Doppler echocardiography and color Doppler flow imaging were used to
assess the results of percutaneous mitral valvotomy in 293 consecutive
patients aged 16-86 years (mean age 52.4 ± 13.5). Doppler examinations
were performed the day before as well as within 2 days and 3 months after
valvotomy. The first 161 procedures were carried out using the double-balloon
technique and the last 132 using the Inoue technique. Mitral valve area,
calculated according to the Gorlin formula, increased on average from 1.0 ±
0.3 to 2.0 ± 0.5 cm^2 (p < 0.0001) and the mean gradient dropped on average
from 12.5 ± 4 to 5 ± 2 mm Hg (p < 0.0001). Grade 1+ mitral regurgitation
was present in 85 patients (29%) before valvotomy when estimated from left
ventricular angiography. After valvotomy, it worsened to grade 2+ in 19
patients (6%) and to grade 3+ or 4+ in 5 cases (1.7%). Grade 1+, 2+ and 3+
mitral regurgitation appeared in 28 (9.5%), 5 (1.7%) and 6 patients (2%),
respectively. Grade 1+ mitral regurgitation was detected by color Doppler in
159 patients (54%) before valvotomy. After the procedure, it worsened to
grade 2+ in 16 patients (5%) and to grade 3+ or 4+ in 5 patients (1.7%). Grade
1+, 2+ and 3+ mitral regurgitation appeared in 30 (10%), 6 (2%) and 2 (0.7%)
patients, respectively. Mitral regurgitation disappeared after valvotomy in 21
patients (7.2%). The specificity of color Doppler in the detection of mitral
regurgitation was questionable when compared to contrast angiography
(44%), perhaps because color Doppler may be more sensitive than left ventriculography
in the diagnosis of mild mitral regurgitation. All in all, mitral
regurgitation quantification determined by color Doppler correlated well with
contrast angiography data, with a discrepancy of more than 1 grade in only 6
patients. The location and mechanism of mitral regurgitation were determined
using color Doppler. Regurgitation was central in most cases; it was
sometimes located on one commissure or on both in 26 cases. Color Doppler
visualized an atrial septal defect in 115 patients (39%) on day 2, which persisted
in 36 of 96 patients reexamined 3 months later. A shunt inversion was
present during deep inhalation in 1 case. No correlation was found between
the persistence or disappearance of the shunt and the results of mitral valvotomy.