Further Antinociceptive Properties of Extracts and Phenolic Compounds from Plinia glomerata (Myrtaceae) Leaves

Fischer, Luiz G. O.; Santos, Diogo Adolfo dos; Serafin, Cláudia; Malheiros, Ângela; Monachè, Franco Delle; Monache, Giuliano Delle; Filho, Valdir Cechinel; Souza, Márcia María de

doi:10.1248/bpb.31.235

Cited by 40 publications

(22 citation statements)

References 17 publications

(17 reference statements)

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“…Past studies have postulated that the acetic acid acts indirectly by inducing the release of endogenous mediators which stimulate the nociceptive neurons sensitive to nonsteroidal anti-inflammatory drugs (NSAIDs) and opioids (Fischer et al, 2008). Although abdominal writhing induced by acetic acid represents a peripheral nociception model (Wei et al, 1986) and is normally used for screening synthetic and natural compounds, this is not a specific model, since several compounds, including opioid analgesics (Gomes et al, 2005) tricyclic antidepressants (Carter & Sullivan, 2002) and antihistaminic compounds (Koster et al, 1959) inhibit acetic acid induced writhing.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical screening, antinociceptive and anti-inflammatory activities of Chrysopogon zizanioides essential oil

Lima¹,

Quintans‐Júnior²,

Thomazzi³

et al. 2012

Rev. bras. farmacogn.

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Abstract:Chrysopogon zizanioides (L.) Roberty, Poaceae, is a plant widely used in northeast Brazil in folk medicine for the treatment of various pathological conditions, including infl ammatory pain. The present study evaluated the antinociceptive and antiinfl ammatory effects of C. zizanioides essential oil (EO) in rodents. EO was further characterized by GC/MS. The major components of EO were identifi ed as khusimol (19.57%), E-isovalencenol (13.24%), α-vetivone (5.25%), β-vetivone (4.87%) and hydroxy-valencene (4.64%). Following intraperitoneal injection (i.p.), EO at 50 and 100 mg/kg signifi cantly reduced the number of writhes (51.9 and 64.9%, respectively) and the number of paw licks during phase 2 (56.7 and 86.2%, respectively) of a formalin model when compared to control group animals. However, EO-treated mice were ineffective at all doses in hot-plate and rota-rod tests. The EO inhibited the carrageenan-induced leukocyte migration to the peritoneal cavity in a dose-dependent manner (34.7, 35.4, and 62.5% at doses of 25, 50 and 100 mg/kg, respectively). In the paw edema test, the EO (100 mg/kg) inhibited all three phases of the edema equally well, suggesting that the EO has a non-selective inhibitory effect on the release or actions of these mediators. Our results suggest possible antinociceptive and antiinfl ammatory effects of the EO.

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Section: Discussionmentioning

confidence: 99%

Phytochemical screening, antinociceptive and anti-inflammatory activities of Chrysopogon zizanioides essential oil

Lima¹,

Quintans‐Júnior²,

Thomazzi³

et al. 2012

Rev. bras. farmacogn.

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“…O ácido acético induz contorções abdominais por meio da liberação de mediadores endógenos, que estimulam os neurônios nociceptivos. E a resposta nociceptiva induzida pelo ácido acético é sensível tanto aos anti-inflamatórios esteroidais e não esteroidais quanto aos analgésicos opióides (DUTRA et al, 2006;FISCHER et al, 2008). A dipirona é um dos principais analgésicos utilizados pela terapêutica brasileira.…”

Section: Resultsunclassified

Efeito antinociceptivo da própolis oriunda de duas vegetações distintas

Batista

Trindade

Batista

2015

Semin. Cienc. Biol. Saude

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ResumoThe aim of this study was to evaluate the analgesic effect of propolis, comparing solutions prepared from propolis obtained from the apiary of the Centre for Agricultural Sciences (CCA) of the Federal University of Piauí, with the extract from the Apis Flora Laboratory. Forty eight mice were divided into six groups treated with hydroethanol solution (vehicle, 20mL/Kg, p.o.), dipyrone (positive control, 50mL/Kg, p.o.), propolis solution 10% (obtained from CCA and Apis Flora, 20mL/Kg, p.o.) and propolis 20% solution (obtained from CCA and Apis Flora, 20mL/Kg, p.o.). The nociceptive stimulus was induced by intraperitoneal (i.p.) administration of 0.6% acetic acid 20 minutes after administration of each treatment. The number of writhing was performed, for a period of 20 minutes, and the inhibition percentage of the painful sensation provided by each treatment were calculated. The results showed that the control group, treated with hydroethanol solution, was significantly different from all others, and those treated with propolis solution at 10% and 20% from, both sources do not differ significantly from each other and not the positive control, showing similar analgesic effect.Palavras-chave: Dor. Própolis. Antinocicepção.

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“…The hot plate test is a good model for studying central activity, being selectivity for drugs as opioid-derived analgesics. This assay is thought to involve the supraspinal reflex , produce an acute non-inflammatory nociception and moderate analgesic appear to have less or nothing effect in this kind of test (Zakaria et al, 2006a,b;Fischer et al, 2008). In this test, the ME affected mice latency time from the thermal stimulus, showing that ME antinociception may have the participation of central action.…”

Section: Discussionmentioning

confidence: 95%

“…The writhing induced by acetic acid in mice result from chemical-induced a peripheral acute inflammatory reaction (Zakaria et al, 2006a). The treatment with ME promoted a dose-related antinociceptive effect in this model, normally used for screening of synthetic and natural compounds to determinate the presence of central and/or peripheral antinociceptive activity, because it is sensitive to nonsteroidal anti-inflammatory drugs (NSAID) and opioids (Zakaria et al, 2006b;Fischer et al, 2008). Moreover, the nociception induced in writhing method has been associated with some prostanoids, like as PGE 2 , PGF 2α and PGI 2 (Deraedt et al, 1980) as well as lipoxygenase products (Ballou et al, 2000;Parveen et al, 2007), neurokinin A (Julia & Buéno, 1997) and CGRP (Friese et al, 1997), for example.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, naloxone also reversed antinociception produced of ME in both phases of the test. It has been demonstrated that intraplantar injection of formalin in rodents produces significant increases in spinal levels of different mediators, such as excitatory aminoacids, PGE 2 , nitric oxide and tachykinin, kinins, among other peptides (Fischer et al, 2008). The test produced a distinct biphasic nociceptive response generally regarded as the early (first) and late (second) phases.…”

Section: Discussionmentioning

confidence: 99%

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Anti-inflammatory and opioid-like activities in methanol extract of Mikania lindleyana, sucuriju

Vanderlinde¹,

Rocha²,

Malvar³

et al. 2012

Rev. bras. farmacogn.

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Mikania lindleyana DC., Asteraceae (sucuriju), grows in the Amazon region, where is frequently used to treat pain, inflammatory diseases and scarring. This study was carried out to investigate phytochemical profile accompanied by in vivo antinociceptive and anti-inflammatory screening of n-hexane (HE), dichloromethane (DME) and methanol (ME) extracts obtained from the aerial parts of the plant. The oral administration of ME (0.1, 0.3, 1 g/kg) caused a dose-related reduction (16.2, 42.1 e 70.2%) of acetic acid-induced abdominal writhing while HE and DME (1 g/kg, p.o.) were ineffective. In the hot plate test, ME (300 mg/kg, p.o.) increased the latency of heat stimulus between 30 and 120 min and inhibited the first (45%) and second (60%) phases of nociception in the formalin test. The antinociception induced by ME or positive control fentanyl (150 µg/kg, s.c.) in hot plate and formalin tests was prevented by naloxone (3 mg/kg, s.c.). When submitted to the carrageenan-induced peritonitis test, ME (0.5, 1.0, 2.0 g/kg, p.o.) impaired leukocyte migration into the peritoneal cavity by 46.8, 59.4 and 64.8% respectively, while positive control dexamethasone (2 mg/kg, s.c.), inhibited leukocyte migration by 71.1%. These results indicate that the antinociception obtained after oral administration of methanol extract of M. lindleyana involves anti-inflammatory mechanisms accompanied with opioid-like activity which could explain the use of the specie for pain and inflammatory diseases.

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Further Antinociceptive Properties of Extracts and Phenolic Compounds from Plinia glomerata (Myrtaceae) Leaves

Cited by 40 publications

References 17 publications

Phytochemical screening, antinociceptive and anti-inflammatory activities of Chrysopogon zizanioides essential oil

Phytochemical screening, antinociceptive and anti-inflammatory activities of Chrysopogon zizanioides essential oil

Efeito antinociceptivo da própolis oriunda de duas vegetações distintas

Anti-inflammatory and opioid-like activities in methanol extract of Mikania lindleyana, sucuriju

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