2020
DOI: 10.37358/rc.20.7.8267
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Folates and Anti-folates � Chemical Perspectives, in vitro and in ovo Assessments

Abstract: Folates participate in DNA replication reactions, act as a substrate in enzymatic reactions related to amino acid synthesis and vitamin metabolism while antifolates participate in reactions that inhibit the formation of tetrahydrofolate with consequences on protein and nucleic acid synthesis and implicitly on growth and development both types of cells, healthy and diseased. In the present study, the viability of healthy cells, keratinocytes and human fibroblasts was evaluated in the presence of three folates (… Show more

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