Effect of prolactin inhibition by bromocriptine on testicular metabolism in the adult rat

Rao, M.; Govindarajulu, P.

doi:10.1111/j.1365-2605.1982.tb00262.x

Cited by 6 publications

(2 citation statements)

References 15 publications

(5 reference statements)

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“…Only five journals published no less than five articles. They were the Indian Journal of Experimental Biology (10 articles [13,14,15,16,17,18,19,20,21,22]), Biology of Reproduction (7 articles [23,24,25,26,27,28,29]), Journal of Reproduction and Fertility (6 articles [30,31,32,33,34,35]), Endocrinology (5 articles [10,36,37,38,39]), and International Journal of Andrology (5 articles [40,41,42,43,44]). A total of 26 journals (26.9%) published only 2–4 articles, and 66 journals (68.0%) published only one article.…”

Section: Resultsmentioning

confidence: 99%

Research Trends and Hotspots Analysis Related to the Effects of Xenobiotics on Glucose Metabolism in Male Testes

Fan

et al. 2018

IJERPH

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This study aimed to integrate and analyze the existing studies and to explore research trends and hotspots related to the effects of xenobiotics on glucose metabolism in male testes. All articles were retrieved from the PubMed database, from an inception date up to 10 June 2017. CiteSpace software (version 5.1.R8 SE) was used for the co-word cluster analysis. A total of 165 eligible publications were included in this study. In 1949–1959, only two articles were published. After 1960, the number of articles increased steadily. These articles were published in 97 journals, in particular, in the Indian Journal of Experimental Biology (11 articles, 6.7%). Most of the authors (87.0%) only published one article. Only a few established research teams, mostly from the USA, worked consistently in this field. The main xenobiotics that had been studied were medicine and common environmental pollutants, e.g., gossypol, cadmium, di-n-butyl phthalate, and alpha-chlorohydrin. The hotspot keywords were Sertoli cell, lactate dehydrogenase, 6-phosphate dehydrogenase, oxidative stress, and glucose metabolism. The focus of research had been changed overtime. This is the first bibliometric study between xenobiotics and glucose metabolism in the male testes. The findings suggest that environmental pollutants have become a huge concern, and related research should be strengthened.

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Section: Resultsmentioning

confidence: 99%

Research Trends and Hotspots Analysis Related to the Effects of Xenobiotics on Glucose Metabolism in Male Testes

Fan

et al. 2018

IJERPH

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“…On in viplasma levels of testosterone and the concentration of esterified cholesterol in testis (Bartke -1976;Grizard et al -1983). It has also been shown (Rao and Govindarajulu -1982) that BR induces some modifications in the testicular metabolism and hypospermatogenic conditions. These effects have generally been attributed to the BR-induced hypoprolactinemia, but BR has also been reported to have direct effects on testicular functions.…”

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confidence: 99%

Bromocriptine, a Dopamine Agonist, Directly Inhibits Testosterone Production by Rat Leydig Cells

2009

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We investigated the direct effects of bromocriptine (BR) on both basal and hCG-stimulated testosterone production by rat collagenasedispersed Leydig cells. In a final volume of 2.2 ml, 2.106 Leydig cells were incubated at 33°C for 3 h either alone or with various amounts of hCG (1. 10.102. lo3. lo4 mUI/vial) and BR (1.5 lo-', 1.5 nificantly both basal and hCG-stimulated testosterone production whereas at lower doses, BR had nod effect.These results suggest that the dopamine itself may regulate rat Leydig cell function and that there is room for criticism of BR-induced hypoprolactinemia as an experimental model to study the effect of prolactin on the androgenic function. 1.5 lo-' M); BR was dissolved in 20 p1 of ethanol. BR (1.5 lo-' M) decreased sig-Bromocriptin, ein Dopaminagonist, hemmt direkt die Testosteronproduktion der Leydig-Zellen bei Ratten Zusammenfassung: Wir untersuchten die direkten Effekte des Bromocriptins (BR) sowohl auf die basale als auch auf die HCG-stimulierte Testosteronproduktion bei kollagenase-verteilten Leydig-Zellen von Ratten. In einem End-Volumen von 2,2 ml wurden 2 x 1 O6 Leydig-Zellen bei 33" C fur 3 Stunden entweder allein oder mit verschiedenen Mengen HCG (1,10, lo2, lo3, lo4 mUI/vial) und BR (1,s lo-', 1,s 1 3 lo-' M) inkubiert; BR wurde in 20 p1 Athanol gelost. BR (13 die basale als auch die HCC-stimulierte Testosteronproduktion, wohingegen niedrigere BR-Dosen keinen Effekt hatten. Ratte steuert und dai3 Raum ist fur eine Beurteilung der BR-induzierten Hypoprolaktinamie als einem experimentellen Modell, um die Effekte des Prolaktins auf die androgene Funktion zu untersuchen. M) senkte signifikant sowohl Diese Ergebnisse lassen vermuten, dafi das Dopamin selbst die Leydig-Zellfunktion der Introduction Bromocriptine (2-Br-alpha-ergocryptine mesylate) was specifically developped as an inhibitor of prolactin secretion; this action was explained by a direct stimulation of dopamine receptors (Clark et al. -1978).It decreases the testicular number of LH/hCG receptors, the testicular content and the In rats, treatment with bromocriptine (BR) induces impairment of testicular function.

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Testicular denervation-induced nuclear changes in Leydig cell of hemicastrated adult rats

Bao-chang¹,

Cavicchia²,

Chiocchio³

1998

Tissue and Cell

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Effect of prolactin inhibition by bromocriptine on testicular metabolism in the adult rat

Cited by 6 publications

References 15 publications

Research Trends and Hotspots Analysis Related to the Effects of Xenobiotics on Glucose Metabolism in Male Testes

Research Trends and Hotspots Analysis Related to the Effects of Xenobiotics on Glucose Metabolism in Male Testes

Bromocriptine, a Dopamine Agonist, Directly Inhibits Testosterone Production by Rat Leydig Cells

Testicular denervation-induced nuclear changes in Leydig cell of hemicastrated adult rats

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