Mechanism of a long-term controlled drug release system based on simple blended electrospun fibers

Aligned Fingolimod-Releasing Electrospun Fibers Increase Dorsal Root Ganglia Neurite Extension and Decrease Schwann Cell Expression of Promyelinating Factors

“…Fitting kinetics models to the release data allows for a more thorough investigation into the mechanisms of fingolimod release from the PLGA fibers. The Higuchi model, which describes drug release from a matrix system, was a good fit for each of the fiber groups, indicating that the drug release mechanism is controlled by diffusion of fingolimod from the PLGA fibers (Higuchi, 1963;Dash et al, 2010;Wu et al, 2020). Furthermore, the Korsmeyer-Peppas model was fit to the release data, as this model is used to describe drug release from swellable, polymeric systems like that of the PLGA fibers (Ritger and Peppas, 1987;Dash et al, 2010).…”

“…This model was also found to be a good fit for the fingolimod release data, and the release exponent ( n ) for each fiber group indicated release via anomalous transport. Anomalous transport refers to a combination of Fickian diffusion and case II transport, indicating that the drug release is controlled by a combination of diffusion and swelling/erosion ( Ritger and Peppas, 1987 ; Sujja-areevath et al, 1998 ; Siepmann and Peppas, 2001 ; Wu et al, 2020 ). These findings corroborate the speculations made in the previous paragraph that fingolimod release from the PLGA fibers is controlled by a combination of diffusion, swelling, and erosion.…”

“…To better understand the dissolution of fingolimod from the PLGA fibers, we assessed how well several widely used mathematical models fit the cumulative fingolimod release data, including the zero-order model, first-order model, Higuchi model, Korsmeyer–Peppas model, and Hixson–Crowell’s cube root model ( Higuchi, 1963 ; Ritger and Peppas, 1987 ; Costa and Sousa Lobo, 2001 ; Siepmann and Peppas, 2001 ; Dash et al, 2010 ; de Mello and Ricci-Júnior, 2011 ; da Costa et al, 2015 ; Moydeen et al, 2018 ; Paolino et al, 2019 ; Pourtalebi Jahromi et al, 2020 ; Wu et al, 2020 ). The mathematical equation and axes of the plot for each model are listed in Table 3 .…”

Electrospun progesterone‐loaded cellulose acetate nanofibers and their drug sustained‐release profiles

“…[1,4] Compared with ordinary dosage methods (ie, oral ingestion and intravenous injection), the controlled release formulations display more precise dosage control, decrease side effects, and reduce dosages of drug necessary to induce similar therapeutic effects, improving patient compliance and convenience. [5] The release effectiveness of the encapsulated drug depends on its loading efficacy and release mechanisms, including the swelling, diffusion, desorption, and degradation of the matrix. [6] Hence, an adequate DDS is imperative to ensure a specific release profile that achieves the desired effect.…”

Electroresponsive Silk-Based Biohybrid Composites for Electrochemically Controlled Growth Factor Delivery

“…By day 10, most of the loaded therapeutic had been released from the samples via electrical stimulation. The release of drugs over prolonged time periods is necessary for tissue repair and regeneration [ 21 , 50 ]; it obviates the need for repeated high dosing and improves the therapeutic index [ 17 ]. In addition to providing long-term release, the system described in this work could be further modulated in terms of the frequency pulse and duration used for stimulation.…”