Mechanisms of Action for Somatotropin in Growth

Boyd, R. D.; Bauman, Dale E.

doi:10.1007/978-1-4684-8872-2_12

Cited by 74 publications

(51 citation statements)

References 153 publications

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“…Effects of GH on growth are observed in several tissues, including bone, muscle and adipose tissue. These effects result from both direct action of GH on the partition of nutrients and cellular multiplication and IGF-1-mediated action stimulating cell proliferation and metabolic processes associated to protein deposition (Boyd and Bauman, 1989). IGF-1 stimulates the protein metabolism and is important for the function of some organs, being considered a factor of cellular proliferation and differentiation.…”

Section: Introductionmentioning

confidence: 99%

Association of GH and IGF-1 polymorphisms with growth traits in a synthetic beef cattle breed

et al. 2005

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The Canchim beef cattle (5/8 Charolais + 3/8 Zebu) has been selected for meat production in Brazil since late 1950. In the present work the effects of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) polymorphisms were investigated in 688 animals born between 1998 and 2000. These animals belonged to two genetic groups, i.e., traditional and new lineages. Genotype effects on expected breeding values for birth weight (BW), weaning weight (WW) and yearling weight (YW) were investigated by the least square method. Significant effects were found for GH genotype on YW (p ≤ 0.05), with positive effects associated with the LV (leucine/valine) genotype. For IGF-1 genotypes, significant effects were found on BW (p ≤ 0.01) and YW (p ≤ 0.01). Average substitution effects for IGF-1 alleles estimated by regression analysis suggested a positive effect of the IGF-1 225 bp allele on BW and of the 229 bp allele on YW.

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Section: Introductionmentioning

confidence: 99%

Association of GH and IGF-1 polymorphisms with growth traits in a synthetic beef cattle breed

et al. 2005

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“…GH has been reported to decrease lipogenesis and/or carcass fat deposition in vivo (reviewed in ref. 8) and to antagonize the development of adipocytes in cell culture (9,10). Thus, the present study was conducted to determine the influence of GH, alone and in combination with T 4 , on fetal adipose .…”

Section: Introductionmentioning

confidence: 99%

Endocrine Regulation of Fetal Adipose Tissue Metabolism in the Pig: Interaction of Porcine Growth Hormone and Thyroxine

Hausman

Martin

1999

Obesity Research

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HAUSMAN, D.B., GJ. HAUSMAN, AND RJ. MARTIN. Endocrine regulation of fetal adipose tissue metabolism in the pig: interaction of porcine growth hormone and thyroxine. Obes Res. 1999;7:76-82. Objective: This study tested the hypothesis that combined treatment of thyroxine (T 4) and growth hormone (GH) could normalize cellular and metabolic aspects of adipose tissue development of hypophysectomized fetal pigs. Research Methods and Procedures:On day 70 of gestation, pig fetuses were hypophysectomized by microcauterization or remained intact. Hypophysectomized fetuses remained untreated or were treated from day 90 to day 105 of gestation with T 4, GH, or a combination of both hormones. Results: Body weights were unaffected by hypophysectomy or hormone treatment. De novo lipogenesis in subcutaneous adipose tissue was increased 10-fold by hypophysectomy, consistent with our previous results. This increase was abolished by GH treatment in the hypophysectomized fetuses. In contrast, T 4 treatment of the hypophysectomized fetuses resulted in a 12-fold further increase in adipose tissue lipogenesis, an effect that was negated by concomitant administration of GH. Lipolytic response to isoproterenol was decreased by hypophysectomy, unaffected by GH treatment, and restored to intact values by T4 or by T4+GH treatment in the hypophysectomized fetuses. Discussion: In contrast to T 4 , GH does not influence serum insulin-like growth factor-lor adipose tissue lipolysis, but decreases lipogenesis in the fetal pig. However, replacing both T 4 and GH normalized hypophysectomized fetuses to a greater extent than either GH or T 4 alone. Thus, any

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“…O GH exerce grande impacto sobre a síntese de proteína corporal (Early et al, 1990); estudos têm evidenciado que o tratamento de animais domésticos com somatotropina exógena resulta em marcante crescimento do tecido muscular esquelético e redução na deposição de tecido adiposo (Boyd & Bauman, 1991).…”

Section: Introductionunclassified

Caracterização das fibras musculares do músculo Semitendinosus de bezerros mestiços Angus-Nelore recebendo somatotropina bovina recombinante (rbST) até a desmama

et al. 2005

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RESUMO -Objetivando-se estudar o efeito da somatotropina bovina recombinante (rbST) sobre a freqüência de distribuição e o diâmetro das fibras musculares do músculo Semitendinosus, 36 bezerros mestiços ½Angus-Nelore, com idade inicial de 63 ± 17 dias e pesando 76,8 ± 14,7 kg, criados em pastagem de Brachiaria decumbens e suplementados em creep feeding, foram submetidos a dois tratamentos até a desmama (217 dias): 18 bezerros receberam 1,4 mg/kg de rbST (Boostin ® ) a cada 14 dias e 18 receberam solução salina (controle). As amostras de músculo foram coletadas aos 117 (biópsia) e aos 217 dias de idade, quando foram abatidos cinco animais por tratamento. Os animais suplementados apresentaram maior diâmetro para as fibras do tipo glicolítica de contração rápida (FG) aos 117 dias e tendência de aumento aos 217 dias e não diferiram em relação ao grupo controle quanto ao diâmetro das fibras oxidativas-glicolíticas de contração rápida (FOG) e oxidativas de contração lenta (SO) e à frequência de FG, FOG e SO aos 117 e 217 dias de idade. Independentemente da aplicação de rbST, houve significativo aumento do diâmetro das fibras SO e FOG, tendência de aumento de diâmetro das fibras FG, maior frequência de SO e redução da frequência de FG entre 117 e 217 dias de idade. A utilização de somatotropina exógena possibilitou maior hipertrofia das fibras musculares brancas de contração rápida em bezerros suplementados em creep feeding durante a fase de cria, sem interferir na frequência de distribuição dos tipos de fibras no músculo Semitendinosus. Palavras-chave: creep feeding, crescimento, superprecoce Characterization of Semitendinosus Muscle Fibers in Pre-Weaning Angus-Nellore Crossbred Calves Receiving Recombinant Bovine Somatotropin (rbST)ABSTRACT -The objective of this experiment was to study the effect of the recombinant bovine somatotropin (rbST) on the percentage distribution and diameter of semitendinosus muscle fibers. Thirty-six ½ Angus-Nellore crossbred bull calves, 63 ± 17 days old and weighting 76.8 ± 14.7 kg, raised in Brachiaria decumbens pastures and creep fed, were assigned to one of two treatments until weaning (217 days): eighteen calves received 1.4 mg/kg of rbST (Boostin ® ) every 14 days and eighteen control calves received saline solution. Muscle samples were taken at 117 trough biopsy and at 217 days old when five animals from each treatment were slaughtered. The rbST-treated calves had greater fast-twich-glycolytic (FG) fiber diameter than control ones at 117 days and tended to have great diameter at 217 days. No differences in fast-twich-glycolytic-oxidative (FOG) and slow-twich-oxidative (SO) diameter and FG, FOG and SO percentage distribution were observed at 117 and 217 days. Despite the rbST treatment, there was a significant enlarge in SO and FOG fibers diameter, a tendency for increase in FG fibers diameter, an increase in SO and reduction in FG percentage distribution from 117 to 217 days. The somatotropin administration caused a greater hypertrophy of the white fast twitch muscle fibers in cree...

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Mechanisms of Action for Somatotropin in Growth

Cited by 74 publications

References 153 publications

Association of GH and IGF-1 polymorphisms with growth traits in a synthetic beef cattle breed

Association of GH and IGF-1 polymorphisms with growth traits in a synthetic beef cattle breed

Endocrine Regulation of Fetal Adipose Tissue Metabolism in the Pig: Interaction of Porcine Growth Hormone and Thyroxine

Caracterização das fibras musculares do músculo Semitendinosus de bezerros mestiços Angus-Nelore recebendo somatotropina bovina recombinante (rbST) até a desmama

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