Abstract:Background/Aim: Piperine (Pip) is an alkaloid that found from natural products and it has been reported to exert anticancer activities. Nevertheless, its anticancer effect has not yet been illustrated in cholangiocarcinoma (CCA) cells. In this work will be explored the Pip effects on two CCA cells and studied the underlying molecular mechanism. Materials and Methods: The KKU-100 and KKU-M452 cells proliferation were detected by sulforhodamine B assay, colony formation, and flow cytometric method. Migratory abi… Show more
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