Mechanism of Corilagin interference with IL-13/STAT6 signaling pathways in hepatic alternative activation macrophages in schistosomiasis-induced liver fibrosis in mouse model

Phenylpropionamides, Piperidine, and Phenolic Derivatives from the Fruit of Ailanthus altissima

“…Corilagin was reported to possess diverse pharmacological activities such as antioxidative, anti-inflammatory, thrombolytic, antihypertensive, hepatoprotective, and antiatherogenic activities, as well as anti-tumor action in hepatocellular carcinoma, ovarian cancer, etc. [ 44 , 45 ]. Meanwhile, corilagin can reduce the cytotoxicity induced by human enterovirus 71 (EV71) and Coxsackie-virus A16 (CA16) on Vero cells and has been shown to protect against HSV1 encephalitis through inhibiting the TLR2 signaling pathways in vivo and in vitro [ 45 , 46 ].…”

Effects of corilagin on alleviating cholestasis via farnesoid X receptor‐associated pathways in vitro and in vivo

“…A maximum of five rats was kept in a single cage. The rats were maintained as described previously (Du et al, ) under standard laboratory conditions at 25 ± 2°C, 50 ± 15% relative humidity and a normal circadian period (12 h dark/12 h light cycle). The animals were provided a normal diet and water ad libitum .…”

“…Corilagin has been found to have strong antioxidant (Zhao et al, ; Jin et al, ), anti‐inflammatory (Zhao et al, ), hepatoprotective (Shiota et al, ), thrombolytic and antihypertensive (Cheng et al, ), antiatherogenic (Duan et al, ) and anti‐tumoural (Jia et al, ) properties. Corilagin can also suppress schistosomiasis liver fibrosis by regulating the IL‐13/JAK/STAT6 and miR‐21/smad7/ERK signalling pathways (Li et al, ; Yang et al, ; Du et al, ). Moreover, corilagin inhibits the expression of TNF‐α and NF‐κB (Gambari et al, ) and protects against HSV1 encephalitis by inhibiting the TLR2 signalling pathways (Guo et al, ; Guo et al, ).…”

Corilagin controls post-parasiticide schistosome egg-induced liver fibrosis by inhibiting Stat6 signalling pathway

“…After passaging cells in 6-well plates and culturing them to 70% density, the cell supernatants were removed and IL-13 and IL-4 at concentrations of 0 ng/ml, 25 ng/ml, 50 ng/ml, and 100 ng/ml were added to the wells. After 24 h, cells were harvested to detect the level of the downstream signalling molecules KLF4 and SOCS1 by quantitative real-time PCR and western blotting to determine the optimal dosage of IL-13 and IL-4 (31, 34).…”