Mechanisms and Active Compounds Polysaccharides and Bibenzyls of Medicinal Dendrobiums for Diabetes Management

Abstract

BackgroundMedicinal dendrobiums are used popularly in traditional Chinese medicine for the treatment of diabetes, while their active compounds and mechanism remain unclear. This review aimed to evaluate the mechanism and active compounds of medicinal dendrobiums in diabetes management through a systematic approach.MethodsA systematic approach was conducted to search for the mechanism and active phytochemicals in Dendrobium responsible for anti-diabetic actions using databases PubMed, Embase, and SciFinder.ResultsCurrent literature indicates polysaccharides, bibenzyls, phenanthrene, and alkaloids are commonly isolated in Dendrobium genusin which polysaccharides and bibenzyls are most aboundant. Many animal studies have shown that polysaccharides from the species of Dendrobium provide with antidiabetic effects by lowering glucose level and reversing chronic inflammation of T2DM taken orally at 200 mg/kg. Dendrobium polysaccharides protect pancreatic β-cell dysfunction and insulin resistance in liver. Dendrobium polysaccharides up-regulate the abundance of short-chain fatty acid to stimulate GLP-1 secretion through gut microbiota. Bibenzyls also have great potency to inhibit the progression of the chronic inflammation in cellular studies.ConclusionPolysaccharides and bibenzyls are the major active compounds in medicinal dendrobiums for diabetic management through the mechanisms of lowering glucose level and reversing chronic inflammation of T2DM by modulating pancreatic β-cell dysfunction and insulin resistance in liver as a result from gut microbita regulation.

Effect of Abelmoschus esculentus L. Bioactive Components on Blood Parameters and Histopathological Changes in the Kidney of Diabetic Albino Rats

“…The different capital letters indicate that there are significant differences, P<0.05. The different lowercase letters indicate that there are significant differences, P<0.05 this study the polysaccharide separated from the okra plant has a good effect on reducing glucose in the blood which is in conformity with findings of Li et al (2022) who have noticed that polysaccharides from orchids provide antidiabetic effects by lowering blood glucose levels.…”

Dendrobium huoshanense C.Z.Tang et S.J.Cheng: A Review of Its Traditional Uses, Phytochemistry, and Pharmacology

“…Dendrobium is a valuable traditional Chinese medicine with a long history of medicinal use ( Li et al, 2022 ; Zhu et al, 2021 ; Niu et al, 2018 ). It was first recorded in “Shennong’s Herbal Classic” ( Chen et al, 2021 ).…”

Crosstalk between glucagon-like peptide 1 and gut microbiota in metabolic diseases

“…In mice, ingestion of prebiotics increased butyrate-producing bacteria ( 48 ), enhanced GLP-1 release ( 91 ), and improved diabetes symptoms ( 92 ). For example, dendrobium polysaccharides upregulated the abundance of Akkermansia and Parabacteroides , thereby increasing gut microbiota metabolites such as SCFAs, tryptophan, and indole to stimulate GLP-1 secretion [reviewed in reference ( 93 )]. In diabetic mice, ingestion of resveratrol enhanced GLP-1 release and modified cecal bacterial composition ( 94 ).…”