & Dethlefsen 1990 or may be related to experimental intoxications (Hinton et al 1988, Blair et al 1989, Kohler 1989, Holm et al 1991. Further comparative observations in the wild, in ciguatera areas (such as the Pacific and Indian Oceans and the Caribbean Sea), may help to elucidate the effects of ciguatoxins on fish.…”

Section: Discussionmentioning

confidence: 99%

Ultrastructural alterations of cabrilla sea bass Serranus cabrilla liver related to experimental Gambierdlscus toxicus (dinoflagellate) ingestion

González¹,

Brusle²,

Crespo³

1994

Dis. Aquat. Org.

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Ultrastructural effects of dietary Gambjerdiscus toxlcus on the liver of cabrilla sea bass Serranus cabrilla were investigated. No fish treated with G. toxjcus died during the experiment. A marked perisinusoidal and intercellular fibrosis occurred after algal feeding. Microvilli decreased in number and shortened at the sinusoldal and canalicular areas of the hepatocytes. Lipid accumulation was also apparent. A high number of blnucleated cells, nucleolar disorganization and loss of condensed heterochrornatin at the periphery of the nucleus were also found, as well as nuclear pycnosis, dilated rough endoplasrnlc reticulum and swollen mitochondria. Thls work shows that toxins produced by this dinoflagellate may be considered to be harmful to fish through diet.

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Liver anomalies in dab Limanda limanda from the southern North Sea with special consideration given to neoplastic lesions

Cited by 29 publications

References 15 publications

Histopathological changes in the livers of dab, Limanda limanda (L.)

Histopathological changes in the livers of dab, Limanda limanda (L.)

Liver histopathology in Baltic flounder (Platichthys flesus) as indicator of biological effects of contaminants

Ultrastructural alterations of cabrilla sea bass Serranus cabrilla liver related to experimental Gambierdlscus toxicus (dinoflagellate) ingestion

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