Mechanism of Pain in Disc Disease

Simonetti, L.; Agati, R.; Cenni, P.; Santis, Francesco De; Leonardi, Marco

doi:10.1177/197140090101400214

Cited by 14 publications

(23 citation statements)

References 10 publications

(4 reference statements)

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“…Nella patogenesi del dolore sono ritenuti invece predominanti fattori meccanici indiretti vasculo-mediati (disturbi del trofismo del nervo da compressione su vasi afferenti arteriosi e/o da stasi venosa) e la reazione infiammatoria neurale e perineurale (sia di tipo cellulo-mediato che bioumorale, quest'ultima sostenuta da mediatori A B D C chimici dell'infiammazione quali prostaglandine e leucotrieni) 12 . Ricordiamo che le stesse radici nervose e i nervi spinali sono innervati da nervi nervorum.…”

Section: Risultati E Discussioneunclassified

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Potenzialità delle sequenze fat suppression e del gadolinio nello studio RM della patologia degenerativa lombare

D’Aprile¹,

Tarantino

Strada

et al. 2002

Rivista di Neuroradiologia

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RIASSUNTO -Le lombalgie e lombosciatalgie risultano estremamente frequenti nella popolazione. Il dolore viene attribuito solitamente alla patologia degenerativa discale, particolarmente alle ernie discali, ma le strutture della colonna potenzialmente in grado di determinare dolore sono numerose: dischi, osso, tendini, legamenti, faccette articolari, muscoli.L'esame RM deve pertanto valutare con attenzione non soltanto il complesso somato-discale, ma anche gli elementi posteriori della colonna. Le sequenze T2 Fat-suppressed ed eventualmente T1 Fat-suppressed dopo somministrazione di mdc, nella nostra esperienza risultano di elevata capacità diagnostica nella patologia degenerativa della colonna, in particolare nel caso in cui l'esame RM convenzionale non mostri una chiara causa del dolore. SUMMARY -Most people will experience low back pain and leg pain during their lifetime. Pain is commonly attributed to degenerative disc disease, particularly herniated disc, but many different structures in the spine can "degenerate" and produce pain: discs, bone, tendons, ligaments, facet joints, muscles.MR examination must evaluate both anterior and posterior elements of the spinal column. Fat-suppressed T2-weighted sequences and eventually Fat-suppressed T1-weighted images after administration of contrast medium may be helpful, especially when conventional MR study fails to show the source of pain.

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Section: Risultati E Discussioneunclassified

“…Tali alterazioni possono concorrere in varia misura nel determinare una stenosi del canale vertebrale e/o dei forami di coniugazione, nonché situazioni di instabilità della colonna, che aggravano il quadro clinico 4,11,12,14 .…”

Section: Introduzioneunclassified

Potenzialità delle sequenze fat suppression e del gadolinio nello studio RM della patologia degenerativa lombare

D’Aprile¹,

Tarantino

Strada

et al. 2002

Rivista di Neuroradiologia

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“…Unless differently stated, the procedures used in the present study are identical to the ones described in part I of this series. 1 Peptide concentrations in the experiments ranged from 6.54 ϫ 10 Ϫ4 to 5.09 ϫ 10 Ϫ2 M and were calculated by weight. The pro-OT/Np related peptides (Table I) are numbered according to Rholam et al 11…”

Section: Methodsmentioning

confidence: 99%

“…The FTIR spectra of peptides XXIII and [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] before (XXIII H , [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] H ) and after deuteration (XXIII D , [1][2][3][4][5][6][7][8][9][10][11][12][13]…”

Section: Ftir Spectra In Dmso and Dmso/d 2 Ounclassified

“…A new Fourier transform infrared (FTIR) based method for the conformational analysis of short peptides in solution was proposed. 1 The method, while using traditional tools for the analysis of FTIR spectra such as band-narrowing (BN) and curve-fitting (CF) procedures, presents substantial innovations with respect to methods already employed by Byler and Susi [2][3][4] and others. [5][6][7] Indeed, the assignment of the absorption due to peptide groups participating in secondary structures is based on the direct measurement of the isotopic effect induced on the groups involved in intramolecular H-bonds in the presence of organic solvents incapable of donating hydrogens.…”

Section: Introductionmentioning

confidence: 99%

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New Fourier transform infrared based computational method for peptide secondary structure determination. II. Application to study of peptide fragments reproducing processing site of ocytocin–neurophysin precursor

Simonetti

Bello

2001

Biopolymers

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A new method for the quantitative determination of the percentage of intramolecular H-bonds, based on Fourier transform infrared techniques, is applied to the conformational analysis of a series of synthetic peptides spanning the processing site of the ocytocin and neurophysin precursor. Even though the method uses traditional tools such as Fourier self-deconvolution, the Nth derivative, and curve-fitting procedures for the analysis of the spectra, the assignment of the absorptions due to peptide groups participating into secondary structures is based on the direct observation and quantification of the isotopic effect induced on the groups participating in intramolecular H-bonds in the presence of organic solvents. This permits the quantification of the different populations of molecules containing intramolecular H-bonds involved in beta-turns and alpha-helices. The results are consistent with those previously obtained by NMR techniques in the same solvent systems.

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Percutaneous ozone nucleolysis for lumbar disc herniation

et al. 2018

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PurposeAll percutaneous minimally invasive disc treatments are typically indicated to contained disc herniations. Our study’s aim is to evaluate prospectively the efficacy of ozone nucleolysis in the treatment of either contained or uncontained lumbar disc herniations.MethodsFifty-two patients, aged 27–87 years, with symptomatic herniated lumbar discs, without migration, sequestration, or severe degenerative disc changes, who failed conservative treatment, were included in our study. The patients underwent fluoroscopic-guided intradiscal oxygen-ozone mixture injection (5 ml) at a concentration of 27–30 μg/ml and periradicular injection of the same O2-O3 mixture (10 ml), steroid (1 ml), and local anesthetic (1 ml). Clinical outcomes were evaluated, based on the Oswestry Disability Index (ODI) and pain intensity (0–5) scale results, obtained initially and at 2- and 6-month controls. Our results were analyzed by ANOVA and chi-squared (χ2) tests.ResultsOur initial results obtained at 2-month control were promising, indicating a significant decrease in pain disability and intensity in 74% (37) and 76% (38) of the patients respectively, and minimally increased to 76% (38) and 78% (39) at 6-month control (P < 0.001 and CI 99.9%). The mean preprocedure ODI and pain intensity scores were 35 ± 14.36 and 2.38 ± 0.90, respectively, which were reduced to 19.36 ± 13.12 and 1.04 ± 0.92 at 6-month control. Our failure had been mostly related to long symptoms duration of more than 1 year. No complications were recorded.ConclusionOzone nucleolysis is a safe cost-effective minimally invasive technique for treatment of contained and uncontained lumbar disc herniations.

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Mechanism of Pain in Disc Disease

Cited by 14 publications

References 10 publications

Potenzialità delle sequenze fat suppression e del gadolinio nello studio RM della patologia degenerativa lombare

Potenzialità delle sequenze fat suppression e del gadolinio nello studio RM della patologia degenerativa lombare

New Fourier transform infrared based computational method for peptide secondary structure determination. II. Application to study of peptide fragments reproducing processing site of ocytocin–neurophysin precursor

Percutaneous ozone nucleolysis for lumbar disc herniation

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