Mechanism of action and fate of the fungicide chlorothalonil (2,4,5,6-tetrachloroisophthalonitrile) in biological systems

Long, John W.; Siegel, Malcolm R.

doi:10.1016/0009-2797(75)90069-1

Cited by 42 publications

(16 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…gerberae. Long and Siegel (1975) found out amount of chlorothalonil bound to protein was related to enzyme inhibition and postulated that chlorothalonil affects catalytic activity by reacting with the 4 sulfhyldryl sites responsible for binding glyceraldehyde-3-phosphate (GAP).…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Efficacy of Fungicides Against Fusarium oxysporum f. sp. lentis in Vitro at Lamjung, Nepal

Dahal¹,

Shrestha²

2018

J. Inst. Agric. Anim. Sci.

View full text Add to dashboard Cite

Fusarium is a soil borne pathogen which is common in almost all types of soil causing heavy losses in the crop production. Long term survival of pathogen in the soil as chlamydospores has increased its threat making it a highly devastating disease. High accessibility and simple application process of chemical control method has made it an effective and highly adopted approach of eliminating disease causing organisms. The present study was conducted in IAAS, Lamjung Campus to test the efficacy of fungicides in-vitro by poisoned food technique in PDA medium against Fusarium oxysporum f. sp. lentis. The fungicides tested were Carbendazim (50% WP), Chlorothalonil (75% WP) and Dithane M-45 (75% WP) at three different concentrations (100 ppm, 150 ppm and 200 ppm). The treatments were arranged in complete randomized design and replicated five times. The measurement of diameter of the fungal mycelium was taken 8 times at 48 hours interval until the fungus nearly covered the plate in control treatment and inhibition percent of the chemicals were calculated. All the fungicides inhibited the fungal growth significantly, among which carbendazim was highly effective in all the concentrations reducing 100% of mycelial growth followed by chlorothalonil. Dithane M-45 showed least inhibition i.e. 26.62% in 200 ppm (day 13). The chemicals exhibited increased tendency of inhibition with increased concentration.

show abstract

Section: Resultsmentioning

confidence: 99%

Evaluation of Efficacy of Fungicides Against Fusarium oxysporum f. sp. lentis in Vitro at Lamjung, Nepal

Dahal¹,

Shrestha²

2018

J. Inst. Agric. Anim. Sci.

View full text Add to dashboard Cite

show abstract

“…), Phytophthora dieback diseases and powdery mildews (Bowen and Young, 1995). Toxicity to fungal cells results from binding of chlorothalonil with sulfhydryl groups of cellular proteins leading to irreversible enzyme deactivation (Long and Seigle, 1975). Between 1990 and 1996, 2% of the total chlorothalonil (a.i.)…”

Section: Fungicides In Studymentioning

confidence: 99%

Effect of Integrated Pest Management Strategies on Chlorothalonil, Metalaxyl, and Thiophanate-methyl Runoff at a Container Nursery

Briggs¹,

Whitwell²,

Fernandez³

et al. 2002

jashs

View full text Add to dashboard Cite

Field research was conducted at a container nursery to investigate fungicide movement in runoff water. Fungicides were applied as either a preventative treatment to all container plants, or as a component of an integrated pest management (IPM) program in which fungicides were only applied to plants showing signs of pathogen infestation. Thiophanate-methyl and chlorothalonil were applied in July and August 1998, and metalaxyl was applied in September 1998. Runoff water was sampled on the day after application (first irrigation after pesticide application) through three pulse irrigation cycles. Total amounts of thiophanate-methyl and chlorothalonil in runoff water were 7% and 4%, respectively, of applied amount in July. In August, 2% and 4% of thiophanate-methyl and chlorothalonil were found from the preventative treatment. Of the applied metalaxyl, 25% was detected in runoff water for the first irrigation event after application from the preventative treatment. Metalaxyl is a highly water soluble pesticide and nontarget losses from the granular application contributed to the large amounts detected. Total amounts of thiophanate-methyl, chlorothalonil and metalaxyl detected in runoff from the IPM treatment were 25% of amounts from the preventative treatment. No treatment differences were found in container plant salability or in the number of culls at the end of the study.

show abstract

“…[42][43][44][45] The absorbance intensity is proportional to the concentration of NADH. Whereas, previous investigations 39 have conrmed that inhibition of GAPDH by CTL was via forming a co-valently bond with amino acid residue Cys 149 in the active pocket ( Fig. S1 †) that required for NAD binding.…”

Section: Resultsmentioning

confidence: 76%

“…1 illustrates the sensing mechanism for colorimetric sensor of CTL based on enzymatic reaction catalyzed by GAPDH coupled with PMS-NBT chromogenic system. This method relies on the fact that CTL is an inhibitor of specic nicotinamide adenine dinucleotide (NAD) thiol-dependent glycolytic enzyme-GAPDH, 39,40 leading to a decrease in production of NADH, which fails to induce a color change from yellow to blue of PMS-NBT chromogenic system. According to previous reports, the native GAPDH can catalyze the oxidation of GAP 38 into gluconolactone-6-phosphate (1,3-DPG), accompanied with reduction of NAD + into NADH.…”

Section: Resultsmentioning

confidence: 99%

Antibody-free colorimetric detection of chlorothalonil in cucumberviathe inhibition of an enzyme-triggered reaction

et al. 2019

View full text Add to dashboard Cite

show abstract

Mechanism of action and fate of the fungicide chlorothalonil (2,4,5,6-tetrachloroisophthalonitrile) in biological systems

Cited by 42 publications

References 21 publications

Evaluation of Efficacy of Fungicides Against Fusarium oxysporum f. sp. lentis in Vitro at Lamjung, Nepal

Evaluation of Efficacy of Fungicides Against Fusarium oxysporum f. sp. lentis in Vitro at Lamjung, Nepal

Effect of Integrated Pest Management Strategies on Chlorothalonil, Metalaxyl, and Thiophanate-methyl Runoff at a Container Nursery

Antibody-free colorimetric detection of chlorothalonil in cucumberviathe inhibition of an enzyme-triggered reaction

Contact Info

Product

Resources

About