Mechanism of Action of Mesenchymal Stem Cell-Derived Exosomes in the Intervertebral Disc Degeneration Treatment and Bone Repair and Regeneration

Liang, Weishi; Han, Bo; Hai, Yong; Sun, Duan; Yin, Peng

doi:10.3389/fcell.2021.833840

Cited by 25 publications

(23 citation statements)

References 96 publications

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“…With the identification of the natural existence of stem/progenitor cells in degenerate intervertebral disc ( 114 ), possible approaches were conceived to overcome the endogenous repair failure in natural IDD process ( 77 , 101 , 116 , 115 ). In the most recent papers, therapies based on MSC-derived exosomes ( 116 , 117 , 118 ) or notochordal cells ( 119 , 120 ) were regarded as novel strategies for ameliorating IDD, with a relative preference for exosomes according to the number of articles.…”

Section: Discussionmentioning

confidence: 99%

Research trends and hotspots of mesenchymal stromal cells in intervertebral disc degeneration: a scientometric analysis

Yao

Wang

2023

EFORT Open Reviews

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Mesenchymal stromal cells (MSCs) are important potential candidates for regenerative therapy for intervertebral disc degeneration (IDD). This scientometric study aimed to summarize the main research trends, identify current research hotspots, and measure the networks of the contributors and their scientific productivity. A total of 1102 publications regarding MSC in IDD were recognized from January 2000 to April 2022. The number of records every year followed an overall uptrend with fluctuations. The main trend of research demonstrated the practice of gradually applying MSC-based therapy to IDD with the assistance of advances in biomaterials and IDD pathology. A recent focus on MSC-derived exosomes and notochordal cells was detected. The basic studies in this field were mainly contributed to by Japan, the USA, and European countries, while China dominated in the number of recent publications. Tokai University with Daisuke Sakai was the most productive contributor. Cell biology, tissue engineering, and biomaterials were the categories with deep engagement in research of this field.

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Section: Discussionmentioning

confidence: 99%

Research trends and hotspots of mesenchymal stromal cells in intervertebral disc degeneration: a scientometric analysis

Yao

Wang

2023

EFORT Open Reviews

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“…[112] A large amount of data suggests that MSC-EVs maintain ECM homeostasis by upregulating the expression of ECM-related molecules. [113] BM-MSC-derived exosomes carrying circ_0050205 promote NPC proliferation and produce a healthy ECM in degenerated NPCs. [114] Similarly, exosomes from adipose tissue-derived MSCs increased and decreased the expression of type II collagen and MMP-13, respectively, thereby promoting ECM formation in degenerative intervertebral discs.…”

Section: Intervertebral Disc Degenerationmentioning

confidence: 99%

Mesenchymal Stem Cells‐Derived Extracellular Vesicles in Orthopedic Diseases: Recent Advances and Therapeutic Potential

Wang,

Tian,

Yang

et al. 2023

Advanced Therapeutics

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Ever since the first application of mesenchymal stem cell (MSC) transplantation treating human hematologic malignancies in 1995, MSC‐based treatments have demonstrated great therapeutic potential in clinical settings. However, only a few MSC‐based cell therapy products have been clinically approved. Accumulating evidence suggests that the beneficial effects of MSCs are mainly attributed to the release of paracrine factors or extracellular vesicles (EVs) rather than their mesodermal differentiation potential. Therefore, MSC‐derived EVs, such as exosomes and microvesicles, have merged as promising alternatives to traditional cell‐based therapeutics in clinical practice. They offer several advantages such as better safety, lower immunogenicity, protection of cargoes from degradation, and the ability to overcome biological barriers. Moreover, there have been multiple clinical studies exploring the potential of MSC‐EVs for treating various diseases, including orthopedic disorders. However, there is no definitive “cure” for conditions such as osteoporosis and other bone disorders, but MSC‐EVs have displayed significant therapeutic potential for these orthopedic ailments. Therefore, the objective of this study is to conduct a systematic review of current knowledge related to MSC‐derived EVs (MSC‐EVs) and emphasize their potential application in treating orthopedic diseases, such as bone defects, osteoarthritis, osteoporosis, intervertebral disc degeneration, osteosarcoma and osteoradionecrosis.This article is protected by copyright. All rights reserved

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“…Further, they also contain various paracrine mediators, which are considered as a potential cell-free therapy for IVDD [57]. Exosomes derived from MSCs contain of a variety of regulatory factors that inhibit apoptosis, inhibit ECM degradation, downregulate inflammation, and promote chondrogenic differentiation, which could prevent IVDD [84] (Tables 1 and 2).…”

Section: Mesenchymal Stem Cell Therapy In Ivddmentioning

confidence: 99%

Mesenchymal Stem Cell-Derived Exosomes and Intervertebral Disc Regeneration: Review

Bhujel

Shin

Choi

et al. 2022

IJMS

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Intervertebral disc degeneration (IVDD) is a common cause of lower back pain (LBP), which burdens individuals and society as a whole. IVDD occurs as a result of aging, mechanical trauma, lifestyle factors, and certain genetic abnormalities, leads to loss of nucleus pulposus, alteration in the composition of the extracellular matrix, excessive oxidative stress, and inflammation in the intervertebral disc. Pharmacological and surgical interventions are considered a boon for the treatment of IVDD, but the effectiveness of those strategies is limited. Mesenchymal stem cells (MSCs) have recently emerged as a possible promising regenerative therapy for IVDD due to their paracrine effect, restoration of the degenerated cells, and capacity for differentiation into disc cells. Recent investigations have shown that the pleiotropic effect of MSCs is not related to differentiation capacity but is mediated by the secretion of soluble paracrine factors. Early studies have demonstrated that MSC-derived exosomes have therapeutic potential for treating IVDD by promoting cell proliferation, tissue regeneration, modulation of the inflammatory response, and reduced apoptosis. This paper highlights the current state of MSC-derived exosomes in the field of treatment of IVDD with further possible future developments, applications, and challenges.

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Mechanism of Action of Mesenchymal Stem Cell-Derived Exosomes in the Intervertebral Disc Degeneration Treatment and Bone Repair and Regeneration

Cited by 25 publications

References 96 publications

Research trends and hotspots of mesenchymal stromal cells in intervertebral disc degeneration: a scientometric analysis

Research trends and hotspots of mesenchymal stromal cells in intervertebral disc degeneration: a scientometric analysis

Mesenchymal Stem Cells‐Derived Extracellular Vesicles in Orthopedic Diseases: Recent Advances and Therapeutic Potential

Mesenchymal Stem Cell-Derived Exosomes and Intervertebral Disc Regeneration: Review

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