Corilagin controls post-parasiticide schistosome egg-induced liver fibrosis by inhibiting Stat6 signalling pathway

Abstract

45This study aims to explore the effect of Corilagin (Cor) on post-parasiticide 46 schistosome egg-induced hepatic fibrosis through the Stat6 signalling pathway in vitro 47 and in vivo. Cellular and animal models were established and treated by Corilagin. 48The inhibitory effect of Corilagin was also confirmed in RAW264.7 cells in which 49Stat6 was overexpressed based on the GV367-Stat6-EGFP lentiviral vector system 50 and in which Stat6 was knock-downed by gene specific siRNAs. As a result,