Mechanisms and performance measures in mastery-based incremental repeated acquisition: behavioral and pharmacological analyses

Bailey, James; Johnson, Joshua E.; Newland, M. Christopher

doi:10.1007/s00213-010-1801-3

Cited by 11 publications

(21 citation statements)

References 36 publications

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“…The IRA procedure has been described in detail previously [20]. The IRA procedure consisted of daily 60-min sessions in which a maximum of a six-link chain could be reached by backward chaining.…”

Section: Methodsmentioning

confidence: 99%

Effect size of memory deficits in mice with adult-onset P301L tau expression

Hunsberger

Rudy

Weitzner

et al. 2014

Behavioural Brain Research

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Transgenic mice expressing mutations in tau have yielded essential discoveries for Alzheimer’s disease. One of the most commonly used tau mouse models is the tet-off Tg(tauP301L)4510 model that expresses P301L human tau driven by the calcium-calmodulin kinase IIα (CaMKIIα) promoter system. Tau expression in this model is regulatable, allowing for suppression of mutant tau expression until adulthood and prevention of possible developmental alterations resulting from P301L tau expression during development. Here, we compared the effect and sample sizes needed for three learning and memory tasks in mice with adult-onset P301L tau expression. Our findings indicate that the Incremental Repeated Acquisition (IRA) and trace fear conditioning tasks, neither of which have previously been published with these mice, were highly sensitive to P301L tau expression, whereas the Morris water maze, the most commonly used task with this model, was the least sensitive. Memory deficits were observed at a time when tau pathology was subtle and prior to readily detectable neuronal loss. Thus, we provide essential information (effect and sample sizes needed) for establishing experimental designs at a time point when memory deficits are likely to go undetected if inadequate sample sizes are used. Our work also suggests the tet-off Tg4510 model provides a way to avoid mutant tau expression during the perinatal and early postnatal stages, thereby preventing possible developmental alterations unrelated to Alzheimer’s disease.

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Section: Methodsmentioning

confidence: 99%

Effect size of memory deficits in mice with adult-onset P301L tau expression

Hunsberger

Rudy

Weitzner

et al. 2014

Behavioural Brain Research

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“…Adolescent (PND 38) and adult (PND 73) mice responded on three distinct response levers under an IRA procedure in which a response chain incremented from a one to a maximum of a six-link chain using backward chaining (Bailey, et al, 2010). Unlike the SDR procedure, response levers inserted into the chamber at the start of session never retracted until the session terminated.…”

Section: Methodsmentioning

confidence: 99%

“…There is high correlation, r=0.53, between measures of IRA accuracy and IQ scores in human children (Paule et al, 1999) and improvement demonstrates a developmental time course (Baldwin et al, 2012). Specifically, the dependent measure progress quotient (PQ), directly related to the number of reinforcers earned at a given chain length, can vary over a dynamic range and serve as an independent, overall measure of performance (Bailey et al, 2010; Johnson et al, 2010). The IRA procedure has been used with a wide variety of species, including rats, mice, pigeons, and non-human primates (Cohn & Paule, 1995) and has garnered extensive use when evaluating acute drug effects and chronic exposure to environmental contaminants (Bailey et al, 2013; Paule & McMillan, 1984).…”

Section: Introductionmentioning

confidence: 99%

“…The IRA procedure has been used with a wide variety of species, including rats, mice, pigeons, and non-human primates (Cohn & Paule, 1995) and has garnered extensive use when evaluating acute drug effects and chronic exposure to environmental contaminants (Bailey et al, 2013; Paule & McMillan, 1984). A mastery-based approach allows task difficulty to adjust in real time according to the animal’s performance, an approach that has led to the production of very long response chains by mice (Bailey et al, 2010; Johnson, et al, 2010). The dynamic, within-session adjustment of difficulty allows for identification of influential factors within individual animals.…”

Section: Introductionmentioning

confidence: 99%

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Spatial discrimination reversal and incremental repeated acquisition in adolescent and adult BALB/c mice

Shen

Pope

Hutsell

et al. 2015

Behavioural Processes

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Adolescence is characterized by neural and behavior development that includes increases in novel experiences and impulsive choice. Experimental rodent models can characterize behavior phenotypes that typify adolescence. The present experiment was designed to characterize differences between adolescent (post-natal day (PND) 34 - 60) and adult (PND 70 - 96) BALB/c mice using a response-initiated spatial discrimination reversal (SDR) and incremental repeated acquisition of response chains (IRA) procedures. During SDR, adolescents omitted more trials and were slower to initiate trials than adults, but the age groups did not differ on accuracy and perseveration measures. During IRA, adolescents displayed poorer overall performance (measured by progress quotient), lower accuracy at individual chain links, and completed fewer long response chains (>3 links) than adults. In both procedures (SDR and IRA), the poorer performance of adolescents appeared to be related to the use of a response device that was spatially removed from reinforcer delivery. These results indicate that SDR and IRA performance can be established during the brief rodent adolescent period but that these two age groups’ performances differ. We hypothesize that adolescent behavior is more sensitive than adult behavior to the spatiotemporal distance between response device and location of reinforcer delivery.

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“…So too can employing specific experimental controls for motor function (e.g. Bailey et al, 2010) and by plotting both rate and accuracy-type measures, so that motor changes could be detected. Similar interventions should be emphasized within the context of zebrafish cognition as well, so that motoric effects do not masquerade as changes in cognition.…”

Section: Limitations Of Zebrafish In the Pharmacology Of Cognitionmentioning

confidence: 99%

Pharmacological analyses of learning and memory in zebrafish (Danio rerio)

Bailey

Oliveri

Levin

2015

Pharmacology Biochemistry and Behavior

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Over the last decade, zebrafish (Danio rerio) have become valuable as a complementary model in behavioral pharmacology, opening a new avenue for understanding the relationships between drug action and behavior. This species offers a useful intermediate approach bridging the gap between in vitro studies and traditional mammalian models. Zebrafish offer great advantages of economy compared to their rodent counterparts, their complex brains and behavioral repertoire offer great translational potential relative to in vitro models. The development and validation of a variety of tests to measure behavior, including cognition, in zebrafish has set the stage for the use of this animal for behavioral pharmacology studies. This has led to research into the basic mechanisms of cognitive function as well as screening for potential cognition-improving drug therapies, among other lines of research. As with all models, zebrafish have limitations, which spans pharmacokinetic challenges to difficulties quantifying behavior. The use, efficacy and limitations associated with a zebrafish model of cognitive function are discussed in this review, within the context of behavioral pharmacology.

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Mechanisms and performance measures in mastery-based incremental repeated acquisition: behavioral and pharmacological analyses

Abstract: Under some conditions, low doses of D: -amphetamine enhanced learning for one training procedure group. A novel dependent measure ("PQ") was a superior marker of progress on this mastery-based learning task.

Cited by 11 publications

References 36 publications

Effect size of memory deficits in mice with adult-onset P301L tau expression

Effect size of memory deficits in mice with adult-onset P301L tau expression

Spatial discrimination reversal and incremental repeated acquisition in adolescent and adult BALB/c mice

Pharmacological analyses of learning and memory in zebrafish (Danio rerio)

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