“…In the present investigation, PECC, in a dose-dependent manner, significantly retarded the onset of puberty as it is proved by the age at vaginal opening (Elbetieha et al, 1998;Iyare et al, 2010) and appearance of first estrus (Table 1). These abnormalities in the estrus cycle 55.2 ± 0.8 81.9 ± 0.8 10.2 ± 0.7 23.9 ± 0.8 (5 mL/kg, i.p.)…”