Mechanisms involved in the antinociception caused by agmatine in mice

Santos, Adair R.S.; Gadotti, Vinícius M.; Oliveira, Gerson L.; Tibola, Daiane; Paszcuk, Ana Flávia; Neto, Amaro; Spindola, Humberto M.; Souza, Márcia María de; Rodrigues, Ana Lúcia S.; Calixto, João B.

doi:10.1016/j.neuropharm.2005.01.012

Cited by 120 publications

(73 citation statements)

References 75 publications

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“…39) Baclofen, a derivative of GABA, is a potent GABA B receptor agonist, which is clinically used for the treatment of spasticity, many types of neuropathic pain, but also induces analgesia in certain animal models of pain. [40][41][42][43] In this study and others realized in our laboratories 11,12,44) the results confirm that baclofen and muscimol markedly antagonizes acetic acidinduced nociception. In contrast, GABA A or the GABA B antagonists bicuculline or phaclofen did not reversed the antinociceptive effect of AMB, demonstrating that the antinociceptive effect of this compound does not involve the action of the GABAergic pathways.…”

Section: )supporting

confidence: 80%

Assessment of Mechanisms Involved in Antinociception Caused by Myrsinoic Acid B

Hess

Padoani

Scorteganha

et al. 2010

Biological & Pharmaceutical Bulletin

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Considerable efforts have recently been made to discover new analgesic and antiinflammatory agents with increased efficacy and improved side effect profiles. In this context, the compounds obtained from medicinal plants have been extensively studied.1,2) Prenylated aromatic compounds isolated from plant sources are common in the literature, including some that are diprenylated benzoic acids. This class of compounds is present in Rapanea genus and has been demonstrated to have anti-inflammatory activity, 3) then the compound 5-carboxy-2,3-dihydro-2-(1Ј,5Ј-dimethyl-1Ј-hydroxy-4Ј-hexenyl)-7-(3Љ-methyl-2Љ-butenyl) benzofuran, also known as myrsinoic acid B (AMB) (Fig. 1) was chosen in this study. It was first isolated as methyl ester from Rapanea umbellatta 4) and was also reported in R. lancifolia, R. guaianensis, 5) R. Myricoides 6) and R. Seguinii.3) So far only antiinflammatory and methioninase inhibitory activities have been reported for this compound.3,7) We have previously verified that AMB, isolated from the bark of CHCl 3 extract of Rapanea ferruginea, exhibits significant and potent antinociceptive action when evaluated in some pharmacological models of pain in mice. 8) In this study, we investigated some of the possible mechanisms, underlying the antinociceptive action of AMB. Extraction and Isolation of AMB Bark of Rapanea ferruginea (600 g) was dried at 40°C for 2 d, powdered and successively extracted by maceration with CHCl 3 for 7 d at room temperature. The extract was concentrated under reduced pressure, to yield residues (70.2 g). The CHCl 3 extract (60 g) was chromatographed in a silica-gel column with hexane/ ethyl acetate. The fraction eluted with 40% ethyl-acetate in hexane to give impure AMB. This fraction (8.5 g) was rechromatographed in a silica-gel column and with 30% ethyl-acetate in hexane give pure AMB (4.3 g). MATERIALS AND METHODS Plant Material

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Section: )supporting

confidence: 80%

Assessment of Mechanisms Involved in Antinociception Caused by Myrsinoic Acid B

Hess

Padoani

Scorteganha

et al. 2010

Biological & Pharmaceutical Bulletin

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“…16) It has been demonstrated that intraplantar injection of formalin in rodents produces significant increases in spinal levels of different mediators, such as excitatory amino acids, PGE 2 , nitric oxide and tachykinin, kinins among other peptides. 17,18) Furthermore, systemic spinal and supraspinal administration of tachkinin receptor antagonists, nitric oxide synthase (NOS) inhibitors, N-methyl-D-aspartate (NMDA) receptor antagonists, opioids, a 2 adrenoceptor agonist, and NSAIDS, were all found to be effective in antagonizing formalin-induced nociception. 17,19,20) Intraplantary injection of formalin produces distinct biphasic pain, called early and late phases.…”

Section: Resultsmentioning

confidence: 99%

Further Antinociceptive Properties of Extracts and Phenolic Compounds from Plinia glomerata (Myrtaceae) Leaves

Fischer

Santos

Serafin

et al. 2008

Biological & Pharmaceutical Bulletin

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“…The time, in seconds, that each mouse spent licking its right hind paw was used as the nociception indicator [38,39].…”

Section: Involvement Of the Opioid Systemmentioning

confidence: 99%

Involvement of Opioid System, TRPM8, and ASIC Receptors in Antinociceptive Effect of <em>Arrabidaea Brachypoda </em>(DC) Bureau

Rodrigues¹,

Rocha²,

Périco³

et al. 2017

Preprint

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Arrabidaea brachypoda (DC) Bureau is a medicinal plant found in Brazil. Known as "cipó-una", it is popularly used as a natural therapeutic agent against pain and inflammation. This study evaluated the chemical composition and antinociceptive activity of the dichloromethane fraction from the roots of A. brachypoda (DEAB) and its mechanism of action. The chemical composition was characterized by high-performance liquid chromatography, and this fraction is composed only of dimeric flavonoids. The antinociceptive effect was evaluated in formalin and hot plate tests after oral administration (10-100 mg/kg) in male Swiss mice. We also investigated the involvement of TRPV1 (transient receptor potential vanilloid 1), TRPA1 (transient receptor potential ankyrin 1), TRPM8 (transient receptor potential melastatin 8), and ASIC (acid-sensing ion channel), as well as the opioidergic, glutamatergic, and supraspinal pathways. Moreover, the nociceptive response was reduced (30 mg/kg) in the early and late phase of the formalin test. DEAB activity appears to involve the opioid system, TRPM8, and ASIC receptors, clearly showing that the DEAB alleviates acute pain in mice and suggesting the involvement of the TRPM8 and ASIC receptors and the opioid system in acute pain relief.

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Mechanisms involved in the antinociception caused by agmatine in mice

Cited by 120 publications

References 75 publications

Assessment of Mechanisms Involved in Antinociception Caused by Myrsinoic Acid B

Assessment of Mechanisms Involved in Antinociception Caused by Myrsinoic Acid B

Further Antinociceptive Properties of Extracts and Phenolic Compounds from Plinia glomerata (Myrtaceae) Leaves

Involvement of Opioid System, TRPM8, and ASIC Receptors in Antinociceptive Effect of <em>Arrabidaea Brachypoda </em>(DC) Bureau

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