Mechanism of delayed puberty in rats whose mothers consumedHibiscus sabdariffaduring lactation

Fractionation of stigmasterol derivative and study of the effects ofCelsia coromandelinaaerial parts petroleum ether extract on appearance of puberty and ovarian steroidogenesis in immature mice

“…In the present investigation, PECC, in a dose-dependent manner, significantly retarded the onset of puberty as it is proved by the age at vaginal opening (Elbetieha et al, 1998;Iyare et al, 2010) and appearance of first estrus (Table 1). These abnormalities in the estrus cycle 55.2 ± 0.8 81.9 ± 0.8 10.2 ± 0.7 23.9 ± 0.8 (5 mL/kg, i.p.)…”

Medicinal plants with endocrine modulating effects

“…Hibiscus sabdariffa consumption caused delayed puberty of the offspring either the mothers consumed it during pregnancy or during lactation periods (68)(69)(70) .…”