Mechanism of Action of Nitrogen Pressure in Controlling Striatal Dopamine Level of Freely Moving Rats is Changed by Recurrent Exposures to Nitrogen Narcosis

Lavoûte, Cécile; Weiss, Michel; Risso, Jean-Jacques; Rostain, Jean-Claude

doi:10.1007/s11064-011-0657-1

Cited by 7 publications

(11 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It can be speculated that for SCUBA divers, the repetitive unpredictable activation of different neuronal receptors and changes in neurotransmitters levels may lead to adaptation of neuronal function, commonly known as plasticity. This may be further supported by the fact that repeated exposures to nitrogen high partial pressures have neurotoxic effects in rats (Lavoute et al., ).…”

Section: Discussionmentioning

confidence: 92%

Long term effects of recreational SCUBA diving on higher cognitive function

Hemelryck

Germonpré

Papadopoulou

et al. 2013

Scandinavian Med Sci Sports

View full text Add to dashboard Cite

We investigated long-term effects of SCUBA diving on cognitive function using a battery of neuropsychometric tests: the Simple Reaction Time (REA), Symbol Digit Substitution (SDS), Digit Span Backwards (DSB), and Hand-Eye Coordination tests (EYE). A group (n = 44) of experienced SCUBA divers with no history of decompression sickness was compared to non-diving control subjects (n = 37), as well as to professional boxers (n = 24), who are considered at higher risk of long term neurological damage. The REA was significantly shorter in SCUBA divers compared to the control subjects, and also more stable over the time course of the test. In contrast, the number of digits correctly memorized and reordered (DSB) was significantly lower for SCUBA divers compared to the control group. The results also showed that boxers performed significantly worse than the control group in three out of four tests (REA, DSB, EYE). While it may be concluded that accident-free SCUBA diving may have some long-term adverse effects on short-term memory, there is however, no evidence of general higher cognitive function deficiency.

show abstract

Section: Discussionmentioning

confidence: 92%

Long term effects of recreational SCUBA diving on higher cognitive function

Hemelryck

Germonpré

Papadopoulou

et al. 2013

Scandinavian Med Sci Sports

View full text Add to dashboard Cite

show abstract

“…Moreover, Lavoute et al (66), exposed to nitrogen at a total pressure of 31 ATA, these rats that presented a long lasting decrease activity in striatal DA neurotransmission. The rats exhibited alterations of NMDA receptor activity, the desensitization of GABA A receptors on dopaminergic cells and the sensitization of GABA A receptors on GABA interneurons of the SNc (Table 6), altogether inducing an increase in striatal DA release (Fig.…”

Section: Neurochemical Datamentioning

confidence: 97%

“…The possible neurotoxicity due to repetitive exposure to nitrogen at high pressures has been studied by examining the activities of the NMDA and GABA A receptors in excitatory and inhibitory neurotransmission of the nigrostriatal pathway (66,70,71). The administration of NMDA and GABA A agonists or antagonists into the SNc showed that repetitive exposure of rats to high-pressure nitrogen decreased the activity of the dopaminergic pathway, reflecting increased GABAergic neurotransmission linked to the alteration of GABA A receptors.…”

Section: Neurochemical Datamentioning

confidence: 99%

“…Findings for the effects of repetitive exposure to nitrogen at high pressure are such that further studies are required to investigate the mechanisms involved in the neurochemical changes of these regulatory processes. It would be informative to determine whether these mechanisms are the consequence of nitrogen neurotoxicity or nitrogen addiction induced by repeated exposure (66).…”

Section: Neurochemical Datamentioning

confidence: 99%

See 1 more Smart Citation

Neurochemistry of Pressure‐Induced Nitrogen and Metabolically Inert Gas Narcosis in the Central Nervous System

Rostain

Lavoûte

2016

Comprehensive Physiology

Self Cite

View full text Add to dashboard Cite

Gases that are not metabolized by the organism are thus chemically inactive under normal conditions. Such gases include the "noble gases" of the Periodic Table as well as hydrogen and nitrogen. At increasing pressure, nitrogen induces narcosis at 4 absolute atmospheres (ATAs) and more in humans and at 11 ATA and more in rats. Electrophysiological and neuropharmacological studies suggest that the striatum is a target of nitrogen narcosis. Glutamate and dopamine release from the striatum in rats are decreased by exposure to nitrogen at a pressure of 31 ATA (75% of the anesthetic threshold). Striatal dopamine levels decrease during exposure to compressed argon, an inert gas more narcotic than nitrogen, or to nitrous oxide, an anesthetic gas. Inversely, striatal dopamine levels increase during exposure to compressed helium, an inert gas with a very low narcotic potency. Exposure to nitrogen at high pressure does not change N-methyl-d-aspartate (NMDA) glutamate receptor activities in Substantia Nigra compacta and striatum but enhances gama amino butyric acidA (GABAA) receptor activities in Substantia Nigra compacta. The decrease in striatal dopamine levels in response to hyperbaric nitrogen exposure is suppressed by recurrent exposure to nitrogen narcosis, and dopamine levels increase after four or five exposures. This change, the lack of improvement of motor disturbances, the desensitization of GABAA receptors on dopamine cells during recurrent exposures and the long-lasting decrease of glutamate coupled with the higher sensitivity of NMDA receptors, suggest a nitrogen toxicity induced by repetitive exposures to narcosis. These differential changes in different neurotransmitter receptors would support the binding protein theory. © 2016 American Physiological Society. Compr Physiol 6:1579-1590, 2016.

show abstract

“…conditions [8]. However, motor deficiencies were not improved following the increase in dopamine levels, suggesting neurotoxicity or addiction effects.…”

Section: Discussionmentioning

confidence: 94%

Dopamine-dependent biphasic behaviour under ‘deep diving’ conditions in Caenorhabditis elegans

et al. 2021

View full text Add to dashboard Cite

Underwater divers are susceptible to neurological risks due to their exposure to increased pressure. Absorption of elevated partial pressure of inert gases such as helium and nitrogen may lead to nitrogen narcosis. Although the symptoms of nitrogen narcosis are known, the molecular mechanisms underlying these symptoms have not been elucidated. Here, we examined the behaviour of the soil nematode Caenorhabditis elegans under scuba diving conditions. We analysed wild-type animals and mutants in the dopamine pathway under hyperbaric conditions, using several gas compositions and under varying pressure levels. We found that the animals changed their speed on a flat bacterial surface in response to pressure in a biphasic mode that depended on dopamine. Dopamine-deficient cat-2 mutant animals did not exhibit a biphasic response in high pressure, while the extracellular accumulation of dopamine in dat-1 mutant animals mildly influenced this response. Our data demonstrate that in C. elegans , similarly to mammalian systems, dopamine signalling is involved in the response to high pressure. This study establishes C. elegans as a powerful system to elucidate the molecular mechanisms that underly nitrogen toxicity in response to high pressure.

show abstract

Mechanism of Action of Nitrogen Pressure in Controlling Striatal Dopamine Level of Freely Moving Rats is Changed by Recurrent Exposures to Nitrogen Narcosis

Cited by 7 publications

References 38 publications

Long term effects of recreational SCUBA diving on higher cognitive function

Long term effects of recreational SCUBA diving on higher cognitive function

Neurochemistry of Pressure‐Induced Nitrogen and Metabolically Inert Gas Narcosis in the Central Nervous System

Dopamine-dependent biphasic behaviour under ‘deep diving’ conditions in Caenorhabditis elegans

Contact Info

Product

Resources

About