Mechanism of Type I Hypersensitivity

Abstract

The increasing prevalence of allergic disorders is currently a serious problem with public health. Understanding of the mechanisms underlying allergies (type hypersensitivity or immediate reactions) will enabl a e us to improve our treatment with allergic diseases. In thi t s chapter, the features of type hypersensitivity reactions and the maj a or components involved as well as their potential roles in th t e induct d d ion and regu d lation of allergic responses are discussed. A half century ago, Gell and Coom d b m s classifi f f ed t d h t e hypersensitivity reactions into four types f f based on the immunologic mechanisms related to the symptoms in the organism (Gell and Coombs, 1963). Though this classification has many limitations since hypersensitive react y y ions always showed mixed pathological mechanisms, it is still widely accepted today a a . Here, we will present our insights on the basic mechanism of type hypersensitivity reactions. Multidisciplinary Approaches to Allergies

Artemisia spp.: An Update on Its Chemical Composition, Pharmacological and Toxicological Profiles

“…For instance, pollens from mugwort, A. vulgaris , contained allergenic substances such as profiling as well as other crossreactive allergens with immunoglobulin E (IgE) reactivity causing immediate type I allergic reactions [ 217 ]. Type I hypersensitivity involves mast cell degranulation and the release of inflammatory mediators such as histamine, causing allergic reactions such as anaphylactic shock [ 218 ]. Additionally, A. vulgaris pollens showed the highest levels of endotoxin among other collected plants across 100 locations in Europe [ 219 ].…”