Mechanism of Action of Gonadotropins and Prolactin

Dorfman, Ralph I.

doi:10.1016/b978-0-12-452802-4.50015-9

Cited by 8 publications

(6 citation statements)

References 73 publications

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“…A superovulatory response did not occur with these preparations, unlike PMSG which has been shown to stimulate superovulation in hpg females (Ward, 1980). This may have been due to the relative purity of the FSH preparations used in these studies, since PMSG has a dual FSH/LH like activity (Ben-Or, 1970;Dorfman, 1972); however, superovulation was not produced by the combined injection of FSH and LH and therefore this phenomenon may, at least in part, reflect the longer half-life of PMSG (Ben-Or, 1972).…”

Section: Discussionmentioning

confidence: 91%

Effects of short-term injection of gonadotrophins on ovarian follicle development in hypogonadal (hpg) mice

Halpin¹,

Charlton²

1988

Reproduction

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Section: Discussionmentioning

confidence: 91%

Effects of short-term injection of gonadotrophins on ovarian follicle development in hypogonadal (hpg) mice

Halpin¹,

Charlton²

1988

Reproduction

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“…At the same time the testicular total, structural and soluble protein concentrations also decreased. Prolactin has a tendency to augment tissue weights and anabolic activities in tissues (Okamato et al 1967;Peyre et al 1968;Bartke & Lloyd 1970;Boyns et al 1972;Dorfman 1972;Farnsworth 1972;Horrobin 1973). The decreased testicular protein concentrations in the present study suggest unfavorable conditions for cell division and proliferation.…”

Section: Discussionmentioning

confidence: 52%

Effect of prolactin inhibition by bromocriptine on testicular metabolism in the adult rat

Rao¹,

Govindarajulu²

1982

Int J of Andrology

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Administration of bromocriptine resulted in a decrease of testicular tissue somatic index, total, structural and soluble protein concentrations. The catabolic phase of carbohydrate metabolism was enhanced. Consequently, the required metabolites for increased citric acid cycle activity were provided by increased glycolytic activity. The pre-requisite metabolites needed for spermatogenic processes were accumulated in the testis, due to their non-utilization. The results obtained suggest a specific influence of prolactin inhibition on testicular metabolism in the adult rat.

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“…Earlier studies have indicated that prolactin stimulates prostatic growth (Okamoto et al, 1967;Negro-Vilar et al, 1973) and increases the weight of the seminal vesicles (Chase et al, 1957;Antliff et al, 1960;Bengmark & Hesselsjo, 1963, 1964Dorfman, 1972;Negro-Vilar et al, 1973). These effects, however, were manifest only when prolactin was used with androgens.…”

mentioning

confidence: 94%

“…Several investigators have claimed that prolactin alone or synergistically with androgens has a role in the growth of the male accessory sex organs (Segaloff et al, 1956;Chase et al, 1957;Antliff et al, 1960;Bengmark & Hesselsjo, 1963, 1964Okamoto et al, 1967;Dorfman, 1972;Negro-Vilar et al, 1973). In these studies, large amounts of prolactin were used, and the possible presence of small amounts of contaminating LH could not be ruled out.…”

mentioning

confidence: 99%

Synergistic Action of Prolactin With HCG on Rat Ventral Prostate

Dattatreymurty¹,

Raghavan²,

Purandare³

et al. 1975

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The increase in the weights of the ventral prostate and other accessory sex organs of the immature rat has been employed as an end point for estimating the biological potency of preparations of LH and HCG (Greep et al., 1941(Greep et al., , 1942Diczfalusy & Loraine, 1955). Several investigators have claimed that prolactin alone or synergistically with androgens has a role in the growth of the male accessory sex organs (Segaloff et al., 1956;Chase et al., 1957;Antliff et al., 1960;Bengmark & Hesselsjo, 1963, 1964Okamoto et al., 1967;Dorfman, 1972;Negro-Vilar et al., 1973). In these studies, large amounts of prolactin were used, and the possible presence of small amounts of contaminating LH could not be ruled out. It was therefore of interest to re-examine the effects of prolactin alone or with HCG on the growth of the male accessory sex glands of the rat.Biological and bioimmunological experiments were carried out (see Table 1 ) with 20-to 23-day-old immature male rats of the Holtzman strain. The HCG (Ayerst Laboratories, U.S.A.) and ovine prolactin (NIH-P-S10) were administered subcutaneously to rats once a day on 3 consecutive days, at approximately 24-hr intervals while control animals received saline or normal rabbit serum. In the bioimmunological experiments, one group of animals received a mixture of ovine prolactin and the antiserum to ovine prolactin, which was incubated at 37\g=deg\C for 1\ m=1/ 2\ hr. The preparation and specificity of this antiserum has been described elsewhere Thakur et al., 1975

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Mechanism of Action of Gonadotropins and Prolactin

Cited by 8 publications

References 73 publications

Effects of short-term injection of gonadotrophins on ovarian follicle development in hypogonadal (hpg) mice

Effects of short-term injection of gonadotrophins on ovarian follicle development in hypogonadal (hpg) mice

Effect of prolactin inhibition by bromocriptine on testicular metabolism in the adult rat

Synergistic Action of Prolactin With HCG on Rat Ventral Prostate

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