Mechanism of anti-inflammatory effect of tricin, a flavonoid isolated from Njavara rice bran in LPS induced hPBMCs and carrageenan induced rats

Shalini, V.; Jayalekshmi, Ananthasankaran; Helen, A.

doi:10.1016/j.molimm.2015.03.004

Cited by 33 publications

(21 citation statements)

References 55 publications

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“…Tricin was tentatively identified and observed in all samples ( t R = 42.907 min) with an m / z of 329 [M‐H] − and fragment ions of m / z 139, 171, 211, and 287 which corresponds to the molecular ion of tricin as reported by Poulev, Heckman, Raskin, and Belanger () in the positive ion. A study conducted by Shalini, Jayalekshmi, and Helen () has reported that tricin, a bioflavonoid from medicinal rice variety Njavara, can be considered to be a powerful anti‐inflammatory agent against carrageenan‐induced paw edema.…”

Section: Resultsmentioning

confidence: 99%

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Stabilization treatment of rice bran alters phenolic content and antioxidant activity

et al. 2020

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Background and objectives Rice bran (RB), a by‐product of the rice milling process, is known to be a rich source of bioactive phytochemicals. This study aimed to evaluate the influence of RB stabilization treatments, usually applied to inhibit rancidification, on its phenolic composition and antioxidant activity. Findings Total phenolic content (TPC) and antioxidant assays were performed on RB that was exposed to extrusion, drum‐drying, microwave, and oven stabilization treatments. Chemical profiling was conducted using ultra‐high performance liquid chromatography (uHPLC) coupled to an online ABTS system, and liquid chromatography quadrupole time‐of‐flight mass spectrometry (LC‐QTOF‐MS). Extrusion and drum‐dried stabilization significantly increased TPC when compared to non‐stabilized RB (NS‐RB). All stabilization treatments increased antioxidant capacity and radical scavenging activity. uHPLC/online ABTS and LC‐QTOF‐MS identified all treatments to increase the concentration of free phenolic compounds and antioxidant activity compared to NS‐RB. More specifically, drum‐dried RB significantly altered RB phenolic composition when compared to all other treatments. Conclusions All stabilization treatments significantly altered TPC and antioxidant activity of RB. Drum‐dried RB treatment was most effective in improving free phenolic composition and antioxidant activity. Significance and novelty This study demonstrated that drum‐dried stabilization treatment may be a crucial technique that can be applied to RB to ensure essential phenolic compounds with antioxidant activity remain intact, thereby adding value to the functional and nutritional quality of RB.

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Section: Resultsmentioning

confidence: 99%

“…Poulev, Heckman, Raskin, and Belanger (2019) in the positive ion. A study conducted by Shalini, Jayalekshmi, and Helen (2015) has reported that tricin, a bioflavonoid from medicinal rice variety Njavara, can be considered to be a powerful anti-inflammatory agent against carrageenaninduced paw edema.…”

Section: Bound Phenolic Compoundsmentioning

confidence: 99%

Stabilization treatment of rice bran alters phenolic content and antioxidant activity

et al. 2020

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“…In addition, the molecular mechanisms for its biological effects were partly identified. Tricin reduced inflammatory responses in human peripheral blood mononuclear cells (hPBMCs) by regulating the TLR4/NF-κB/STAT, p38MAPK and PI3K/AKT pathways (28,29). It has been also found that tricin exhibits potent anticancer effects in various cancer cells including breast and colon cancers via the inhibition of cyclooxygenase and P-glycoprotein activities (30,31).…”

Section: Discussionmentioning

confidence: 99%

Tricin, 4′,5,7-trihydroxy-3′,5′-dimethoxyflavone, exhibits potent antiangiogenic activity in vitro

Han

Kwon

Jung

2016

International Journal of Oncology

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Tumor growth and metastasis depend on angiogenesis triggered by chemical signals, such as vascular endothelial growth factor (VEGF), released from tumor cells. Therefore, the specific perturbation of angiogenesis has been considered a powerful strategy for the treatment of cancer. Herein, we report that tricin, 4',5,7-trihydroxy-3',5'-dimethoxyflavone, exhibits potent antiangiogenic activity in vitro. Tricin effectively suppressed the proliferation as well as VEGF-induced invasion and tube formation of human umbilical vein endothelial cells (HUVECs) at subtoxic doses. Furthermore, tricin significantly inhibited the angiogenesis of the chorioallantoic membrane from growing chick embryos without showing cytotoxicity. We also found that tricin blocked tumor cell-induced angiogenesis. Notably, tricin downregulated not only the VEGFR2 signal transduction by reducing reactive oxygen species (ROS) generation in endothelial cells, but also the expression of VEGF by inhibiting hypoxia inducible factor-1α (HIF-1α) accumulation in tumor cells. Moreover, combined treatment with tricin and bevacizumab, an anti-VEGF drug, ameliorated the antiangiogenic effect of bevacizumab. Taken together, our findings demonstrate for the first time that tricin possesses promising antiangiogenic potential and thus may be applied to anticancer therapy by targeting tumor angiogenesis.

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“…Molecular mechanism of anti-inflammatory activity of tricin effect on NF-κB is signaling and pro-inflammatory genes expression using the lipo-polysaccharide (LPS) that induced human peripheral blood mononuclear cell. 6 Tricin is a multifunctional nutraceutical due to the beneficial health effects such as antioxidant effect through oxidative degradation of lipid and sparing effect on vitamin E in erythrocyte membrane. …”

Section: Tricin Flavonoidmentioning

confidence: 99%

Flavonoids in Rice, Their Role in Health Benefits

Nk¹

2017

MOJFPT

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Rice is a staple food for more than 60% of world population and it's the world's most consumed cereal. The rice grains contain many bioactive components as one of the major content which are the group of substances with beneficial health properties that are produced as secondary metabolites during grain filling. In rice flavonoids include tricin, luteolin, apigenin, quercetin, isorhamnetin, kaempferol and myricetin have human health benefits. This compound possesses many properties such as antioxidant, anticancer, antiinflammation, cholesterol lowering activity and also illustrates prevention of human diseases like cancer and cardiovascular diseases. Bioactive compounds and flavonoids show different mode of actions includes, direct radical scavenging activity, cell membrane interaction, interacting with the protein of signaling pathways, inhibition of cell proliferation, platelet aggregation, cholesterol oxidation, natural killer cell and macrophage activation and inhibition of angiogenesis.

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Mechanism of anti-inflammatory effect of tricin, a flavonoid isolated from Njavara rice bran in LPS induced hPBMCs and carrageenan induced rats

Cited by 33 publications

References 55 publications

Stabilization treatment of rice bran alters phenolic content and antioxidant activity

Stabilization treatment of rice bran alters phenolic content and antioxidant activity

Tricin, 4′,5,7-trihydroxy-3′,5′-dimethoxyflavone, exhibits potent antiangiogenic activity in vitro

Flavonoids in Rice, Their Role in Health Benefits

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