Mechanism of Enhancement Effect of Dendrimer on Transdermal Drug Permeation through Polyhydroxyalkanoate Matrix

Wang, Zhixiong; Itoh, Yoshiaki; Hosaka, Yoshifumi; Kobayashi, Ichiro; Nakano, Yoshihisa; Maeda, Isamu; Umeda, Fusako; Yamakawa, Junji; Nishimine, Mari; Suenobu, Tomoyoshi; Fukuzumi, Shunichi; Kawase, Masaya; Yagi, Kiyohito

doi:10.1263/jbb.96.537

Cited by 7 publications

(6 citation statements)

References 15 publications

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“…In a separate experiment, the same team reported the mechanism of enhancement effect of dendrimer on drug penetration through the skin in TDDS 111. G3 PAMAM dendrimer with amino groups and G2.5 PAMAM dendrimer with carboxyl groups were used.…”

Section: Applications In Different Routes Of Drug Administrationmentioning

confidence: 99%

Dendrimers as Drug Carriers: Applications in Different Routes of Drug Administration

Cheng

et al. 2008

Journal of Pharmaceutical Sciences

409

188

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Section: Applications In Different Routes Of Drug Administrationmentioning

confidence: 99%

Dendrimers as Drug Carriers: Applications in Different Routes of Drug Administration

Cheng

et al. 2008

Journal of Pharmaceutical Sciences

409

188

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“…Thus, the authors concluded that PHA-dendrimer matrix reached the clinical aim and could be developed as a useful delivery system for clinical TDDS. In a separate experiment, the same team reported the mechanism of enhancement effect of dendrimer on drug penetration through the skin in TDDS 34 . G3 PAMAM dendrimer with amino groups and G2.5 PAMAM dendrimer with carboxyl groups were used.…”

Section: Dendrimers In Transdermal Drug Deliverymentioning

confidence: 99%

Unique Structures, Properties and Applications of Dendrimers

Gupta

Dubey

Mishra

2018

J. Drug Delivery Ther.

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Dendrimers are novel three dimensional, hyperbranched globular nano polymeric architectures. Attractive features like nanoscopic size, narrow polydispersity index and excellent control over molecular structure afford dendrimers with ideal drug delivery ability through encapsulating drugs in their interior or covalently conjugating drugs on their surfaces. The adaptable surface functionalization ability enables covalent conjugation of various targeting molecules onto the surface of dendrimers, thereby allowing for generation of various multifunctional nanodevices for targeted drug delivery applications. Drug delivery researchers are especially enthusiastic about possible utility of dendrimers as drug delivery tool. However, to get the maximum benefits of these novel class macromolecules, a research by collaboration is very much essential. Finally, it is one of the youngest and exciting fields of polymer researches where all branches of science can take part and hence, deserves more intensive attention. Keywords: Dendrimers, Drug Delivery, Targeting, Dual Drug Loading, PAMAM

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“…Transdermal drug delivery: PAMAM dendrimers enhanced the bioavailability of indomethacin in transdermal delivery applications. 38 Wang et al 39 reported the utilization of polyhydroxyalkanoate and G 3 PAMAM dendrimers as Transdermal drug delivery (TDDS). Cheng et al 40 investigated TDDS for anti-inflammatory drugs and concluded that the bioavailability of anti-inflammatory drugs was increased; it may be due to the facilitated skin penetration.…”

Section: Applications Of Dendrimersmentioning

confidence: 99%

Untitled

2010

IJPSR

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Dendrimers are a new class of polymeric materials. They are highly branched, monodisperse macromolecules. Structural Advantages allow dendrimers to play an important role in the fields of nanotechnology, pharmaceutical and medicinal chemistry. As a result of their unique behaviour dendrimers are suitable for a wide range of biomedical and industrial applications. The paper gives a brief review of dendrimers' physicochemical properties and their possible use in various areas of research, technology and treatment.

show abstract

Mechanism of Enhancement Effect of Dendrimer on Transdermal Drug Permeation through Polyhydroxyalkanoate Matrix

Cited by 7 publications

References 15 publications

Dendrimers as Drug Carriers: Applications in Different Routes of Drug Administration

Dendrimers as Drug Carriers: Applications in Different Routes of Drug Administration

Unique Structures, Properties and Applications of Dendrimers

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