Imiquimod as an antiaging agent

Metcalf, Sara; Crowson, A. Neil; Naylor, Mark F.; Haque, Raashid; Cornelison, Raymond L.

doi:10.1016/j.jaad.2006.10.034

Cited by 27 publications

(20 citation statements)

References 9 publications

(12 reference statements)

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“…The inflammation induced by imiquimod may aid in the clearance of BCC [30]. Furthermore, imiquimod has been demonstrated to improve photoaging skin by increasing fibroplasia, decreasing elastosis, and restoring pigment [35]. …”

Section: Topical Imiquimod Therapymentioning

confidence: 99%

Nonsurgical Treatment Options for Basal Cell Carcinoma

Lien

Sondak

2011

Journal of Skin Cancer

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Basal cell carcinoma (BCC) remains the most common form of nonmelanoma skin cancer (NMSC) in Caucasians, with perhaps as many as 2 million new cases expected to occur in the United States in 2010. Many treatment options, including surgical interventions and nonsurgical alternatives, have been utilized to treat BCC. In this paper, two non-surgical options, imiquimod therapy and photodynamic therapy (PDT), will be discussed. Both modalities have demonstrated acceptable disease control rates, cosmetically superior outcomes, and short-term cost-effectiveness. Further studies evaluating long-term cure rates and long-term cost effectiveness of imiquimod therapy and PDT are needed.

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Section: Topical Imiquimod Therapymentioning

confidence: 99%

Nonsurgical Treatment Options for Basal Cell Carcinoma

Lien

Sondak

2011

Journal of Skin Cancer

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“…In the context of actinic field cancerization, this has also been referred to as the visualization of ‘subclinical lesions’. Similarly, some studies reported a cosmetic improvement of areas with actinic photodamage following treatment with IMIQ, suggesting an overall regenerative effect of this immunomodulatory treatment [16,17]. …”

Section: Introductionmentioning

confidence: 99%

Reflectance Confocal Microscopy for Noninvasive Monitoring of Therapy and Detection of Subclinical Actinic Keratoses

et al. 2009

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Background: Actinic keratoses (AK) represent cutaneous carcinoma in situ and have previously been evaluated by reflectance confocal microscopy (RCM). Treatment of AK with imiquimod (IMIQ) 5% cream has been shown to ‘highlight’ subclinical lesions. Objective: The aim of this study was to test the applicability of RCM for noninvasive monitoring of actinic field cancerization and detection of subclinical AK. Subjects and Methods: AK and surrounding skin sites with no apparent AK of 11 volunteers were selected for imaging and subsequently classified as ‘clinical’ and ‘subclinical’ AK. IMIQ was used 3 times weekly for 4 weeks. Results: RCM was able to detect morphologic features of AK in both clinical and subclinical AK; features were more pronounced in clinical lesions. The immunomodulatory response induced by IMIQ was visualized by RCM. Conclusion: Our findings indicate that RCM allows noninvasive monitoring of treatment response in vivo and permits early detection of subclinical AK, thus substantiating the incentive for therapy.

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“…One manifestation of photoaging is the appearance of skin wrinkles. UV light induced skin damage that it is mediated by signal transduction pathways …”

Section: Discussionmentioning

confidence: 99%

“…Persistent exposure to ultraviolet (UV) light leads to facial skin photodamage, which is characterized by wrinkles, dyspigmentation, and roughness . Although many physicians consider photoaging to be a cosmetic problem, it may serve as the background for the development of premalignant and malignant cutaneous conditions . Topical agents used in the treatment of photoaged skin include vitamin A derivatives such as tretinoin, tazarotene, and adapalene .…”

Section: Introductionmentioning

confidence: 99%

The effectiveness of imiquimod 5% cream as an anti‐wrinkle treatment: A pilot study

Altalhab

2019

J of Cosmetic Dermatology

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Summary Background Imiquimod 5% cream is currently approved to treat several dermatologic conditions including actinic keratoses (AK), superficial basal cell carcinoma (sBCC), and genital warts. However, there are numerous studies published on the alternative off‐label uses of imiquimod cream. Photoaging of facial skin is an important use for topical skin treatments, yet few studies have evaluated the effect of imiquimod cream for this dermatological condition. Methods This was a prospective, noncomparative pilot study. We included 15 healthy subjects; out of them, 11 subjects completed the study. The subjects were instructed to apply imiquimod 5% cream to the periorbital area on three nonconsecutive days per week for eight consecutive weeks. Photographs were obtained at baseline and after 8 weeks of treatment. Improvement in overall periorbital skin appearance was assessed by an independent investigator who compared the baseline and post‐treatment clinical photographs. In addition, post‐treatment self‐assessment was completed by the subjects using a 5‐point Likert scale. Results Eleven of the 15 subjects completed the 8‐week regimen. Eight participants (72.7%) noticed at least a fair improvement in periorbital skin changes based on the self‐assessed 5‐point Likert scale. Quartile score was also assessed by the investigator which indicated that seven subjects (63.6%) had at least 26% improvement. Based on Fitzpatrick wrinkle‐scoring system, there was a significant reduction in the subjects' wrinkle severity following treatment (6.8 [mean] ± 1.7 [SD] vs 4.6 ± 2.5 [P < 0.005]). Conclusions Imiquimod 5% cream may be a safe alternative anti‐aging treatment. Larger scale studies are needed to confirm these results.

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Imiquimod as an antiaging agent

Cited by 27 publications

References 9 publications

Nonsurgical Treatment Options for Basal Cell Carcinoma

Nonsurgical Treatment Options for Basal Cell Carcinoma

Reflectance Confocal Microscopy for Noninvasive Monitoring of Therapy and Detection of Subclinical Actinic Keratoses

The effectiveness of imiquimod 5% cream as an anti‐wrinkle treatment: A pilot study

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