“…Among all the herbs in BXD, Huanglian, Huangqin and Ganjiang can inhibit HP [ 44 – 48 ]. Besides, berberine, a natural isoquinoline alkaloid from Huanglian, possesses therapeutic effects on H. pylori-induced chronic atrophic gastritis [ 49 ]. Gancao can reduce injuries of GM [ 50 ].…”
Background
Banxia Xiexin decoction (BXD), a classical formula of traditional Chinese medicine (TCM), has been wildly used for chronic atrophic gastritis (CAG) patients with the cold-heat complex syndrome in China, and achieved satisfied effects. However, the clinical effects of it remains unclear.
Purpose
The purpose of this article is to evaluate the clinical efficacy and safety of BXD for CAG treatment.
Methods
We searched seven electronic databases including Ovid, Embase, PubMed, Cochrane Library, Wan-fang database, VIP (Chinese Scientific Journals Database) and CNKI (China National Knowledge Infrastructure) from their inception to September 21, 2020. We used Jadad scale and Cochrane Collaboration’s risk of bias tool to make evaluation of methodological quality. Revman 5.3 statistical software was used for statistical processing to evaluate the clinical efficacy and safety of BXD.
Results
26 randomized controlled trials (RCTs) totaling 1985 patients were identified for analysis. Meta-analysis showed that BXD treatment was more effective (RR 1.29; 95%CI 1.24, 1.35; P<0.00001) and safe (MD 0.33; 95%CI 0.18, 0.58; P = 0.0002) than Chinese patent medicine + western medicine. Furthermore, BXD had improvement on symptoms scores such as stomach distending pain, and belching. Besides, BXD was more effective in inhibiting Helicobacter Pylori (HP), improving HP-related inflammation, and relieving the degree of glandular atrophy, intestinal metaplasia (IM), and dysplasia of gastric mucosa (GM).
Conclusions
The meta-analysis showed that BXD was more effective and safer for CAG patients than the control group. However, due to limitations of methodological quality and small sample size of the included studies, further standardized research of rigorous design should be needed.
“…Among all the herbs in BXD, Huanglian, Huangqin and Ganjiang can inhibit HP [ 44 – 48 ]. Besides, berberine, a natural isoquinoline alkaloid from Huanglian, possesses therapeutic effects on H. pylori-induced chronic atrophic gastritis [ 49 ]. Gancao can reduce injuries of GM [ 50 ].…”
Background
Banxia Xiexin decoction (BXD), a classical formula of traditional Chinese medicine (TCM), has been wildly used for chronic atrophic gastritis (CAG) patients with the cold-heat complex syndrome in China, and achieved satisfied effects. However, the clinical effects of it remains unclear.
Purpose
The purpose of this article is to evaluate the clinical efficacy and safety of BXD for CAG treatment.
Methods
We searched seven electronic databases including Ovid, Embase, PubMed, Cochrane Library, Wan-fang database, VIP (Chinese Scientific Journals Database) and CNKI (China National Knowledge Infrastructure) from their inception to September 21, 2020. We used Jadad scale and Cochrane Collaboration’s risk of bias tool to make evaluation of methodological quality. Revman 5.3 statistical software was used for statistical processing to evaluate the clinical efficacy and safety of BXD.
Results
26 randomized controlled trials (RCTs) totaling 1985 patients were identified for analysis. Meta-analysis showed that BXD treatment was more effective (RR 1.29; 95%CI 1.24, 1.35; P<0.00001) and safe (MD 0.33; 95%CI 0.18, 0.58; P = 0.0002) than Chinese patent medicine + western medicine. Furthermore, BXD had improvement on symptoms scores such as stomach distending pain, and belching. Besides, BXD was more effective in inhibiting Helicobacter Pylori (HP), improving HP-related inflammation, and relieving the degree of glandular atrophy, intestinal metaplasia (IM), and dysplasia of gastric mucosa (GM).
Conclusions
The meta-analysis showed that BXD was more effective and safer for CAG patients than the control group. However, due to limitations of methodological quality and small sample size of the included studies, further standardized research of rigorous design should be needed.
“…The procedures of WB were performed as previously described by Yang et al (2020). Details on main antibodies are as follows: rabbit anti-CCNB1 Ab (Proteintech, Cat No.…”
Aims: The biological functions of cyclin B1 (CCNB1) in colon adenocarcinoma (COAD) will be explored in this study. Furthermore, the therapeutic effects and potential molecular mechanisms of ursolic acid (UA) in COAD cells will also be investigated in vitro.Methods: COAD data were obtained from Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases. Differentially expressed genes (DEGs) were determined with differential analysis. The biological functions of CCNB1 were analyzed through the GeneCards, the Search Tool for the Retrieval of Interacting Genes (STRING), and the Database for Annotation, Visualization, and Integrated Discovery (DAVID) databases. Therapeutic effects of UA on COAD cell lines HCT-116 and SW-480 were analyzed by CCK-8 and high-content screening (HCS) imaging assay. Flow cytometry was utilized to detect cell cycle changes of SW-480 and HCT-116 cells. Levels of mRNA and expression proteins of HCT-116, SW-480, and normal colon epithelial cells NCM-460 were determined by qRT-PCR and western blot.Results: CCNB1 was highly expressed and acted as an oncogene in COAD patients. CCNB1 and its interacting genes were significantly enriched in the cell cycle pathway. UA effectively inhibited the proliferation and injured COAD cells. In addition, UA arrested cell cycle of COAD cells in S phase. With regard to the molecular mechanisms of UA, we demonstrated that UA can significantly downregulate CCNB1 and its interacting genes and proteins, including CDK1, CDC20, CCND1, and CCNA2, which contributed to cell cycle blocking and COAD treatment.Conclusion: Results from this study revealed that UA possesses therapeutic effects on COAD. The anti-COAD activities of UA are tightly related to suppression of CCNB1 and its interacting targets, which is crucial in abnormal cell cycle process.
“…In addition, proinflammatory genes and interferon regulatory factor 8 (IRF8)‐interferon (IFN)‐γ signaling axis‐related genes, including Ifit3, Upp1, USP18, and Nlrc5, were suppressed by berberine administration in vitro and in vivo. The proteins expression related to IRF8‐IFN‐γ signaling axis, including Ifit3, IRF1, and Ifit1 were downregulated by berberine intervention 46 . Other studies have determined that berberine has anti‐inflammatory effects on H .…”
Section: Herb Medicines and Their Active Ingredient For The Therapy Of Helicobacter Pylori Infectionmentioning
confidence: 90%
“…The proteins expression related to IRF8-IFNγ signaling axis, including Ifit3, IRF1, and Ifit1 were downregulated by berberine intervention. 46 Other studies have determined that berberine has anti-inflammatory effects on H. pylori-induced chronic gastritis by attenuating the B cell-activating factor (BAFF)-triggered T helper cell 17 (Th17) response 67 and activating IL-4-signal transducers and activators of and berberine-loaded fucose-conjugated nanoparticles 71 were developed to localize berberine at the site of H. pylori infection and control the release of berberine, respectively, which significantly increased the suppressive effect of berberine on H. pylori growth.…”
Section: Berberine Is the Most Predominant Protoberberine Alkaloid Ofmentioning
Background
Helicobacter pylori–associated gastritis (HPAG) is a common digestive system disease that its therapeutic goal is to eradicate Helicobacter pylori. However, due to the widespread use of antibiotics, problems for example, antibiotic resistance, reinfection, and gastrointestinal side effects have emerged. The solution of above problems provides a broad space for traditional Chinese medicine (TCM) to exert its remarkable advantages on the treatment of HPAG.
Methods
Extensive database retrieval using platforms not limited to but including Web of Science, SpringerLink, ScienceDirect, Google Scholar, China National Knowledge Infrastructure, Wanfang, and VIP database was performed using keywords such as “Helicobacter pylori‐associated gastritis” or “HPAG” or “Helicobacter pylori” or “H. pylori” or “gastritis” and “traditional Chinese medicine” or “TCM” or “herbs” or “Chinese herbal medicine”. In addition, related books, PhD, and master's dissertations were also researched to provide a comprehensive review.
Results
This review mainly introduces the clinical efficacy of TCM formulas for HPAG, as well as active ingredient and pharmacological mechanisms of herbs. What's more, this review puts forward potential prospects for future research.
Conclusion
These research works have shown the therapeutic benefits of TCM in the treatment of HPAG. The development of TCM with more specific functions and practical data will not only become a significant trend in the world market but also have an irreplaceable role in the future treatment of HPAG. More continued researches should be undertaken in the future.
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