Mechanism underlying sevoflurane-induced protection in cerebral ischemia–reperfusion injury

Chen, Bing; Lin, Minqiu; Chen, Simiao; Chen, Weiyan; Song, Jingmei; Zhang, Yuyan

doi:10.1515/chem-2021-0045

Cited by 1 publication

(1 citation statement)

References 40 publications

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“…It is suggested that mice aged 6 days postnatally have brains that are more vulnerable than those of older mice. Another study highlighted that sevoflurane acts like a double-edged sword; on the one hand, it can cause neuroinflammation, but on the other, it has a neuroprotective effect, which also involves the mechanism of NF-κB activation (14). PSD-95 levels, a protein marker of brain plasticity, experienced a significant increase in the sevoflurane-J Cell Mol Anesth.…”

Section: Discussionmentioning

confidence: 99%

Effect of South Sulawesi Propolis in Sevoflurane Anesthesia-Induced Rat Model During Weaning Period: Study Levels of IL-6, TNF⍺, IL-10, and PSD-95 of the Prefrontal Cortex

Yolanda,

Andraini,

Goenarjo

et al. 2024

J Cell Mol Anesth

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Background: A recent study discovered that exposure to the anesthetic gas sevoflurane in the early years of life can impact cognitive function. Objectives: This study aims to investigate the effects of prolonged and repeated exposure to sevoflurane during the weaning period and whether the administration of propolis, a well-known herbal substance with anti-inflammatory properties, has a beneficial effect on inflammation and synaptic markers in the prefrontal cortex area, as well as its effect on spatial working memory function. Methods: We utilized Sprague Dawley rats aged 21 days (P21), divided into three groups: Control, sevoflurane, and sevoflurane with propolis. The exposure to sevoflurane (3%) was conducted three times for 2 hours each at P21, P23, and P25. Propolis treatments were administered orally for four weeks, starting from the first day of exposure to sevoflurane. Analyses of IL-6, TNF-alpha, and IL-10 levels were performed using ELISA at P25 and P51, while spatial working memory was measured using the spontaneous Y-maze. Results: Exposure to sevoflurane during the weaning period had no effect on IL-6, TNF-alpha, IL-10, and PSD95 levels in the prefrontal cortex, nor on working memory function. Similarly, the administration of propolis did not have any beneficial effect on these parameters. Conclusions: Prolonged and repeated exposure to sevoflurane during the weaning period did not induce neuroinflammation conditions that would affect synaptic markers and working memory function. Further studies are required to identify a dose of sevoflurane that causes detrimental effects on memory function and to explore the beneficial effects of propolis on this condition.

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Section: Discussionmentioning

confidence: 99%