Mechanism of cholangiocellular damage and repair during cholestasis

Salas-Silva, Soraya; Simoni‐Nieves, Arturo; Chávez-Rodríguez, Lisette; Gutiérrez‐Ruiz, María Concepción; Bucio, Leticia; Quiroz, Luis Enrique Gómez

doi:10.1016/j.aohep.2021.100530

Cited by 4 publications

(11 citation statements)

References 91 publications

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“…Cholangiocytes are the cells that form the bile duct epithelium. They are polarized cells with well-defined basolateral and apical membranes that express multiple receptors and channels that efficiently modify the composition of the bile [ 84 ]. Cholangiocytes are target cells in several liver diseases, including drug-induced cholestasis and vanishing bile duct syndrome [ 19 ].…”

Section: Liver Cells and Their Role In Drug-induced Toxicitymentioning

confidence: 99%

“…Enhanced cell proliferation and apoptosis are among the characteristic responses of cholangiocytes during cholestatic liver injury. Although the mechanisms of drug-induced cholangiocyte damage have not been fully elucidated, studies in experimental models of drug-induced cholestasis suggest the release of proinflammatory cytokines by hepatocytes and NPCs, and increased ROS production as potential causes of cholangiocyte injury [ 84 ].…”

Section: Liver Cells and Their Role In Drug-induced Toxicitymentioning

confidence: 99%

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In Vitro Models for Studying Chronic Drug-Induced Liver Injury

Donato

Ferrer

Tolosa

2022

IJMS

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Drug-induced liver injury (DILI) is a major clinical problem in terms of patient morbidity and mortality, cost to healthcare systems and failure of the development of new drugs. The need for consistent safety strategies capable of identifying a potential toxicity risk early in the drug discovery pipeline is key. Human DILI is poorly predicted in animals, probably due to the well-known interspecies differences in drug metabolism, pharmacokinetics, and toxicity targets. For this reason, distinct cellular models from primary human hepatocytes or hepatoma cell lines cultured as 2D monolayers to emerging 3D culture systems or the use of multi-cellular systems have been proposed for hepatotoxicity studies. In order to mimic long-term hepatotoxicity in vitro, cell models, which maintain hepatic phenotype for a suitably long period, should be used. On the other hand, repeated-dose administration is a more relevant scenario for therapeutics, providing information not only about toxicity, but also about cumulative effects and/or delayed responses. In this review, we evaluate the existing cell models for DILI prediction focusing on chronic hepatotoxicity, highlighting how better characterization and mechanistic studies could lead to advance DILI prediction.

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Section: Liver Cells and Their Role In Drug-induced Toxicitymentioning

confidence: 99%

Section: Liver Cells and Their Role In Drug-induced Toxicitymentioning

confidence: 99%

In Vitro Models for Studying Chronic Drug-Induced Liver Injury

Donato

Ferrer

Tolosa

2022

IJMS

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“…Los colangiocitos son células epiteliales alineadas para formar la primer barrera de protección contra los componentes biliares. Son provistos de un cilio primario en su cara apical el cual cuenta con receptores y canales encargados de censar la calidad de la bilis y poder regularla por la secreción de iones y agua (Salas-Silva et al, 2021).…”

Section: áCidos Biliares Y Circulaciónunclassified

“…Las enfermedades hepáticas siguen representando un serio problema de salud pública, esto en gran medida relacionado con el estilo de vida moderno caracterizado por el consumo de alcohol, enfermedades virales hepáticas, consumo elevado de alimentos ricos en grasas y sin olvidar el consumo de drogas, productos herbolarios y suplementos alimenticios que hacen del hígado un órgano susceptible al daño por su actividad biotransformante (García-Cortes et al, 2020;Salas-Silva et al, 2021).…”

Section: Enfermedad Colestásicaunclassified

“…(Isaacs-Ten et al, 2020). Las causas de la colestasis pueden ser alteraciones en la habilidad de hepatocitos o colangiocitos para la formación de la bilis clasificada como colestasis funcional o por inflamación fibrosa de los ductos biliares y la obstrucción mecánica del flujo biliar clasificadas como colestasis obstructiva (Salas-Silva et al, 2021;Slijepcevic et al, 2018).…”

Section: Colestasisunclassified

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Efecto protector del factor de crecimiento de hepatocitos (HGF) a nivel intestinal en un modelo murino de colestasis química inducida por α-Naftilisotiocianato (ANIT)

Ramírez

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manifiesto mi compromiso de mantener de forma confidencial y de no utilizar, divulgar o difundir por ningún medio, en beneficio propio o de terceros, la información, la documentación y datos de toda índole a los que tenga acceso y reciba con motivo del proyecto de investigación "Efecto protector del factor de crecimiento de hepatocitos (HGF) a nivel intestinal en un modelo murino de colestasis química inducida por α-Naftilisotiocianato (ANIT)" a desarrollar en Universidad Autónoma Metropolitana, lo anterior en términos del artículo 6, fracción V,

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Recent Advances in Intrahepatic Biliary Epithelial Heterogeneity

et al. 2022

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Biliary epithelium (i.e., cholangiocytes) is a heterogeneous population of epithelial cells in the liver, which line small and large bile ducts and have individual responses and functions dependent on size and location in the biliary tract. We discuss the recent findings showing that the intrahepatic biliary tree is heterogeneous regarding (1) morphology and function, (2) hormone expression and signaling (3), response to injury, and (4) roles in liver regeneration. This review overviews the significant characteristics and differences of the small and large cholangiocytes. Briefly, it outlines the in vitro and in vivo models used in the heterogeneity evaluation. In conclusion, future studies addressing biliary heterogeneity's role in the pathogenesis of liver diseases characterized by ductular reaction may reveal novel therapeutic approaches.

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Mechanism of cholangiocellular damage and repair during cholestasis

Cited by 4 publications

References 91 publications

In Vitro Models for Studying Chronic Drug-Induced Liver Injury

In Vitro Models for Studying Chronic Drug-Induced Liver Injury

Efecto protector del factor de crecimiento de hepatocitos (HGF) a nivel intestinal en un modelo murino de colestasis química inducida por α-Naftilisotiocianato (ANIT)

Recent Advances in Intrahepatic Biliary Epithelial Heterogeneity

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