Mechanism of Endothelial Nitric Oxide-Dependent Vasorelaxation Induced by Wine Polyphenols in Rat Thoracic Aorta

Andriambeloson, Emile; Stoclet, Jean Claude; Andriantsitohaina, Ramaroson

doi:10.1097/00005344-199902000-00011

Cited by 113 publications

(84 citation statements)

References 27 publications

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“…This result is well consistent with report that PCRW produced the endothelium-NO-dependent relaxation through an extracellular Ca 2＋ -dependent mechanism (Andriambeloson et al, 1999). Amongst the different classes of polyphenolic compounds present in PCRW, anthocyanins and oligomeric condensed tannins had the same pharmacological profile as PCRW (Andriambeloson et al, 1998).…”

Section: Discussionsupporting

confidence: 92%

Resveratrol Inhibits Nicotinic Stimulation-Evoked Catecholamine Release from the Adrenal Medulla

Woo

Lim

2008

Korean J Physiol Pharmacol

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Resveratrol has been known to possess various potent cardiovascular effects in animal, but there is little information on its functional effect on the secretion of catecholamines (CA) from the perfused model of the adrenal medulla. Therefore, the aim of the present study was to determine the effect of resveratrol on the CA secretion from the isolated perfused model of the normotensive rat adrenal gland, and to elucidate its mechanism of action. Resveratrol (

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Section: Discussionsupporting

confidence: 92%

Resveratrol Inhibits Nicotinic Stimulation-Evoked Catecholamine Release from the Adrenal Medulla

Woo

Lim

2008

Korean J Physiol Pharmacol

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“…Ethanol, at the same concentration as contained in red and white wines, does not cause vasorelaxation (31). RW or extracts obtained from it caused endothelium-dependent, NO-mediated vasorelaxation of rat (32) or rabbit (33) aorta preconstricted with norepinephrine. Also, in human coronary arteries and rat aortic rings in vitro, short-term incubation with RW induced FMD and increased vascular cGMP content (31).…”

Section: Discussionmentioning

confidence: 95%

The action of red wine and purple grape juice on vascular reactivity is independent of plasma lipids in hypercholesterolemic patients

Coimbra

Lage

Brandizzi

et al. 2005

Braz J Med Biol Res

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Although red wine (RW) reduces cardiovascular risk, the mechanisms underlying the effect have not been identified. Correction of endothelial dysfunction by RW flavonoids could be one mechanism. We measured brachial artery reactivity by high-resolution ultrasonography, plasma lipids, glucose, adhesion molecules (ICAM-1 and VCAM), and platelet function in 16 hypercholesterolemic individuals (8 men and 8 women; mean age 51.6 ± 8.1 years) without other risk factors. Twenty-four normal subjects were used as controls for vascular reactivity. Subjects randomly received RW, 250 ml/day, or purple grape juice (GJ), 500 ml/day, for 14 days with an equal wash-out period. At baseline, all 16 subjects were hypercholesterolemic (mean LDL = 181.0 ± 28.7 mg/dl) but HDL, triglycerides, glucose, adhesion molecules, and platelet function were within normal limits. Brachial artery flow-mediated dilation was significantly decreased compared to controls (9.0 ± 7.1 vs 12.1 ± 4.5%; P < 0.05) and increased with both GJ (10.1 ± 7.1 before vs 16.9 ± 6.7% after: P < 0.05) and RW (10.1 ± 6.4 before vs 15.6 ± 4.6% after; P < 0.05). RW, but not GJ, also significantly increased endothelium-independent vasodilation (17.0 ± 8.6 before vs 23.0 ± 12.0% after; P < 0.01). GJ reduced ICAM-1 but not VCAM and RW had no effect on either molecule. No significant alterations were observed in plasma lipids, glucose or platelet aggregability with RW or GJ. Both RW and GJ similarly improved flow-mediated dilation, but RW also enhanced endothelium-independent vasodilation in hypercholesterolemic patients despite the increased plasma cholesterol. Thus, we conclude that GJ may protect against coronary artery disease without the additional negative effects of alcohol despite the gender.

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“…This role of Ca 2 + is supported by the relaxation of rat aorta (64) and the increase in Ca 2 + concentration in bovine aortic endothelial cells (65) caused by a polyphenolic extract from alcohol-free red wine and by delphinidin, which are both Ca 2 + dependent effects. Furthermore, wine polyphenols are unable to increase Ca 2 + concentration in smooth muscle cells, indicating the selectivity of this effect (65) .…”

Section: Carotenoids: Flavonoids: Cvd: Laser Doppler Imagingmentioning

confidence: 94%

Effects of chronic and acute consumption of fruit- and vegetable-puree-based drinks on vasodilation, risk factors for CVD and the response as a result of theeNOSG298T polymorphism

et al. 2009

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The average UK adult consumes less than three portions of fruit and vegetables daily, despite evidence to suggest that consuming five portions daily could help prevent chronic diseases. It is recommended that fruit juice should only count as one of these portions, as juicing removes fibre and releases sugars. However, fruit juices contain beneficial compounds such as vitamin C and flavonoids and could be a useful source of dietary phytochemicals. Two randomised controlled cross-over intervention studies investigating the effects of chronic and acute consumption of commercially-available fruit-and vegetable-puree-based drinks (FVPD) on bioavailability, antioxidant status and CVD risk factors are described. Blood and urine samples were collected during both studies and vascular tone was measured using laser Doppler imaging. In the chronic intervention study FVPD consumption was found to significantly increase dietary carotenoids (P = 0 . 001) and vitamin C (P = 0 . 003). Plasma carotenoids were increased (P = 0 . 001), but the increase in plasma vitamin C was not significant. There were no significant effects on oxidative stress, antioxidant status and other CVD risk factors. In the acute intervention study FVPD were found to increase total plasma nitrate and nitrite (P = 0 . 001) and plasma vitamin C (P = 0 . 002). There was no effect on plasma lipids or uric acid, but there was a lower glucose and insulin peak concentration after consumption of the FVPD compared with the sugar-matched control. There was a trend towards increased vasodilation following both chronic and acute FVPD consumption. All volunteers were retrospectively genotyped for the eNOS G298T polymorphism and the effect of genotype on the measurements is discussed. Overall, there was a non-significant trend towards increased endothelium-dependent vasodilation following both acute and chronic FVPD consumption. However, there was a significant time · treatment effect (P < 0 . 05) of acute FVPD consumption in individuals with the GG variant of the eNOS gene. Carotenoids: Flavonoids: CVD: Laser Doppler imagingCVD is one of the major causes of death in Europe and is responsible for 4 . 3 · 10 6 deaths each year across the continent (1) . One of the emerging risk factors for CVD is dysfunction of the endothelium (2,3) , which is characterised by a reduction in the bioavailability of vasodilators, predominantly NO, endothelium-derived hyperpolarizing factor and prostacyclin, and an increase in endothelium-derived vasoconstrictors, e.g. thromboxane A 2 , PGH 2 and endothelin 1 (2) . Endothelial dysfunction can be assessed by measuring enhanced and maintained endothelial activation and impaired endothelium-dependent vasodilation (4) .Endothelial activation is determined by an increase in the plasma concentrations of soluble cell adhesion molecules, such as intercellular adhesion molecule-1, vascularAbbreviations: atRA, all-trans-retinoic acid; eNOS, endothelial NO synthase; FVPD, fruit-and vegetable-puree-based drinks.

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Mechanism of Endothelial Nitric Oxide-Dependent Vasorelaxation Induced by Wine Polyphenols in Rat Thoracic Aorta

Cited by 113 publications

References 27 publications

Resveratrol Inhibits Nicotinic Stimulation-Evoked Catecholamine Release from the Adrenal Medulla

Resveratrol Inhibits Nicotinic Stimulation-Evoked Catecholamine Release from the Adrenal Medulla

The action of red wine and purple grape juice on vascular reactivity is independent of plasma lipids in hypercholesterolemic patients

Effects of chronic and acute consumption of fruit- and vegetable-puree-based drinks on vasodilation, risk factors for CVD and the response as a result of theeNOSG298T polymorphism

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