Mechanism of piperine in affecting apoptosis and proliferation of gastric cancer cells via ROS‐mitochondria‐associated signalling pathway

Li, Guo; Yang, Yi; Sheng, Yongjia; Wang, Jin; Ruan, Shuiliang; Han, Chenyang

doi:10.1111/jcmm.16891

Cited by 25 publications

(15 citation statements)

References 25 publications

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“…Pip mechanism induced apoptosis was correlated with ROS formation, led to induce mitochondrial damage along with protein-related apoptosis induction including Bax, cytochrome c, caspase 9 and caspase 3. 25 Interestingly, Pip is also known to augment the bioavailability of some drugs by inhibiting drug metabolism or by increasing absorption. Pip with 5-fluorouracil (5-FU) augmented the anticancer activity of 5-FU and decreased the side effects.…”

Section: The Effects Of Pip On Apoptosis Mitochondrial Function and R...mentioning

confidence: 99%

Piperine Induces Cell Death, Apoptosis and Inhibits Migration in Cholangiocarcinoma Cells

Buranrat¹,

Senggunprai²,

Prawan³

et al. 2023

Ind. J. Pharm. Edu. Res

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Background/Aim: Piperine (Pip) is an alkaloid that found from natural products and it has been reported to exert anticancer activities. Nevertheless, its anticancer effect has not yet been illustrated in cholangiocarcinoma (CCA) cells. In this work will be explored the Pip effects on two CCA cells and studied the underlying molecular mechanism. Materials and Methods: The KKU-100 and KKU-M452 cells proliferation were detected by sulforhodamine B assay, colony formation, and flow cytometric method. Migratory ability was explored via the wound healing and Transwell chamber model. Apoptosis was discovered through double staining of PI and Annexin V-FITC dye. JC-1 dye, and DCF-DA staining by flow cytometry. Results: The results revealed that Pip induced CCA cells death by a dose-and time-dependent along with inhibiting colony formation in KKU-100 cells. Following cell cycle arrest, treatment with Pip arrested the cell cycle distribution at G0/G1 phase in KKU-100 and S to G2/M phase in KKU-M452 cells. Furthermore, cell migration revealed that Pip suppressed cell migration in a dose-dependent manner. Apoptosis was significant detected by flow cytometry showed that Pip induced late apoptosis in these two CCA cells. The mechanism was indicated that Pip treatment also decreased mitochondrial membrane potential and increased ROS formation. Conclusion: Therefore, Pip may useful for prevention and treatment of CCA.

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Section: The Effects Of Pip On Apoptosis Mitochondrial Function and R...mentioning

confidence: 99%

Piperine Induces Cell Death, Apoptosis and Inhibits Migration in Cholangiocarcinoma Cells

Buranrat¹,

Senggunprai²,

Prawan³

et al. 2023

Ind. J. Pharm. Edu. Res

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show abstract

“…PIP consists of 2 heterocycles linked by an aliphatic diene system, a structure that enables PIP to modulate multiple targets 100 . PIP exerts anti-tumor effects through a variety of mechanisms, such as inducing G1 cell cycle arrest 101 , inducing abnormal DNA structure, inducing ROS production and consequently disrupting redox homeostasis 102 , inhibiting tumor angiogenesis 103 , and inducing tumor cell autophagy. 104 .…”

Section: Dna Damagementioning

confidence: 99%

Anti-tumor pharmacology of natural products targeting mitosis

et al. 2022

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Cancer has been an insurmountable problem in the history of medical science. The uncontrollable proliferation of cancer cells is one of cancer’s main characteristics, which is closely associated with abnormal mitosis. Targeting mitosis is an effective method for cancer treatment. This review summarizes several natural products with anti-tumor effects related to mitosis, focusing on targeting microtubulin, inducing DNA damage, and modulating mitosis-associated kinases. Furthermore, the main disadvantages of several typical compounds, including drug resistance, toxicity to non-tumor tissues, and poor aqueous solubility and pharmacokinetic properties, are also discussed, together with strategies to address them. Improved understanding of cancer cell mitosis and natural products may pave the way to drug development for the treatment of cancer.

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“…On the human bone marrow (K-562 leukemic cells) piperine induces anticancer effects. The fight against tumor cancer lines is in a dose-dependent manner, in which the mechanism of action is associated with mitochondrial Aurora Mocanu, Maria Tomoaia-Cotisel damage, increased reactive oxygen species and expression of key proteins (Bcl -2, Bax, Cyt -c, Caspase -9 and Caspase -3) affected [19][20][21][22].…”

Section: Fig 1 Bioactive Compounds From Plantsmentioning

confidence: 99%

Interaction of Bioactive Compounds With Ceramic Materials – A Review

PALTINEAN¹,

Tomoaia²,

RACZ³

et al. 2022

AnnalsARSciPhysChem

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This review examines the interaction between silymarin (SIL) and other plant-based bioactive compounds such as curcumin (CCM), piperine (PIP), resveratrol (RES), and icariin (ICA). Their combination revealed synergistic effects on colon (HCT116), breast (T47D) tumor cells, hepatocellular carcinoma, and periodontal disease. The review also addresses the interaction between these plant extracts with ceramic materials such as hydroxyapatite (HAP) and carotenoids with concrete examples of biomedical applications. Silymarin’s interaction with chemotherapeutic drugs (doxorubicin-DOX, paclitaxel-PCT and 5-Fluorouracil-5-FLU) and gold nanoparticles-GNPs and silver nanoparticles-SNPs is also debated. All these combinations can form composites of major importance in the biomedical field and to contribute significantly to orthopedic surgery where materials are needed for implants that face severe infections. This short review highlights the variety of multifunctional nanoparticles that open new opportunities in cancer treatment and the need to use the Langmuir Blodgett Technique that mimics the biological membrane and provides rich medical information.

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Mechanism of piperine in affecting apoptosis and proliferation of gastric cancer cells via ROS‐mitochondria‐associated signalling pathway

Cited by 25 publications

References 25 publications

Piperine Induces Cell Death, Apoptosis and Inhibits Migration in Cholangiocarcinoma Cells

Piperine Induces Cell Death, Apoptosis and Inhibits Migration in Cholangiocarcinoma Cells

Anti-tumor pharmacology of natural products targeting mitosis

Interaction of Bioactive Compounds With Ceramic Materials – A Review

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