Mechanism of Action of Copper 8-Quinolinolate

On 8-Hydroxyquinoline-Zinc Oxide Incompatibility

“…They further found that zinc and iron ions were capable of inhibiting the influence of oxines upon gram-negative bacteria, whereas cobalt had the same effect upon gram positive bacteria. Vicklund et al [6] found that copper-8-quinolinolate had a pronounced antimycotic effect but that the addition of copper sulphate or ferrous sulphate greatly reduced this. Littman [3] concluded from the results of a study on the antimicrobial properties of chlorquinaldol that the fungi cidal effect upon Candida albicans was completely inhibited by the addition of small amounts of Fe ions but that neither human erythrocytes nor whole blood had this effect.…”

DIVISION OF MYCOLOGY: ANTIMYCOTIC EFFECT OF CHLORQUINALDOL*

“…Copper-8-quinolinolate, chemically similar to chlorquinaldol, since it consists of two 8-hydroxyquinoline molecules chelated with copper, is already an outstanding antimildewing agent for textiles, leather, plastics, and wood, but causes discoloration. 28 Mechanism of action of chlorquinaldol. The fungistatic action of 8-hydroxyquinoline was attributed by G. A. Zentmyer 25 to its ability to chelate with metallic cations such as Fe, Cu, Mn, and Zn.…”

Mode of Action of Pesticides, Reversal of Funitoxicity of Copper-8-Quinolinolate

“…Gale (7) distinguished between the reversal of the assimilatory and fermentation processes of the microorganism with different metals. The precipitation concept, however, was soon confronted with data (10,11,16,18) showing that the chelates formed from the reaction of oxine with metals were themselves as toxic as, or even more strongly antimicrobial than oxine. Moreover, the toxicity of the metal chelates could be reversed with metal ions.…”