Mechanism of formation, characterization and cytotoxicity of green synthesized zinc oxide nanoparticles obtained from Ilex paraguariensis leaves extract

Bandeira, Marina; Possan, André Luís; Pavin, Sandra S.; Raota, Camila Suliani; Vebber, Mário César; Giovanela, Marcelo; Roesch‐Ely, Mariana; Devine, Declan M.; Crespo, Janaína da Silva

doi:10.1016/j.nanoso.2020.100532

Cited by 32 publications

(22 citation statements)

References 76 publications

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“…This shows that the observed shifts in FTIR spectra is because of the incorporation of chromium atoms in the ZnO lattice. FTIR spectra of pure ZnO and Cr doped ZnO nanoparticles investigated in this work are in excellent agreement with previously recorded values [56][57][58].…”

Section: Functional Group Analysissupporting

confidence: 91%

Structural and thermal properties of pure and chromium doped zinc oxide nanoparticles

et al. 2021

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Pure ZnO and Cr-doped ZnO nanoparticles have been synthesized via a facile chemical co-precipitation route and their structural, thermal characteristics were discussed systematically. In the experimental producer, the doping concentration has varied the range, 0.05–0.1 M, while calcined at 600 °C. The influence of Cr-doping on the physical characteristics of ZnO nanoparticles was investigated and addressed. As-prepared samples were analyzed via XRD, FTIR, TGA/DTA, BET, and ICP-MS. XRD analysis shows that ZnO and Cr doped ZnO nanoparticles with average particle sizes between 23 and 39 nm were successfully developed with hexagonal wurtzite structure. The FTIR spectroscopy analysis confirms the existence of chromium in the doped ZnO nanoparticles and the formation of ZnO. The TGA/DTA analysis shows that Cr–ZnO nanoparticles are more thermally stable than ZnO nanoparticles. Moreover, the dopant concentration has been analyzed via ICP-MS and showed a good agreement with the expected chromium concentration. The BET surface area measurement shows that 176.25 m2/g and 287.17 m2/g for un-doped ZnO, and 0.1 M Cr-doped ZnO nanoparticles, respectively. Hence, doping of Cr enhances the surface area and thermal stability. Thus, Cr–ZnO nanoparticles show good thermal stability, and high surface area, which is an excellent characteristices of nanomaterials. Graphic abstract

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Section: Functional Group Analysissupporting

confidence: 91%

Structural and thermal properties of pure and chromium doped zinc oxide nanoparticles

et al. 2021

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“…the incorporation process of ZnONPs did not affect the morphology and size of the fiber mat, as it maintained its characteristics. The green synthesized ZnONPs were characterized in a preview work and have a spherical shape and an average size of 18 nm [ 28 ].…”

Section: Resultsmentioning

confidence: 99%

“…The green synthesized ZnONPs were prepared as described in a previous work [ 28 ]. Briefly, to obtain the plant extract, 100 g L −1 of IP leaves, previously cleaned, dried (1.5 h at 60 °C) and ground in a mill, were heated at 50 °C and stirred during 20 min with two different solutions: pure distilled water and a 50% ( v / v ) ethanol/water solution (ethanolic extract).…”

Section: Methodsmentioning

confidence: 99%

“…The ZnONPs were synthesized using Ilex paraguariensis leaves via a sustainable process, which is beneficial not only regarding environmental preservation but also to obtain a product with promising low cytotoxicity and side effects, as no hazardous material is used in the process [ 27 , 28 ]. Literature reports the synthesis of ZnONPs using different plants [ 29 , 30 , 31 , 32 , 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial PAA/PAH Electrospun Fiber Containing Green Synthesized Zinc Oxide Nanoparticles for Wound Healing

et al. 2021

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Wound infections are the main complication when treating skin wounds. This work reports a novel antimicrobial material using green synthesized zinc oxide nanoparticles (ZnONPs) incorporated in polymeric fibers for wound healing purposes. ZnONPs are a promising antimicrobial nanomaterial with high activity against a range of microorganisms, including drug-resistant bacteria. The electrospun fibers were obtained using polyacrylic acid (PAA) and polyallylamine hydrochloride (PAH) and were loaded with ZnONPs green synthesized from Ilex paraguariensis leaves with a spherical shape and ~18 nm diameter size. The fibers were produced using the electrospinning technique and SEM images showed a uniform morphology with a diameter of ~230 nm. EDS analysis proved a consistent dispersion of Zn in the fiber mat, however, particle agglomerates with varying sizes were observed. FTIR spectra confirmed the interaction of PAA carboxylic groups with the amine of PAH molecules. Although ZnONPs presented higher antimicrobial activity against S. aureus than E. coli, resazurin viability assay revealed that the PAA/PAH/ZnONPs composite successfully inhibited both bacteria strains growth. Photomicrographs support these results where bacteria clusters were observed only in the control samples. The PAA/PAH/ZnONPs composite developed presents antimicrobial activity and mimics the extracellular matrix morphology of skin tissue, showing potential for wound healing treatments.

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“…The various biomolecules present in these extracts reduce and stabilize the nanoparticles (Groiss et al 2017). Few examples of green resources used for the preparation of ZONPs include Linum usitatissimum (Alkasir et al 2020), Moringa oleifera (Letsholathebe et al 2020), Salvadora persica (Alharthi et al 2020), Ilex paraguariensis (Bandeira et al 2020), Sambucus spp. (Alamdari et al 2020) Abelmoschus esculentus (Mirgane et al 2020), Peltophorum pterocarpum (Pai et al 2019a), Cyanometra ramiflora (Varadavenkatesan et al 2019) and Calliandra haematocephala (Vinayagam et al 2020b).…”

Section: Introductionmentioning

confidence: 99%

Synthesis of photocatalytic zinc oxide nanoflowers using Peltophorum pterocarpum pod extract and their characterization

et al. 2021

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Zinc oxide nanoflowers (ZnONFs) were prepared by employing the pod extract of Peltophorum pterocarpum as a green resource and characterized by various methods. UV–vis spectrum displayed a peak at 361 nm which confirmed the formation of ZnO nanoparticles. The optical band gap was calculated as 3.43 eV. FE-SEM images exposed the flower-like morphology and EDX portrayed strong signals for Zn and O. XRD studies substantiated signature peaks for the wurtzite phase of ZnONFs and the lattice parameters matched well with the literature. Mesoporous nature was confirmed by BET analysis which yielded a high specific surface area of 19.61 m2/g. FTIR bands at 420.48 and 462.92 cm−1affirmed the Zn and O bonding vibrations. The photocatalytic potential of the ZnONFs was successfully examined for the removal of methylene blue dye under natural solar light. The experimental data were fitted to Langmuir–Hinshelwood’s first-order equation and the kinetic constant was calculated as 0.0114 min–1.

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Mechanism of formation, characterization and cytotoxicity of green synthesized zinc oxide nanoparticles obtained from Ilex paraguariensis leaves extract

Cited by 32 publications

References 76 publications

Structural and thermal properties of pure and chromium doped zinc oxide nanoparticles

Structural and thermal properties of pure and chromium doped zinc oxide nanoparticles

Antimicrobial PAA/PAH Electrospun Fiber Containing Green Synthesized Zinc Oxide Nanoparticles for Wound Healing

Synthesis of photocatalytic zinc oxide nanoflowers using Peltophorum pterocarpum pod extract and their characterization

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