Mechanisms linking hyperglycemia in pregnancy to the offspring cardiovascular system dysfunction

Xiao, Zemeng; Wang, Yifang; Thai, Phung N.; Li, Xuxia; Lu, Xiyuan; Pu, Jun

doi:10.37175/stemedicine.v2i7.91

Cited by 9 publications

(7 citation statements)

References 82 publications

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“…GDM is the most common pregnant disorder that endangers both the pregnant women and their offspring without timely and proper treatment, such as the increased risk of T2DM. 21 , 22 Therefore, proper management of GDM is important to minimize maternal and neonatal complications. Current conventional treatments for GDM include a special diet, daily exercise, and monitoring blood glucose.…”

Section: Discussionmentioning

confidence: 99%

Vitamin E Supplement Protects Against Gestational Diabetes Mellitus in Mice Through nuclear factor-erythroid factor 2-related factor 2/heme oxygenase-1 Signaling Pathway

Lin¹,

Zhang²

2023

DMSO

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Background Gestational diabetes mellitus (GDM) is the most common pregnant disorder worldwide. In this study, we aimed to explore whether vitamin E (VE) treatment alone could protect against GDM in a mouse model. Methods 6-week-old C57BL/6J female mice were fed on high-fat diet for two weeks and continued with high-fat diet after pregnancy to induce GDM. The pregnant mice were orally administrated with 2.5, 25 or 250 mg/kg VE twice per day during pregnancy together with high-fat diet. Oral glucose tolerance test, insulin amounts, oxidative stress and inflammation were then measured. Results Only 250 mg/kg VE could improve glucose tolerance and insulin level in pregnant mice. VE (250 mg/kg) effectively inhibited GDM-induced hyperlipidemia, and secretion of inflammatory cytokines such as tumor necrosis factor-α and interleukin-6. VE also significantly ameliorated maternal oxidative stress at the late stage of pregnancy, and also improved reproductive outcomes, including increasing the litter size and birth weight in GDM mice. Moreover, VE also activated GDM-reduced nuclear factor-erythroid factor 2-related factor 2 (Nrf2) / heme oxygenase-1 signaling pathway in the maternal liver tissues of GDM mice. Conclusion Our data clearly demonstrated that 250 mg/kg VE twice a day during pregnancy could significantly ameliorate the symptoms of GDM by alleviating oxidative stress, inflammation, hyperglycemia, and hyperlipidemia through Nrf2/HO-1 signaling pathway in GDM mice. Thus, additional VE supplement might be beneficial to GDM.

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Section: Discussionmentioning

confidence: 99%

Vitamin E Supplement Protects Against Gestational Diabetes Mellitus in Mice Through nuclear factor-erythroid factor 2-related factor 2/heme oxygenase-1 Signaling Pathway

Lin¹,

Zhang²

2023

DMSO

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“…Oxidative stress has been implicated in the development of hypertension [33, 34]. Hypertension is associated with vascular alternation including endothelial dysfunction, leading to a reduction in NO production [33, 35].…”

Section: Discussionmentioning

confidence: 99%

Naringenin Protects against Hypertension by Regulating Lipid Disorder and Oxidative Stress in a Rat Model

Liu

Zhao

Che

et al. 2022

Kidney Blood Press Res

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Background: Naringenin, a natural resource-derived flavanone, exhibits a plethora of pharmacological properties. The present study aimed to investigate the effects of Naringenin on obesity-associated hypertension and its underlying mechanism. Methods: Obesity-associated hypertension rat model was established with a high-fat diet (HFD) and was administrated with Naringenin (25, 50, 100 mg/kg). Body and fat weight were recorded and blood pressure was measured. Serum lipid parameters (cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides), oxidative stress biomarkers (malondialdehyde (MDA), superoxide dismutase (SOD), nitrite oxide (NO), and glutathione (GSH)), and adipocytokines (leptin and adiponectin) were determined. The expressions of signal transducer and activator of transcription (STAT) 3 were determined by using Western blotting. Results: Treatment with Naringenin (100 mg/kg) reduced body and fat weight in HFD-induced rats. Besides, treatment with Naringenin (50 and 100 mg/kg) reduced blood pressure and regulated lipid parameters by decreasing cholesterol, triglycerides, and LDL and increasing HDL. Treatment with Naringenin (50 and 100 mg/kg) reduced serum MDA and NO, whereas increased serum SOD and GSH. Furthermore, Treatment with Naringenin (50 and 100 mg/kg) regulated adipocytokines and decreased the phosphorylation of STAT3. Conclusion: Naringenin ameliorates obesity-associated hypertension by regulating lipid disorder and oxidative stress.

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“…The incidence of diabetes is increasing especially among the elderly population, reaching 12%–25% in those over 65 years old, with a trend toward younger ages as well. T2DM is a chronic metabolic disorder characterized by insulin resistance and sustained hyperglycemia (Xiao et al., 2021), which are correlated with multiple macrovascular and microvascular complications. These complications, together with chronic inflammation, are important risk factors for accelerated cognitive impairment.…”

Section: Introductionmentioning

confidence: 99%

The whole‐brain voxel‐based morphometry study in early stage of T2DM patients

Liu

2022

Brain and Behavior

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Aim: This study aimed to investigate the alterations in whole-brain gray matter density in early stage type 2 diabetes mellitus (T2DM) patients with cognitive impairment using magnetic resonance imaging.Methods: Thirty-six cases of early stage T2DM patients with cognitive impairment (T2DM-CI), 34 cases of early stage T2DM patients without cognitive impairment (T2DM) and 30 cases of healthy controls (HC) were enrolled. Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) scores were used to identify the cognitive impairment. The whole-brain gray matter density was analyzed using 3D-T1 BRAVO imaging, using the voxel-based morphometry method on T1 structure imaging of two groups. Results:The correlation analysis of total gray matter density with MMSE and MoCA scores in the T2DM-CI group was performed. There were no significant differences in MMSE and MoCA scores between the HC and T2DM groups. However, the MMSE and MoCA scores in the T2DM-CI group were significantly reduced compared with the T2DM group. There were no significant differences in age, gender, education, body mass index (BMI) or blood pressure among the three groups. Voxel-based morphometry (VBM) results showed that the density of left triangle part of inferior frontal gyrus, orbital part of inferior frontal gyrus and opercular part of inferior frontal gyrus and left insula in the T2DM-CI group decreased compared with the T2DM group. Correlation analysis results showed that there was a significant positive correlation between total gray matter density and scores of MMSE and MoCA scores in the T2DM-CI group. Conclusion:In conclusion, total gray matter density is positively correlated with the scores of MMSE and MoCA in T2DM patients, which may be an early sign of cognitive impairment in patients with T2DM.

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Mechanisms linking hyperglycemia in pregnancy to the offspring cardiovascular system dysfunction

Cited by 9 publications

References 82 publications

Vitamin E Supplement Protects Against Gestational Diabetes Mellitus in Mice Through nuclear factor-erythroid factor 2-related factor 2/heme oxygenase-1 Signaling Pathway

Vitamin E Supplement Protects Against Gestational Diabetes Mellitus in Mice Through nuclear factor-erythroid factor 2-related factor 2/heme oxygenase-1 Signaling Pathway

Naringenin Protects against Hypertension by Regulating Lipid Disorder and Oxidative Stress in a Rat Model

The whole‐brain voxel‐based morphometry study in early stage of T2DM patients

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