Vitamin E Supplement Protects Against Gestational Diabetes Mellitus in Mice Through nuclear factor-erythroid factor 2-related factor 2/heme oxygenase-1 Signaling Pathway

NRF2 deficiency leads to inadequate beta cell adaptation during pregnancy and gestational diabetes

“…Notably, prevention of GDM using broad spectrum antioxidants is still controversial. While treatment with N-Acetyl- l -cysteine (NAC), vitamin E and vitamin C have been reported to ameliorate diabetes in GDM and T2D mouse models [ [91] , [92] , [93] , [94] , [95] ], clinical trials in women with GDM are still lacking and the administration of NAC to T2D patients did not improve their glycemia [ 96 ]. It might be that the administration of NAC blocked ROS-dependent activation of endogenous NRF2 signaling.…”

NRF2 deficiency leads to inadequate beta cell adaptation during pregnancy and gestational diabetes

“…Notably, prevention of GDM using broad spectrum antioxidants is still controversial. While treatment with N-Acetyl- l -cysteine (NAC), vitamin E and vitamin C have been reported to ameliorate diabetes in GDM and T2D mouse models [ [91] , [92] , [93] , [94] , [95] ], clinical trials in women with GDM are still lacking and the administration of NAC to T2D patients did not improve their glycemia [ 96 ]. It might be that the administration of NAC blocked ROS-dependent activation of endogenous NRF2 signaling.…”

Ulva lactuca extracellular vesicles protect against high-fat diet-induced intestinal damage via Nrf2/Keap1/HO-1 activation

“…8 However, sustained HFD exposure impairs this pathway through Keap1-mediated Nrf2 degradation, reducing antioxidant capacity and aggravating epithelial injury. 9 Thus, HFD compromises intestinal integrity by disrupting TJ proteins and inhibiting the Nrf2/Keap1/HO-1 pathway; however, the precise involvement of Nrf2 suppression in mucosal injury remains unclear.…”

NRF2 deficiency leads to inadequate beta cell adaptation during pregnancy and gestational diabetes

“…Notably, prevention of GDM using broad spectrum antioxidants is still controversial. While treatment with N-Acetyl- l -cysteine (NAC), vitamin E and vitamin C have been reported to ameliorate diabetes in GDM and T2D mouse models [ [91] , [92] , [93] , [94] , [95] ], clinical trials in women with GDM are still lacking and the administration of NAC to T2D patients did not improve their glycemia [ 96 ]. It might be that the administration of NAC blocked ROS-dependent activation of endogenous NRF2 signaling.…”

Ulva lactuca extracellular vesicles protect against high-fat diet-induced intestinal damage via Nrf2/Keap1/HO-1 activation

“…8 However, sustained HFD exposure impairs this pathway through Keap1-mediated Nrf2 degradation, reducing antioxidant capacity and aggravating epithelial injury. 9 Thus, HFD compromises intestinal integrity by disrupting TJ proteins and inhibiting the Nrf2/Keap1/HO-1 pathway; however, the precise involvement of Nrf2 suppression in mucosal injury remains unclear.…”

NRF2 deficiency leads to inadequate beta cell adaptation during pregnancy and gestational diabetes

“…Notably, prevention of GDM using broad spectrum antioxidants is still controversial. While treatment with N-Acetyl- l -cysteine (NAC), vitamin E and vitamin C have been reported to ameliorate diabetes in GDM and T2D mouse models [ [91] , [92] , [93] , [94] , [95] ], clinical trials in women with GDM are still lacking and the administration of NAC to T2D patients did not improve their glycemia [ 96 ]. It might be that the administration of NAC blocked ROS-dependent activation of endogenous NRF2 signaling.…”

Ulva lactuca extracellular vesicles protect against high-fat diet-induced intestinal damage via Nrf2/Keap1/HO-1 activation

“…8 However, sustained HFD exposure impairs this pathway through Keap1-mediated Nrf2 degradation, reducing antioxidant capacity and aggravating epithelial injury. 9 Thus, HFD compromises intestinal integrity by disrupting TJ proteins and inhibiting the Nrf2/Keap1/HO-1 pathway; however, the precise involvement of Nrf2 suppression in mucosal injury remains unclear.…”