Mechanism of Action and Selectivity of Quinclorac in Grass Roots

Koo, Suk Jin; Neal, Joseph C.; DiTomaso, Joseph M.

doi:10.1006/pest.1997.2258

Cited by 32 publications

(31 citation statements)

References 15 publications

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“…It was observed, also, that the biosynthesis of the cell wall of E. crus-galli and Digitaria sp. was inhibited in 73 and 60%, respectively, after spraying quinclorac (Koo et al, 1997). This suggests that quinclorac shows similar effects than the ones of other cell wall inhibitors, such as diclobenil and isoxaben (Alonso-Simón et al, 2008).…”

Section: Effect On the Formation Of The Cellular Wallmentioning

confidence: 83%

“…Researches developed during the 1990's showed that quinclorac inhibits the glucose incorporation on the cellular wall, mainly for cellulose (Koo et al, 1996(Koo et al, , 1997. When quinclorac was applied to Zea mays and Digitaria ischaemum, it inhibited their growth, changed the flow of electrons on young tissues and caused the tissue necrosis on the elongation zone of these monocots (Koo et al, 1994).…”

Section: Effect On the Formation Of The Cellular Wallmentioning

confidence: 99%

“…On dicotyledons, it is likely that quinclorac shows auxinic action, acting on the biosynthesis of ethylene, ABA and ROS (Hansen & Grossmann, 2000;van Eerd et al, 2005;Grossmann, 2010). On monocot plants, there are some controversies on its effect, and there is evidence of inhibition of the biosynthesis of the cellular wall (Koo et al, 1996;Koo et al, 1997), as well as ethylene and cyanate biosynthesis (McMahon et al, 2000;Abdallah et al, 2006;Grossmann, 2010), or even the overproduction of ROS (Sunohara & Matsumoto, 2008;Sunohara et al, 2011).…”

Section: Integrative Theorymentioning

confidence: 99%

“…Even after 20 years since the commercial release of quinclorac, there are still some controversies on its mode of action (Alonso-Simón et al, 2008). Among the likely modes of action of quinclorac are the inhibition of the cellular wall (Koo et al, 1996(Koo et al, , 1997, auxinic action (Abdallah et al, 2006;Grossmann, 2010), in addition to the ability to stimulate the production of oxygen reactive species (ROS) (Sunohara et al, 2008(Sunohara et al, , 2010. The objectives of this literature review were to show evidence of three hypotheses on the biochemical action of quinclorac and to suggest an integrative and innovative mode of action.…”

Section: Introductionmentioning

confidence: 99%

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Integrative Theory of the Mode of Action of Quinclorac: Literature Review1

Fipke

Vidal

2016

Planta daninha

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-Quinclorac is a systemic herbicide absorbed by germinating seeds, roots and leaves of seedlings. It is a selective compound for crops such as rice, canola, barley, corn, sorghum, and pasture. Quinclorac can be used to control various monocots and dicotyledonous weed species. The biochemical function of this herbicide in the plant has intrigued scientists for nearly four decades. The objectives of this review are to present evidence of three hypotheses on the biochemical functioning of quinclorac and to propose an integrative mode of action. The first theory on the mode of action of quinclorac is supported by evidence of inhibition of incorporation of C 14 -glucose into cellulose and hemicellulose, thus, affecting the cell wall synthesis. The second hypothesis suggests that quinclorac acts as an auxin in broadleaved weed species. In grass species, however, this herbicide appears to stimulate the activity of the 1-aminocyclopropane-1-carboxylate synthase enzyme and, subsequently, to increase the ethylene production; also, it seems to increase the cyanide acid content to phytotoxic levels. A third hypothesis to explain the harmful effect in some plant species is the formation of reactive oxygen species (ROS). Apparently, these processes are not mutually exclusive; therefore, an integrative theory for the action of quinclorac is suggested. It is theorized that the aforementioned biochemical activities are interconnected and can be the phytotoxic backbone to explain the herbicidal effect depending on the plant species and the plant growth stage, among other factors.Keywords: cellulose biosynthesis-inhibitor, cyanide, auxinic herbicide, reactive oxygen species. Palavras-chave: inibidor da síntese de celulose, herbicida auxínico, cianeto, espécies reativas de oxigênio. RESUMO

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Section: Effect On the Formation Of The Cellular Wallmentioning

confidence: 83%

Section: Effect On the Formation Of The Cellular Wallmentioning

confidence: 99%

Section: Integrative Theorymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Integrative Theory of the Mode of Action of Quinclorac: Literature Review1

Fipke

Vidal

2016

Planta daninha

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“…It was previously reported that quinclorac inhibits the incorporation of glucose into cellulose in a dose and time-dependent manner (Koo et al, 1996(Koo et al, , 1997, being regarded as a cellulose biosynthesis inhibitor (CBI) (Vaughn, 2002). However, other works challenged the correlation of cellulose inhibition effect and quinclorac mechanism of action (Tresch and Grossmann, 2003).…”

Section: Introductionmentioning

confidence: 99%

Quinclorac-habituation of bean ( Phaseolus vulgaris ) cultured cells is related to an increase in their antioxidant capacity

Largo-Gosens

Castro

Alonso‐Simón

et al. 2016

Plant Physiology and Biochemistry

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The habituation of bean cells to quinclorac did not rely on cell wall modifications, contrary to what it was previously observed for the well-known cellulose biosynthesis inhibitors dichlobenil or isoxaben. The aim of the present study was to investigate whether or not the bean cells habituation to quinclorac is related to an enhancement of antioxidant activities involved in the scavenging capacity of reactive oxygen species. Treating non-habituated bean calluses with 10 μM quinclorac reduced the relative growth rate and induced a two-fold increase in lipid peroxidation. However, the exposition of quinclorac-habituated cells to a concentration of quinclorac up to 30 μM neither affected their growth rate nor increased their lipid peroxidation levels. Quinclorac-habituated calluses had significantly higher constitutive levels of three antioxidant activities (class-III peroxidase, glutathione reductase, and superoxide dismutase) than those observed in non-habituated calluses, and the treatment of habituated calluses with 30 μM quinclorac significantly increased the level of class III-peroxidase and superoxide dismutase. The results reported here indicate that the process of habituation to quinclorac in bean callus-cultured cells is related, at least partially, to the development of a stable antioxidant capacity that enables them to cope with the oxidative stress caused by quinclorac. Class-III peroxidase and superoxide dismutase activities could play a major role in the quinclorac-habituation. Changes in the antioxidant status of bean cells were stable, since the increase in the antioxidant activities were maintained in quinclorac-dehabituated cells.

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A novel thiazolidinone herbicide is a potent inhibitor of glucose incorporation into cell wall material†

Sharples¹,

Hawkes²,

Mitchell³

et al. 1998

Pestic. Sci.

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:5-tert-Butyl-carbamoyloxy-3-(3-triÑuoromethyl) phenyl-4-thiazolidinone (compound 1), a representative of a novel class of thiazolidinone herbicides, shows potential for the pre-emergence control of grasses and smallseeded broad-leaved weeds in crops such as soyabean. This compound powerfully inhibited the growth and lateral branching of the roots of agar-grown seedlings of susceptible species but had no apparent e †ect on the growth of Escherichia coli, Aspergillus nidulans, Fusarium culmorum or of insects cells in liquid culture. It inhibited the growth of plant (Daucus carota and Zea mays) cells in liquid culture and this inhibition was not reversed by addition to the medium of mixtures of either amino acids or of nucleosides. It did not inhibit fatty acid biosynthesis, respiration, the biosynthesis of sterols, or the biosynthesis of protein in the systems examined herein. By contrast, it induced potent c.50 nM) and (IC 50 rapid inhibition of the incorporation of [3H]glucose into the acid-insoluble cellwall fraction of roots. Thus, compound 1 exerts its herbicidal e †ect, directly or indirectly, through inhibition of the biosynthesis of cellulose and cellulose-like polysaccharides, in a manner similar to isoxaben and dichlobenil. Mutant lines of Arabidopsis thaliana selected for resistance to isoxaben were cross-resistant to compound 1. Consistent with the selective herbicidal activity observed, the compound was a potent inhibitor of [3H]glucose incorporation into the polysaccharide of seedling roots of Zea mays and of Setaria viridis but only relatively weakly active on Glycine max and Ipomoea hederacea. Given that compound 1 appeared to be metabolised only slowly and that [3H]glucose incorporation experiments were conducted within a total period of less than 90 min, it seems probable that, as in the case of the acetyl CoA carboxylase-inhibitor graminicides, the observed selectivity is determined by species-dependent di †erences at the (in this case unknown) molecular target site for the herbicide.1998 Society ( of Chemical Industry Pestic. Sci., 54, 368È376 (1998)

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Mechanism of Action and Selectivity of Quinclorac in Grass Roots

Cited by 32 publications

References 15 publications

Integrative Theory of the Mode of Action of Quinclorac: Literature Review1

Integrative Theory of the Mode of Action of Quinclorac: Literature Review1

Quinclorac-habituation of bean ( Phaseolus vulgaris ) cultured cells is related to an increase in their antioxidant capacity

A novel thiazolidinone herbicide is a potent inhibitor of glucose incorporation into cell wall material†

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