Association of GH and IGF-1 polymorphisms with growth traits in a synthetic beef cattle breed

Abstract

The Canchim beef cattle (5/8 Charolais + 3/8 Zebu) has been selected for meat production in Brazil since late 1950. In the present work the effects of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) polymorphisms were investigated in 688 animals born between 1998 and 2000. These animals belonged to two genetic groups, i.e., traditional and new lineages. Genotype effects on expected breeding values for birth weight (BW), weaning weight (WW) and yearling weight (YW) were investigated by the least square method. Significant effects were found for GH genotype on YW (p ≤ 0.05), with positive effects associated with the LV (leucine/valine) genotype. For IGF-1 genotypes, significant effects were found on BW (p ≤ 0.01) and YW (p ≤ 0.01). Average substitution effects for IGF-1 alleles estimated by regression analysis suggested a positive effect of the IGF-1 225 bp allele on BW and of the 229 bp allele on YW.

Growth Hormone Gene Polymorphism and Its Association with Partial Cumulative Milk Yields of Holstein Friesian Dairy Cattle

“…Visualization of the genotypes of the GH|AluI gene was presented in Figure 3. These results were in line with the study by Pereira et al (2005) by obtaining two genotypes (LL and LV) in Brazilian Canchim cattle. Another study by Curi et al (2006) did not find the VV genotype in Brazilian Zebu cattle and its crosses.…”

IGF-I gene polymorphism, but not its blood concentration, is associated with milk fat and protein in Holstein dairy cows

“…In Angus cattle, these primers produced a frequency of 0.64 for the A allele and 0.36 for the B allele (Ge et al, 2001). Synthetic Canchim breed (5/8 Charolais + 3/8 Zebu) and cows from Simmental and Angus sires and Nellore dams, have low frequencies of the A allele (0.35, 0.2 and 0.32, respectively) compared to the B allele (Curi et al, 2005;Pereira et al, 2005). In our study, similar frequencies were obtained for the two alleles (B allele = 0.542; A allele = 0.463).…”

“…The role of IGF-I and its binding proteins has been reviewed (Sara and Hall, 1990;Jones and Clemmons, 1995); IGF-I mediates cell proliferation and is essential for normal development of the mammary gland during puberty and pregnancy (Marshman and Streuli, 2002). Most studies of beef cattle have revealed an association between gene polymorphism and body condition scoring and weight, particularly in early life stages (Ge et al, 2001;Spicer et al, 2002;Curi et al, 2005;Pereira et al, 2005). Significant relationship between milk production and gene character, and a different pattern for corrected 305-day milk productions implies an important physiological role of this somatomedin in other parts of the body.…”

Candidate genes for production traits in Nelore beef cattle

“…According to Islam et al (2009), several studies have identified a quantitative trait locus (QTL) associated with carcass traits in the vicinity of IGF1 in beef cattle. Several studies have associated polymorphisms in IGF1 with growth traits in beef cattle as well (Pereira et al, 2005;Andrade et al, 2008). Islam et al (2009) have associated an SNP in the promoter region of IGF1, the same region in which the microsatellite used in this study resides with fat deposition and other carcass traits in crossbred Angus and Charolais beef cattle.…”

“…The mean allele substitution effect was 6.9 kg, with the 229 allele associated with reduced YW in this Nelore population. Pereira et al (2005) have investigated the effect of the IGF1 microsatellite studied here on growth traits in a Canchim beef cattle population. The authors found a positive average substitution effect of the IGF1 225-bp allele on birth weight and of the 229-bp allele on YW.…”