2019
DOI: 10.1021/acs.jafc.9b06263
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Mechanism for Inhibition of Folic Acid Photodecomposition by Various Antioxidants

Abstract: Folic acid, a synthetic form of folate, is a water-soluble vitamin that is essential during periods of rapid cell division and growth. However, it decomposes upon ultraviolet irradiation to form inactive photoproducts. In this study, the protective effect and mechanisms of antioxidants, including cinnamic acids, flavonoids, catechol and its derivatives, stilbenes, p-benzoquinone and its derivatives, isoprenoids, curcumin, oleic acid, and linoleic acid, against folic acid photodecomposition were investigated by… Show more

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Cited by 14 publications
(10 citation statements)
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References 53 publications
(127 reference statements)
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“…Compounds known generically as antioxidants (flavonoids, cinnamic acids, stilbene, etc.) can influence the breakdown of folic acid, proving to be useful protectors [20]. Folates found in plasma have low affinity for proteins, instead folic acid could react with several proteins: through both hydrophobic and hydrophilic interactions it can interact with human and bovine serum albumin (due to tryptophan in their structure), with lactoferrin forming saturated reactive complexes, with β-casein forming stable complexes due to certain hydrophobic parts that are found in both structures [21][22][23].…”
Section: Chemical Perspectivesmentioning
confidence: 99%
“…Compounds known generically as antioxidants (flavonoids, cinnamic acids, stilbene, etc.) can influence the breakdown of folic acid, proving to be useful protectors [20]. Folates found in plasma have low affinity for proteins, instead folic acid could react with several proteins: through both hydrophobic and hydrophilic interactions it can interact with human and bovine serum albumin (due to tryptophan in their structure), with lactoferrin forming saturated reactive complexes, with β-casein forming stable complexes due to certain hydrophobic parts that are found in both structures [21][22][23].…”
Section: Chemical Perspectivesmentioning
confidence: 99%
“…However, the stability of antioxidants could be improved through shielding them from the harsh environment upon complexation and encapsulation by proteins . Moreover, antioxidants may protect photosensitizers against photodecomposition . Therefore, the study on interaction among proteins, photosensitizers, and antioxidants would shed more light on the sensitization and stabilization mechanisms under light illumination, contributing to designing food products with desirable chemical stability.…”
Section: Introductionmentioning
confidence: 99%
“…β-Casein (24 kDa) accounts for about a third of total caseins, a major protein in bovine milk . The goal of this study is to explain the interaction between the proteins and FA under UVA irradiation in the absence and presence of CA, which at a concentration of 1 μM could reportedly inhibit the photodecomposition of 10 μM FA . The susceptibility of proteins to indirect photo-oxidation was characterized by amino acid composition and structural change.…”
Section: Introductionmentioning
confidence: 99%
“…Although the topic of antioxidants (AO) research dates to the beginning of the last century, it is still relevant [ 1 , 2 , 3 ]. This is due to the great variety of biological mechanisms of antioxidant action in the human body [ 4 , 5 , 6 , 7 , 8 ] and, accordingly, the lack of possibility to create a universal method of antioxidant research. One of the relevant directions in this area is the creation of approaches to the determination of integral parameters of antioxidant and antiradical capacity/activity because the efficiency of the body’s antioxidant system may not be related to the content of a particular compound, but reflects the property of the system as a whole.…”
Section: Introductionmentioning
confidence: 99%