Mechanism Underlying the Protective Effect of Glycine in Energetic Disturbances in Brain Tissues under Hypoxic Conditions

Selin, A.A.; Lobysheva, N. V.; Vorontsova, O. N.; Tonshin, Anton A.; Yaguzhinsky, L. S.; Nartsissov, Yaroslav R.

doi:10.1007/s10517-012-1638-3

Cited by 10 publications

(2 citation statements)

References 11 publications

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“…In our study, upon ischemia/reperfusion, GABA and glycine were up regulated in the hippocampus and/or cortex tissues of female mice, and these observations are consistent with the previously published data by Andine et al [ 24 ] and Melani et al [ 25 ]. Both the releasing of GABA and the up-regulation of glycine represent the self-protective efforts of brain tissues against BCCAO-induced dysfunctions [ 26 – 28 ].…”

Section: Discussionmentioning

confidence: 99%

Metabolomic investigation of regional brain tissue dysfunctions induced by global cerebral ischemia

et al. 2016

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BackgroundTo get a broader view of global ischemia-induced cerebral disorders at the metabolic level, a nuclear magnetic resonance-based metabolomic study was performed to evaluate the metabolic profile changes on regional brain tissues of female and male mice upon bilateral common carotid arteries occlusion (BCCAO) operation.ResultsSignificant metabolic disorders were observed in both cerebral cortex and hippocampus tissues of the experimental mice upon global cerebral ischemic attack. Multiple amino acids were identified as the dominantly perturbed metabolites. It was also shown that although the metabolic profile change patterns in the brain tissues were quite similar in male and female BCCAO mice, metabolic disorders in the cortex tissues were more severe in the female mice than in the male mice.ConclusionsIn the present study, significant changes in amino acid metabolic pathways were confirmed in the early stage of global ischemia. Meanwhile, cerebral metabolic dysfunctions were more severe in the female BCCAO mice than in the male mice, suggesting that gender may play a role in different metabolic responses to the ischemic attack, which may provide an important hypothesis for a better understanding of the clinically observed gender-dependent pathological outcome of cerebral ischemia.Electronic supplementary materialThe online version of this article (doi:10.1186/s12868-016-0256-9) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Metabolomic investigation of regional brain tissue dysfunctions induced by global cerebral ischemia

et al. 2016

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“…1). REVIEW Сахарный диабет / Diabetes Mellitus | 289 тохондриями после гипоксии в мозге [39] и в сердце [34]. Кроме того, в тканях мозга при аноксии глицин предотвращает нарушения ультраструктуры митохондрий [40].…”

Section: глицин улучшает микроциркуляциюunclassified

Autocatalytic cycle in the pathogenesis of diabetes mellitus: biochemical and pathophysiological aspects of metabolic therapy with natural amino acids on the example of glycine

et al. 2018

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In this work systematization (classification) of biochemical and physiological processes that cause disorders in the human body during the development of diabetes mellitus is carried out. The development of the disease is considered as the interaction and mutual reinforcement of two groups of parallel processes. The first group has a molecular nature and it is associated with impairment of ROS-regulation system which includes NADPH oxidases, RAGE receptors, mitochondria, cellular peroxireductase system and the immune system. The second group has a pathophysiological nature and it is associated with impairment of microcirculation and liver metabolism. The analysis of diabetes biochemistry based on different published references yields a creation of a block diagram evaluating the disease development over time. Two types of autocatalytic processes were identified: autocatalysis in the cascade of biochemical reactions and "cross-section" catalysis, in which biochemical and pathophysiological processes reinforce each other. The developed model has shown the possibility of using pharmacologically active natural metabolite glycine as a medicine inhibiting the development of diabetes. Despite the fact that glycine is a substitute amino acid the drop in the glycine blood concentration occurs even in the early stages of diabetes development and can aggravate the disease. It is shown that glycine is a potential blocker of key autocatalytic cycles, including biochemical and pathophysiological processes. The analysis of the glycine action based on the developed model is in complete agreement with the results of clinical trials in which glycine has improved blood biochemistry of diabetic patients and thereby it prevents the development of diabetic complications.

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The role of glycine in regulated cell death

Weinberg

Bienholz

Venkatachalam

2016

Cell. Mol. Life Sci.

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The cytoprotective effects of glycine against cell death have been recognized for over 28 years. They are expressed in multiple cell types and injury settings that lead to necrosis, but are still not widely appreciated or considered in the conceptualization of cell death pathways. In this paper we review the available data on the expression of this phenomenon, its relationship to major pathophysiologic pathways that lead to cell death and immunomodulatory effects, the hypothesis that it involves suppression by glycine of the development of a hydrophilic death channel of molecular dimensions in the plasma membrane, and evidence for its impact on disease processes in vivo.

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Mechanism Underlying the Protective Effect of Glycine in Energetic Disturbances in Brain Tissues under Hypoxic Conditions

Cited by 10 publications

References 11 publications

Metabolomic investigation of regional brain tissue dysfunctions induced by global cerebral ischemia

Metabolomic investigation of regional brain tissue dysfunctions induced by global cerebral ischemia

Autocatalytic cycle in the pathogenesis of diabetes mellitus: biochemical and pathophysiological aspects of metabolic therapy with natural amino acids on the example of glycine

The role of glycine in regulated cell death

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