Mechanism of Alteration in Baroreflex Cardiovascular Responses due to Volume Loading

Chen, Hsing I.

doi:10.2170/jjphysiol.28.749

Cited by 5 publications

(4 citation statements)

References 17 publications

(23 reference statements)

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“…As the typical example of the Homeostasis in the textbook of every medical school, students must learn the Baroreflex system (12)(13)(14)(15)(16). When the blood pressure was increased, baroreceptors in the carotid arteries and aortic arch sensed the increase of the baroreflex system.…”

Section: Diagnosis Of the Baroreflex Sensitivity Of An Arterymentioning

confidence: 99%

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Development of new quantitative diagnosis machine to evaluate the Baroreflex sensitivity of an artery for patients with hypertension

Yambe

Sugita

Yoshizawa

2009

2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Text book in all medical school showed that the baroreflex system is one of the most important regulatory systems. When blood pressure increases, heart rate decrease and an artery is dilated with the baroreflex system. By decrease of cardiac output and arterial resistances, blood pressure returns to the normal value. However, there is no diagnostic method, which can measure the sensitivity of a baroreflex system of the artery by the simple methodology. We had challenged invention of the new machine, which could diagnose the sensitivity of the baroreflex system of not only a heart, but also an artery. In this system, the measurement sections are only an electrocardiography (ECG) and peripheral pulse wave. These time series is inputted into a personal computer system, and analyzed quantitatively. Responses of the artery were measured with pulse wave velocity (PWV) calculated from pulse wave transmission time from heart to an artery. In this system, the heart rate change corresponding to the blood-pressure change in time series sequence is observed. Delay time was measured by the cross correlation function. Slope of the blood pressure (BP) change and heart rate (HR) change showed the sensitivity of the baroreflex system of heart. Furthermore, this system can measure the sensitivity of the baroreflex system of an artery. Change of PWV in response to the BP change was observed. We found that significant correlation was observed in the time sequence between BP change and PWV change after delay time calculated from cross correlation. Clinical research was started through allowance of the Ethics Committee. Decreased sensibility in the hypertensive patient's baroreflex system was observed as a result of the clinical research. Furthermore, alteration of the baroreflex sensitivity before and after the drug administration was evaluated. For example, Azelnidipine, Calcium antagonists improved the baroreflex sensitivity of the artery in several cases. This system may be useful f- or the follow up of the hypertensive patients.

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Section: Diagnosis Of the Baroreflex Sensitivity Of An Arterymentioning

confidence: 99%

“…When blood pressure increases, heart rate decrease and an artery is dilated with the baroreflex system in the normal human body (12,13). By decrease of cardiac output and peripheral arterial resistances, blood pressure returns to the normal value.…”

Section: Introductionmentioning

confidence: 99%

Development of new quantitative diagnosis machine to evaluate the Baroreflex sensitivity of an artery for patients with hypertension

Yambe

Sugita

Yoshizawa

2009

2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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“…The baroreflex system is a key indicator of hypertensive pathophysiology (1)(2)(3)(4). When blood pressure (BP) increases, heart rate (HR) decreases, and there is peripheral arterial dilation (1-6).…”

mentioning

confidence: 99%

Baroreflex Sensitivity of an Arterial Wall During Rotary Blood Pump Assistance

et al. 2009

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It is well known that the baroreflex system is one of the most important indicators of the pathophysiology in hypertensive patients. We can check the sensitivity of the baroreflex by observing heart rate (HR) responses; however, there is no simple diagnostic method to measure the arterial behavior in the baroreflex system. Presently, we report the development of a method and associated hardware that enables the diagnosis of baroreflex sensitivity by measuring the responses of both the heart and the artery. In this system, the measurements are obtained by monitoring an electrocardiogram and a pulse wave recorded from the radial artery or fingertip. The arterial responses were measured in terms of the pulse wave velocity (PWV) calculated from the pulse wave transmission time (PTT) from the heart to the artery. In this system, the HR change corresponding to the blood pressure change in time series sequence was observed. Slope of the changes in blood pressure and HR indicated the sensitivity of the baroreflex system of the heart. This system could also measure the sensitivity of the baroreflex system of an artery. Changes in the PWV in response to the blood pressure changes were observed. Significant correlation was observed in the time sequence between blood pressure change and PWV change after calculating the delay time by cross-correlation. The slope of these parameter changes was easily obtained and it demonstrated the sensitivity of the baroreflex system of an artery. We evaluated this method in animal experiments using rotary blood pump (RBP) with undulation pump ventricular assist device, and PTT elongation was observed in response to increased blood pressure with RBP assistance. Furthermore, when tested clinically, decreased sensitivity of the baroreflex system in hypertensive patients was observed. This system may be useful when we consider the ideal treatment and follow-up of patients with hypertension.

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“…Infusion rate or total percentage of body weight infused was not always specified (8,11,12,14). Urine production, blood gases, and hematocrit were usually not mentioned ( 5 , 7,8,11,15,16), yet these variables could indicate changes in total body fluid, compartmental fluid shifts, and chemoreceptor stimulation. Clearly, unspecified differences in experimental conditions could account for differences in conclusions regarding the role of the nervous system in response to acute volume expansion.…”

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confidence: 99%

Control of Hemodynamic Adjustments during Acute Volume Expansion in the Rabbit

Taylor

Peterson

1984

Experimental Biology and Medicine

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The influence of reflexes mediated by the carotid sinus, aortic, and vagus nerves on control of blood pressure were investigated in the pentobarbital-anesthetized rabbit during an acute intravascular volume expansion. Blood, kept at 37"C, was gradually infused at 2.5-min intervals until the blood volume of each animal was expanded to 10, 20, 30, and 40% above normal. Responses in sinoaortic-vagally denervated rabbits were compared to intact rabbits. Both intact and denervated animals showed a significant increase in central venous pressure with each 10% addition of blood. Heart rate did fall significantly in the intact group but not in the denervated group. No significant changes were identified in mean arterial pressure (MAP) in either group. In both groups changes in cardiac output were significantly greater than control for 20, 30, and 40% expansion and calculated total peripheral resistance fell in both groups at all levels of expansion when compared to control. The absence of significant changes in MAP within the intact and denervated groups suggests that sinoaortic-vagal reflexes are not affecting control of MAP in response to slow, acute volume expansion in the intact rabbit. On the other hand, since total peripheral resistance fell in both groups, a non-sinoaortic-vagal mechanism appears to be functional. This mechanism may assist in increasing vascular capacitance in order to prevent significant increases in blood pressure. 366

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Mechanism of Alteration in Baroreflex Cardiovascular Responses due to Volume Loading

Cited by 5 publications

References 17 publications

Development of new quantitative diagnosis machine to evaluate the Baroreflex sensitivity of an artery for patients with hypertension

Development of new quantitative diagnosis machine to evaluate the Baroreflex sensitivity of an artery for patients with hypertension

Baroreflex Sensitivity of an Arterial Wall During Rotary Blood Pump Assistance

Control of Hemodynamic Adjustments during Acute Volume Expansion in the Rabbit

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