Mechanisms of Aging

Yaar, Mina; Eller, Mark S.

doi:10.1001/archderm.138.11.1429

Cited by 29 publications

(19 citation statements)

References 54 publications

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“…The observed age-related changes in fibroblasts include cell morphology, metabolism [19], reduced proliferative potential [19], [22], [23], loss of responsiveness to growth factors [24], decline in the production of extracellular matrix proteins such as type I and III collagens [25], and overexpression of proteases involved in the degradation of the extracellular matrix [26]. Reduction of telomere length [27], accumulation of free radical-induced DNA damages, and decrease of DNA repair [28], are molecular mechanisms associated with and promoting senescence. The above described modifications of fibroblast properties observed throughout serial in vitro expansion may all more or less participate to the in vivo age-related changes of the skin.…”

Section: Introductionmentioning

confidence: 99%

Aging Alters Functionally Human Dermal Papillary Fibroblasts but Not Reticular Fibroblasts: A New View of Skin Morphogenesis and Aging

et al. 2008

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Understanding the contribution of the dermis in skin aging is a key question, since this tissue is particularly important for skin integrity, and because its properties can affect the epidermis. Characteristics of matched pairs of dermal papillary and reticular fibroblasts (Fp and Fr) were investigated throughout aging, comparing morphology, secretion of cytokines, MMPs/TIMPs, growth potential, and interaction with epidermal keratinocytes. We observed that Fp populations were characterized by a higher proportion of small cells with low granularity and a higher growth potential than Fr populations. However, these differences became less marked with increasing age of donors. Aging was also associated with changes in the secretion activity of both Fp and Fr. Using a reconstructed skin model, we evidenced that Fp and Fr cells do not possess equivalent capacities to sustain keratinopoiesis. Comparing Fp and Fr from young donors, we noticed that dermal equivalents containing Fp were more potent to promote epidermal morphogenesis than those containing Fr. These data emphasize the complexity of dermal fibroblast biology and document the specific functional properties of Fp and Fr. Our results suggest a new model of skin aging in which marked alterations of Fp may affect the histological characteristics of skin.

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Section: Introductionmentioning

confidence: 99%

Aging Alters Functionally Human Dermal Papillary Fibroblasts but Not Reticular Fibroblasts: A New View of Skin Morphogenesis and Aging

et al. 2008

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“…Skin aging manifests as wrinkles, diminished structural integrity and impaired wound healing due to alterations in the remodeling process of the extracellular matrix (ECM). Collagen and elastin impart strength and their degeneration with the passing of time causes skin to become fragile, and aged in appearance [1][2][3][4] .…”

Section: Introductionmentioning

confidence: 99%

Molecular Basis for the Regenerative Properties of a Secretion of the Mollusk <i>Cryptomphalus aspersa</i>

Brieva¹,

Philips

Tejedor

et al. 2007

Skin Pharmacol Physiol

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A screen for natural products bearing pharmacological properties has yielded a secretion of the mollusk Cryptomphalus aspersa (SCA), which possesses skin-regenerative properties. In this report, we outline some of the cellular and molecular effects underlying this observation. First, we found that SCA contained antioxidant SOD and GST activities. In addition, SCA stimulated fibroblast proliferation and rearrangement of the actin cytoskeleton. Additional mechanisms involved in the regenerative effect of SCA included the stimulation of extracellular matrix assembly and the regulation of metalloproteinase activities. Together, these effects provide an array of molecular mechanisms underlying SCA-induced cellular regeneration and postulate its use in regeneration of wounded tissue.

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“…5 In addition, the levels of certain tissue inhibitors of MMP have been shown to be reduced in both photoaged and chronologically aged skin. 5,6 While studying the efficacy of topical imiquimod in biopsy-proven LM, an in situ melanoma that occurs almost exclusively in photodamaged skin, we noted that in addition to the high treatment success rate, imiquimod appeared to reverse some of the histopathologic signs of photoaging. Posttreatment biopsy specimens revealed significant reduction in solar elastosis with normalization of epidermal thickness and papillary dermal fibroplasia compared with pretreatment specimens.…”

Section: Discussionmentioning

confidence: 94%