Hanadie Yousef, Michael J. Conboy, Hikaru Mamiya, Matthew Zeiderman, Christina Schlesinger, David V. Schaffer, Irina M. Conboy
Abstract:Adult stem cells grow poorly in vitro compared to embryonic stem cells, and in vivo stem cell maintenance and proliferation by tissue niches progressively deteriorates with age. We previously reported that factors produced by human embryonic stem cells (hESCs) support a robust regenerative capacity for adult and old mouse muscle stem/progenitor cells. Here we extend these findings to human muscle progenitors and investigate underlying molecular mechanisms. Our results demonstrate that hESC-conditioned medium e…
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