Mechanism for the differential toxicity of neonicotinoid insecticides in the honey bee, Apis mellifera

Iwasa, Takao; Motoyama, N.; Ambrose, John T.; Roe, R. Michael

doi:10.1016/j.cropro.2003.08.018

Cited by 678 publications

(615 citation statements)

References 14 publications

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“…The authors argue that their low rates of significant synergies between neonicotinoids and fungicides was because of their lower, more field-realistic fungicide doses of 161-447 ng/bee compared to 10,000 ng/bee used by Iwasa et al (2004), an early study demonstrating this interaction. The values of 161-447 ng/bee were calculated as realistic worstcase exposures based on approved application rates for UK crops.…”

Section: Other Pollinatorsmentioning

confidence: 99%

An update of the Worldwide Integrated Assessment (WIA) on systemic insecticides. Part 2: impacts on organisms and ecosystems

Pisa

Goulson

Yang

et al. 2017

Environ Sci Pollut Res

190

144

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New information on the lethal and sublethal effects of neonicotinoids and fipronil on organisms is presented in this review, complementing the previous Worldwide Integrated Assessment (WIA) in 2015. The high toxicity of these systemic insecticides to invertebrates has been confirmed and expanded to include more species and compounds. Most of the recent research has focused on bees and the sublethal and ecological impacts these insecticides have on pollinators. Toxic effects on other invertebrate taxa also covered predatory and parasitoid natural enemies and aquatic arthropods. Little new information has been gathered on soil organisms. The impact on marine and coastal ecosystems is still largely uncharted. The chronic lethality of neonicotinoids to insects and crustaceans, and the strengthened evidence that these chemicals also impair the immune system and reproduction, highlights the dangers of this particular insecticidal class (neonicotinoids and fipronil), with the potential to greatly decrease populations of arthropods in both terrestrial and aquatic environments. Sublethal effects on fish, reptiles, frogs, birds, and mammals are also reported, showing a better understanding of the mechanisms of toxicity of these insecticides in vertebrates and their deleterious impacts on growth, reproduction, and neurobehaviour of most of the species tested. This review concludes with a summary of impacts on the ecosystem services and functioning, particularly on pollination, soil biota, and aquatic invertebrate communities, thus reinforcing the previous WIA conclusions .

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Section: Other Pollinatorsmentioning

confidence: 99%

An update of the Worldwide Integrated Assessment (WIA) on systemic insecticides. Part 2: impacts on organisms and ecosystems

Pisa

Goulson

Yang

et al. 2017

Environ Sci Pollut Res

190

144

View full text Add to dashboard Cite

show abstract

“…However, neonicotinoids such as imidacloprid, clothianidin, and thiamethoxam are extremely toxic to bees with lethal and sublethal effects depending on the level of exposure. The lethal dose (LD 50 ) (the dose at which half of the exposed bees die) for clothianidin is 2.8 -3.7 ng per bee for oral ingestion; for thiamethoxam, it is 4 -5 ng/bee; and for imidacloprid, it is 3.7 ng/bee (Iwasa et al, 2004;Decourtye and Devillers, 2010;Laurino et al, 2011). Moreover, systemic neonicotinoids may persist for a long time in plant tissues, plant parts, or soil.…”

Section: Introductionmentioning

confidence: 99%

Effects of exposure of honey bee colonies to neonicotinoid seed–treated maize crops

Pohorecka¹,

Skubida²,

Semkiw³

et al. 2013

Journal of Apicultural Science

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A b s t r a c t The effects to honeybee colonies (Apis mellifera L.) during and after exposure to flowering maize (Zea mays L.), grown from seeds coated with clothianidin and imidacloprid was assessed in field-realistic conditions. The experimental maize crops were adjacent to the other flowering agriculture plants. Honey bee colonies were placed in three differently protected maize fields throughout the blooming period, and thereafter they were transferred to a stationary apiary. Samples of pollen loads, bee bread, and adult bees were collected and analyzed for neonicotinoid residues. To ensure high specificity and sensitivity of detection of the analyzed pesticides, a modified QuEChERS extraction method and liquid chromatography coupled with tandem mass spectrometry were used. Clothianidin was detected only in the samples of pollen loads. Their residue levels ranged from 10.0 to 41.0 ng/g (average 27.0 ng/g). Imidacloprid was found in no investigated sample. No negative effects of neonicotinoid seed-treated maize on the development and long-term survival of honey bee colonies were observed. The low proportion of Zea mays pollen in total bee-collected pollen during the maize flowering period was noted. The findings suggest that maize plants are less attractive forage for honey bees than phacelia (Phacelia tanacetifolia Benth.), buckwheat (Fagopyrum Mill.), white clover (Trifolium repens L.), goldenrod (Solidago L.), and vegetation from Brassicaceae family. The results indicate a possibility of reducing the risk of bees being exposed to the toxic effect of insecticidal dusts dispersed during maize sowing by seeding, in the areas surrounding maize crops, plants that bloom later in the year.

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“…Two of these pesticides, propiconazole and tebuconazole are triazole fungicides, displaying similar physiological effects: they are 14α-demethylase inhibitors and also referred to as ergosterol biosynthesis inhibitors via cytochrome P450 inhibition (Egaas et al, 1999;Iwasa et al, 2004). Tebuconazole is frequently used in agricultural areas (Berenzen et al, 2005) and propiconazole is one of the most widely distributed pesticides in the world (Kronvang et al, 2003).…”

Section: Modes Of Action Of the Tested Chemicalsmentioning

confidence: 99%

Combined Exposure to Mixture of Chemicals. An Impossible Challenge?

Degiorgi¹,

Adam²,

Gregorio³

2011

Pesticides - The Impacts of Pesticides Exposure

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Mechanism for the differential toxicity of neonicotinoid insecticides in the honey bee, Apis mellifera

Cited by 678 publications

References 14 publications

An update of the Worldwide Integrated Assessment (WIA) on systemic insecticides. Part 2: impacts on organisms and ecosystems

An update of the Worldwide Integrated Assessment (WIA) on systemic insecticides. Part 2: impacts on organisms and ecosystems

Effects of exposure of honey bee colonies to neonicotinoid seed–treated maize crops

Combined Exposure to Mixture of Chemicals. An Impossible Challenge?

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