Arch Dermatol
 2002
DOI: 10.1001/archderm.138.11.1429
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Mechanisms of Aging

Mina Yaar1,
Mark S. Eller2
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Cited by 45 publications

(20 citation statements)
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“…5 In addition, the levels of certain tissue inhibitors of MMP have been shown to be reduced in both photoaged and chronologically aged skin. 5,6 While studying the efficacy of topical imiquimod in biopsy-proven LM, an in situ melanoma that occurs almost exclusively in photodamaged skin, we noted that in addition to the high treatment success rate, imiquimod appeared to reverse some of the histopathologic signs of photoaging. Posttreatment biopsy specimens revealed significant reduction in solar elastosis with normalization of epidermal thickness and papillary dermal fibroplasia compared with pretreatment specimens.…”
Section: Discussionmentioning
confidence: 94%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…5 In addition, the levels of certain tissue inhibitors of MMP have been shown to be reduced in both photoaged and chronologically aged skin. 5,6 While studying the efficacy of topical imiquimod in biopsy-proven LM, an in situ melanoma that occurs almost exclusively in photodamaged skin, we noted that in addition to the high treatment success rate, imiquimod appeared to reverse some of the histopathologic signs of photoaging. Posttreatment biopsy specimens revealed significant reduction in solar elastosis with normalization of epidermal thickness and papillary dermal fibroplasia compared with pretreatment specimens.…”
Section: Discussionmentioning
confidence: 94%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Photo-aged skin is characterized by mottled, irregular areas of pigmentation and hyper-pigmented lesions such as actinic lentigines in sun-exposed areas [27] , [30] , [32] . It is well known that skin photo-aging is also associated with profound alterations of the dermis and dermal fibroblasts [43] , [51] , [62] , [63] . To investigate the influence of chronically photo-exposed fibroblasts on pigmentation, we compared epidermis reconstructed on dermal equivalents containing fibroblasts from photo-aged skin (3 different strains, donors aged over 70 yrs of age) with reconstructed skin samples containing fibroblasts from young, unexposed skin (16–21 yrs old, 3 strains).…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…With such clonally derived senescent cells, a certain fraction still maintains the capacity to proliferate, while other cells have entered a state of irreversibly arrested growth. This heterogeneity results in morphological and growth-rate variability, as well as differing responsiveness to signals and stochastic discrepancies in gene expression . In particular, this clonal heterogeneity is understood to substantially hinder the study of cellular aging .…”
mentioning
confidence: 99%
“…This heterogeneity results in morphological and growth-rate variability, as well as differing responsiveness to signals and stochastic discrepancies in gene expression. 7 In particular, this clonal heterogeneity is understood to substantially hinder the study of cellular aging. 8 To fully study replicative senescence and rigorously elucidate mechanisms of cellular aging, isolating the true senescent cells from these heterogeneous clonal populations represents a critical, first step in the study of aging.…”
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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