Mechanism for sonocoating a polymer surface with nano-hydroxyapatite

Woźniak, Bartosz; Szałaj, Urszula; Chodara, Agnieszka; Mizeracki, Jan; Łojkowski, Maciej; Myszka, D.; Łojkowski, Witold

doi:10.1016/j.matlet.2019.04.078

Cited by 14 publications

(13 citation statements)

References 17 publications

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“…layer is created on a polymer was recently described by Wozniak, et al [42]. The nanoHAP layer(s) is grown laterally in a dendrite-like pattern on the surface.…”

Section: Introductionmentioning

confidence: 99%

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Drug-Releasing Antibacterial Coating Made from Nano-Hydroxyapatite Using the Sonocoating Method

et al. 2021

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Medical implant use is associated with a risk of infection caused by bacteria on their surface. Implants with a surface that has both bone growth-promoting properties and antibacterial properties are of interest in orthopedics. In the current study, we fabricated a bioactive coating of hydroxyapatite nanoparticles on polyether ether ketone (PEEK) using the sonocoating method. The sonocoating method creates a layer by immersing the object in a suspension of nanoparticles in water and applying a high-power ultrasound. We show that the simple layer fabrication method results in a well-adhering layer with a thickness of 219 nm to 764 nm. Dropping cefuroxime sodium salt (Cef) antibiotic on the coated substrate creates a layer with a drug release effect and antibacterial activity against Staphylococcus aureus. We achieved a concentration of up to 1 mg of drug per cm2 of the coated substrate. In drug release tests, an initial burst was observed within 24 h, accompanied by a linear stable release effect. The drug-loaded implants exhibited sufficient activity against S. aureus for 24 and 168 h. Thus, the simple method we present here produces a biocompatible coating that can be soaked with antibiotics for antibacterial properties and can be used for a range of medical implants.

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“…layer is created on a polymer was recently described by Wozniak, et al [42]. The nanoHAP layer(s) is grown laterally in a dendrite-like pattern on the surface.…”

Section: Introductionmentioning

confidence: 99%

“…The advantage of this method is that it is a single, easy step at low cost and low temperature. The mechanism by which the nanoHAP layer is created on a polymer was recently described by Wozniak, et al [ 42 ]. The nanoHAP layer(s) is grown laterally in a dendrite-like pattern on the surface.…”

Section: Introductionmentioning

confidence: 99%

Drug-Releasing Antibacterial Coating Made from Nano-Hydroxyapatite Using the Sonocoating Method

et al. 2021

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“…It is suspected that the nHA layers produced by means of sonocoating attached firmly to the fibers, forming a uniform layer. This strong attachment may be attributed to the lateral growth of the nanoparticle layer during the process of sonocoating previously reported by Woźniak et al [62]. Areas where the layer detached or dissolved and the polymer was exposed to the test fluids started to degrade the prior nHA covered surfaces.…”

Section: Discussionmentioning

confidence: 54%

“…Sonocoating, especially of bone regrowth scaffolds with nHA, was previously described [56,60]. It was applied to coat various substrates including 3D-printed and electrospun polymers or sintered ceramics [56,60,61,62]. Nevertheless, it is not yet possible to achieve an almost 100% uniform coverage of the electrospun fibers.…”

Section: Introductionmentioning

confidence: 99%

Polymer Membranes Sonocoated and Electrosprayed with Nano-Hydroxyapatite for Periodontal Tissues Regeneration

et al. 2019

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Diseases of periodontal tissues are a considerable clinical problem, connected with inflammatory processes and bone loss. The healing process often requires reconstruction of lost bone in the periodontal area. For that purpose, various membranes are used to prevent ingrowth of epithelium in the tissue defect and enhance bone regeneration. Currently-used membranes are mainly non-resorbable or are derived from animal tissues. Thus, there is an urgent need for non-animal-derived bioresorbable membranes with tuned resorption rates and porosity optimized for the circulation of body nutrients. We demonstrate membranes produced by the electrospinning of biodegradable polymers (PDLLA/PLGA) coated with nanohydroxyapatite (nHA). The nHA coating was made using two methods: sonocoating and electrospraying of nHA suspensions. In a simulated degradation study, for electrosprayed membranes, short-term calcium release was observed, followed by hydrolytic degradation. Sonocoating produced a well-adhering nHA layer with full coverage of the fibers. The layer slowed the polymer degradation and increased the membrane wettability. Due to gradual release of calcium ions the degradation-associated acidity of the polymer was neutralized. The sonocoated membranes exhibited good cellular metabolic activity responses against MG-63 and BJ cells. The collected results suggest their potential use in Guided Tissue Regeneration (GTR) and Guided Bone Regeneration (GBR) periodontal procedures.

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“…Exploitation of the specific properties of nanomaterials, which are not observed in their microcrystalline counterparts, is a fundamental basis of nanotechnology [1]. Due to these properties, nanoparticles are increasingly applied as additives, modifiers of composite materials, reaction catalysts [2,3], nano-solders [4,5], sensors [6,7,8], coatings [9,10] and materials for medical applications [11,12,13,14,15,16]. Over the past few decades, millions of tons of nanoparticles have been produced [17].…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle Size Effect on Water Vapour Adsorption by Hydroxyapatite

et al. 2019

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Handling and properties of nanoparticles strongly depend on processes that take place on their surface. Specific surface area and adsorption capacity strongly increase as the nanoparticle size decreases. A crucial factor is adsorption of water from ambient atmosphere. Considering the ever-growing number of hydroxyapatite nanoparticles applications, we decided to investigate how the size of nanoparticles and the changes in relative air humidity affect adsorption of water on their surface. Hydroxyapatite nanoparticles of two sizes: 10 and 40 nm, were tested. It was found that the nanoparticle size has a strong effect on the kinetics and efficiency of water adsorption. For the same value of water activity, the quantity of water adsorbed on the surface of 10 nm nano-hydroxyapatite was five times greater than that adsorbed on the 40 nm. Based on the adsorption isotherm fitting method, it was found that a multilayer physical adsorption mechanism was active. The number of adsorbed water layers at constant humidity strongly depends on particles size and reaches even 23 layers for the 10 nm particles. The amount of water adsorbed on these particles was surprisingly high, comparable to the amount of water absorbed by the commonly used moisture-sorbent silica gel.

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Mechanism for sonocoating a polymer surface with nano-hydroxyapatite

Cited by 14 publications

References 17 publications

Drug-Releasing Antibacterial Coating Made from Nano-Hydroxyapatite Using the Sonocoating Method

Drug-Releasing Antibacterial Coating Made from Nano-Hydroxyapatite Using the Sonocoating Method

Polymer Membranes Sonocoated and Electrosprayed with Nano-Hydroxyapatite for Periodontal Tissues Regeneration

Nanoparticle Size Effect on Water Vapour Adsorption by Hydroxyapatite

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