Mechanism of action of vitamin K

Abstract

We have discovered a novel, spontaneous model oxidation that leads to a powerful base capable of carrying out a carbon-carbon bond forming condensation reaction analogous to that observed in the vitamin K-mediated carboxylation of glutamate. The model sequence incorporates a novel base-strength enhancement sequence and it implicates molecular oxygen as the initiating factor in the vitamin K-dependent carboxylation. When the oxygenation is carried out under an atmosphere of (18)O2, two atoms of (18)O are incorporated into the vitamin K oxide product. Selective (18)O labelling defines the carbonyl group next to methyl as the active site of the vitamin K.

Plausible ergogenic effects of vitamin D on athletic performance and recovery

“…Both forms play different roles in the body [ 117 ], but the IOM has set the recommended dietary intake only for the K 1 isoform (90 mcg/day for women and 120 mcg/day for men), with no upper limit, and has yet to set any dietary recommendation for vitamin K 2 [ 114 ]. Specifically, vitamin K 1 has a key role in the carboxylation of various blood clotting proteins, where vitamin K 2 is essential for the carboxylation and activation of osteocalcin and matrix Gla protein (MGP) (an essential protein needed to prevent soft tissue calcification) [ 118 ].…”

Alimentos funcionais na prevenção da doença periodontal

“…Os processos fisiológicos do organismo e dos tecidos periodontais necessitam de suprimento adequado para acontecer. A vitamina K, por exemplo, é conhecida como vitamina anti-hemorrágica, devido ao fato de que a formação do coágulo depende dessa vitamina, além de participar na manutenção dos ossos, como o osso alveolar (Acevedo et al, 2001;Dowd et al, 1994). A maioria dos alimentos ricos em vitamina K são alimentos funcionais, podendo citar espinafre, agrião, brócolis e couve.…”

A Unified Approach for the Total Synthesis of cyclo‐Archaeol, iso‐Caldarchaeol, Caldarchaeol, and Mycoketide

“…Long-chain syn-1,5 methyl-branched lipids are biologically highly relevant compounds from either isoprenoid or polyketide origin. Thea rchitecture is found in ar ange of natural products such as tocopherols (vitamin E), [1] aplethora of insect pheromones, [2] lipids [3] and ketides [7] (Figure 1). Archaeal membrane phospholipids,a re produced via an isoprenoid pathway.A rchaea are able to thrive under harsh conditions such as high salinity,a cidity and temperature and the methyl-branched lipids are essential for membrane fluidity and decreased ion permeability.…”