Mechanism of the hardening process for a hydroxyapatite cement

Liu, Changsheng; Shen, Wei; Gu, Yanfang; Hu, Liming

doi:10.1002/(sici)1097-4636(199704)35:1<75::aid-jbm7>3.0.co;2-j

Cited by 100 publications

(72 citation statements)

References 10 publications

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“…It was concluded in one of the studies by Verlaan et al that anterior column augmentation by transpedicular balloon vertebroplasty with calcium phosphate cement (CPC) injection was safe and feasible [42]. Although both cements were suggested to be suitable vertebral bone void fillers, CPC showed superior biocompatibility, since the polymethyl methacrylate cement sometimes provoked a mild inflammatory reaction in the surrounding tissue [24,25,41]. The purpose of the present study was to demonstrate the feasibility and safety of balloon vertebroplasty with poly methylmethacrylate, in addition to posterior short-segment reduction and fixation in 16 patients with traumatic lumbar burst fractures.…”

Section: Introductionmentioning

confidence: 99%

Short segment pedicle screw instrumentation and augmentation vertebroplasty in lumbar burst fractures: an experience

Afzal¹,

Saleem²,

Dhar³

2008

Eur Spine J

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To assess the efficacy and feasibility of vertebroplasty and posterior short-segment pedicle screw fixation for the treatment of traumatic lumbar burst fractures. Short-segment pedicle screw instrumentation is a well described technique to reduce and stabilize thoracic and lumbar spine fractures. It is relatively a easy procedure but can only indirectly reduce a fractured vertebral body, and the means of augmenting the anterior column are limited. Hardware failure and a loss of reduction are recognized complications caused by insufficient anterior column support. Patients with traumatic lumbar burst fractures without neurologic deficits were included. After a short segment posterior reduction and fixation, bilateral transpedicular reduction of the endplate was performed using a balloon, and polymethyl methacrylate cement was injected. Pre-operative and post-operative central and anterior heights were assessed with radiographs and MRI. Sixteen patients underwent this procedure, and a substantial reduction of the endplates could be achieved with the technique. All patients recovered uneventfully, and the neurologic examination revealed no deficits. The postoperative radiographs and magnetic resonance images demonstrated a good fracture reduction and filling of the bone defect without unwarranted bone displacement. The central and anterior height of the vertebral body could be restored to 72 and 82% of the estimated intact height, respectively. Complications were cement leakage in three cases without clinical implications and one superficial wound infection. Posterior short-segment pedicle fixation in conjunction with balloon vertebroplasty seems to be a feasible option in the management of lumbar burst fractures, thereby addressing all the three columns through a single approach. Although cement leakage occurred but had no clinical consequences or neurological deficit.

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Section: Introductionmentioning

confidence: 99%

Short segment pedicle screw instrumentation and augmentation vertebroplasty in lumbar burst fractures: an experience

Afzal¹,

Saleem²,

Dhar³

2008

Eur Spine J

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“…Newly precipitated particles should be HAp since previous reports have shown fine needle-like HAp forms and links the fed CP powders to each other during setting just after their mixing. 13) The amount of precipitation increased with increasing immersion period (Fig. 5(b, d)).…”

Section: Resultsmentioning

confidence: 99%

Control of setting behavior of calcium phosphate paste using gelatinized starch

Kawai

Fujisawa

Suzuki

et al. 2010

J. Ceram. Soc. Japan

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A new type of calcium phosphate (CP) paste that retains plasticity during kneading and sets promptly under a physiological condition was successfully prepared by mixing Ca 4 O(PO 4 ) 2 (TTCP) and CaHPO 4 (DCPA) (CP powders) at 67 mass % with a gelatinized wheat starch. This paste retained plasticity because the gelatinized starch layer on the surfaces of the CP particles suppressed the rapid reaction between the CP powders. When the paste was soaked in a tris-buffered NaCl solution (TRIS), the starch layer loosened and the reaction between CP powders to form hydroxyapatite (HAp) took place at a considerable rate. The setting was found to start at 5 hours after the soaking in TRIS and proceed from the surface to the interior portion of the paste. The maximum compressive strength, 5.7 MPa which is close to that of human cancellous bone, was attained. All the pastes containing CP powders prepared in this study formed bone-like apatite on their surfaces within 1 day after being soaked in a simulated body fluid (SBF, at 310 K), independent of the CP powders content. These pastes can be stored retaining the plasticity as desired even after 3 weeks in vacuo under a cool (³277 K) condition without precipitating HAp. This material is expected to be one of the candidates for an easy-handling and highly bioactive calcium phosphate bone paste.

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“…[16][17][18] It is generally accepted that the setting mechanism of TTCP/DCPA-based CPC involves formation of apatite crystals. 8,[19][20][21][22][23] Ishikawa and Asaoka 21) indicated that the dissolved calcium and phosphate ions from both powders in water are precipitated in the form of hydroxyapatite (HA) on the powder surface. Brown and Fulmer 19) suggested that, in TTCP/DCPA-based CPC, only the earliest nuclei can have a stoichiometric HA composition.…”

Section: Introductionmentioning

confidence: 99%

Transmission Electron Microscopic Study of Tetracalcium Phosphate Surface-Treated in Diammonium Hydrogen Phosphate Solution

Wang

Lin

2005

Mater. Trans.

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The present study investigates the changes in microstructure and microchemistry (particularly Ca/P ratio) during whisker formation on the surface of a monolithic TTCP powder in a basic phosphoric acid solution. The XRD results indicate that when TTCP powder was treated for 10 min or less in (NH 4 ) 2 HPO 4 solution, the monolithic TTCP phase remains unchanged. When treated for 30 min, apatite whiskers appear, which continue to grow with treating time. When treated for 24 h, the apatite phase becomes dominant. TEM results show that on the surface of 1 min-treated TTCP are observed a large amount of globular-shaped fine particles which are substantially amorphous with an average Ca/P ratio of about 1.2. When treated for 10 min, whiskers primarily having a crystal structure of TTCP with an average Ca/P ratio of about 2.1 are observed to grow radially from TTCP surface. With time the whiskers continue to grow in length and width. The whiskers on 24 h-treated surface become Ca-rich apatite with an average Ca/P ratio of about 1.8. Both TTCP and apatite whiskers are essentially non-stoichiometric in chemistry.

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Mechanism of the hardening process for a hydroxyapatite cement

Cited by 100 publications

References 10 publications

Short segment pedicle screw instrumentation and augmentation vertebroplasty in lumbar burst fractures: an experience

Short segment pedicle screw instrumentation and augmentation vertebroplasty in lumbar burst fractures: an experience

Control of setting behavior of calcium phosphate paste using gelatinized starch

Transmission Electron Microscopic Study of Tetracalcium Phosphate Surface-Treated in Diammonium Hydrogen Phosphate Solution

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