An overview of traditional Chinese medicine therapy for <i>Helicobacter pylori</i><i>–</i>related gastritis

Li, Yuli; Li, Xiaoya; Tan, Zhoujin

doi:10.1111/hel.12799

Cited by 25 publications

(29 citation statements)

References 30 publications

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“…New treatment strategies, including complementary and alternative medicine, are also being considered. Phytomedicines such as traditional Chinese medicine (TCM) treatment can not only improve the eradication rate of H. pylori , but also alleviate clinical symptoms and reduce adverse effects ( 128 ). H. pylori is considered as an “evil qi” in TCM theory.…”

Section: Treatmentmentioning

confidence: 99%

Helicobacter pylori Infection in Geriatric Patients: Current Situation and Treatment Regimens

et al. 2021

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Helicobacter pylori (H. pylori) has so far infected more than half the global population. It is the most important and controllable risk factor for gastric cancer. The elderly, who are at a higher incidence of the infection, are also commonly found to develop antibiotic resistance. The symptoms, diagnosis, clinical features (of gastric or extra-digestive diseases), and treatment of H. pylori infection in the elderly, are different from that in the non-elderly. Health conditions, including comorbidities and combined medication have limited the use of regular therapies in elderly patients. However, they can still benefit from eradication therapy, thus preventing gastric mucosal lesions and gastric cancer. In addition, new approaches, such as dual therapy and complementary therapy, have the potential to treat older patients with H. pylori infection.

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Section: Treatmentmentioning

confidence: 99%

Helicobacter pylori Infection in Geriatric Patients: Current Situation and Treatment Regimens

et al. 2021

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“…Furthermore, since eradication therapy with antibiotics and proton pump inhibitors can lead to serious adverse effects and/or long-term dysbiotic changes in the GI microbiota, the supplementation of probiotics[ 58 - 61 ], prebiotics, and microbial metabolites ( e.g., butyrate + inulin)[ 62 ] to reduce the negative effects of eradication should be considered[ 7 ]. In addition, alternative eradication regimens with limited or no antibiotic use, for example phage-based regimens[ 63 ], autoprobiotics[ 64 ], and natural agents and methods including traditional Chinese medicine[ 65 ], should be proposed, developed, and explored in future studies.…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal microbiome and Helicobacter pylori: Eradicate, leave it as it is, or take a personalized benefit–risk approach?

Ситкин¹,

Лазебник²,

Авалуева³

et al. 2022

WJG

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Helicobacter pylori ( H. pylori ) is generally regarded as a human pathogen and a class 1 carcinogen, etiologically related to gastric and duodenal ulcers, gastric cancer, and mucosa-associated lymphoid tissue lymphoma. However, H. pylori can also be regarded as a commensal symbiont. Unlike other pathogenic/ opportunistic bacteria, H. pylori colonization in infancy is facilitated by T helper type 2 immunity and leads to the development of immune tolerance. Fucosylated gastric mucin glycans, which are an important part of the innate and adaptive immune system, mediate the adhesion of H. pylori to the surface of the gastric epithelium, contributing to successful colonization. H. pylori may have beneficial effects on the host by regulating gastrointestinal (GI) microbiota and protecting against some allergic and autoimmune disorders and inflammatory bowel disease. The potential protective role against inflammatory bowel disease may be related to both modulation of the gut microbiota and the immunomodulatory properties of H. pylori . The inverse association between H. pylori and some potentially proinflammatory and/or procarcinogenic bacteria may suggest it regulates the GI microbiota. Eradication of H. pylori can cause various adverse effects and alter the GI microbiota, leading to short-term or long-term dysbiosis. Overall, studies have shown that gastric Actinobacteria decrease after H. pylori eradication, Proteobacteria increase during short-term follow-up and then return to baseline levels, and Enterobacteriaceae and Enterococcus increase in the short-term and interim follow-up. Various gastric mucosal bacteria ( Actinomyces , Granulicatella , Parvimonas , Peptostreptococcus , Prevotella , Rothia , Streptococcus, Rhodococcus , and Lactobacillus ) may contribute to precancerous gastric lesions and cancer itself after H. pylori eradication. H. pylori eradication can also lead to dysbiosis of the gut microbiota, with increased Proteobacteria and decreased Bacteroidetes and Actinobacteria. The increase in gut Proteobacteria may contribute to adverse effects during and after eradication. The decrease in Actinobacteria, which are pivotal in the maintenance of gut homeostasis, can persist for > 6 mo after H. pylori eradication. Furthermore, H. pylori eradication can alter the metabolism of gastric and intestinal bacteria. Given the available data, eradication cannot be an unconditional recommendation in every case of H. pylori infection, and the decision to eradicate H....

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“…Traditional Chinese medicine (TCM) has shown remarkable effects in the treatment of diseases [ 1 – 3 ] and has attracted increasing scientific attention worldwide. At present, more than 11 000 species of medicinal plants have been recorded in various TCM-related pharmacopoeias [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

TCMPG: an integrative database for traditional Chinese medicine plant genomes

Meng

Tang

Chu

et al. 2022

Horticulture Research

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Because of their great therapeutic and economic value, medicinal plants have attracted increasing scientific attention. With the rapid development of high-throughput sequencing technology, the genomes of many medicinal plants have been sequenced. Storing and analyzing the increasing volume of genomic data has become an urgent task. To solve this challenge, we have proposed the Traditional Chinese Medicine Plant Genome database (TCMPG, http://cbcb.cdutcm.edu.cn/TCMPG/), an integrative database for storing the scattered genomes of medicinal plants. TCMPG currently includes 160 medicinal plants, 195 corresponding genomes, and 255 herbal medicines. Detailed information on plant species, genomes, and herbal medicines is also integrated into TCMPG. Popular genomic analysis tools are embedded in TCMPG to facilitate the systematic analysis of medicinal plants. These include BLAST for identifying orthologs from different plants, SSR Finder for identifying simple sequence repeats, JBrowse for browsing genomes, Synteny Viewer for displaying syntenic blocks between two genomes, and HmmSearch for identifying protein domains. TCMPG will be continuously updated by integrating new data and tools for comparative and functional genomic analysis.

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An overview of traditional Chinese medicine therapy for Helicobacter pylori–related gastritis

Cited by 25 publications

References 30 publications

Helicobacter pylori Infection in Geriatric Patients: Current Situation and Treatment Regimens

Helicobacter pylori Infection in Geriatric Patients: Current Situation and Treatment Regimens

Gastrointestinal microbiome and Helicobacter pylori: Eradicate, leave it as it is, or take a personalized benefit–risk approach?

TCMPG: an integrative database for traditional Chinese medicine plant genomes

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