1973
DOI: 10.1128/aac.3.3.373
|View full text |Cite
|
Sign up to set email alerts
|

Mechanism by Which Hydnocarpic Acid Inhibits Mycobacterial Multiplication

Abstract: Recent work in this laboratory has shown that hydnocarpic acid (HA), a principal constituent of chaulmoogra oil, inhibits multiplication in vitro of a number of mycobacterial species. This activity of HA was not shared by several straight-chain fatty acids and by dihydrochaulmoogric acid. A study of the interaction of HA with biotin has been undertaken, based on a structural analogy between biotin and the cyclopentenyl fatty acid. The multiplication of a strain of Mycobacterium intracellulare susceptible to 2 … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
8
0

Year Published

1981
1981
2023
2023

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 19 publications
(9 citation statements)
references
References 8 publications
0
8
0
Order By: Relevance
“…Chaulmoogra oil has been used as the main treatment for leprosy in Indian and Chinese traditional medicine and, subsequently, in the West before the era of sulfones and antibiotics (27). Hydnocarpic acid had been identified as the principle active ingredient of the oil and showed antimycobacterial activity, apparently acting as an antagonist of biotin (28). The substance was marketed by Burroughs Wellcome as Alepol.…”
Section: Resultsmentioning
confidence: 99%
“…Chaulmoogra oil has been used as the main treatment for leprosy in Indian and Chinese traditional medicine and, subsequently, in the West before the era of sulfones and antibiotics (27). Hydnocarpic acid had been identified as the principle active ingredient of the oil and showed antimycobacterial activity, apparently acting as an antagonist of biotin (28). The substance was marketed by Burroughs Wellcome as Alepol.…”
Section: Resultsmentioning
confidence: 99%
“…One of its compounds, hydnocarpic acid (C 16 H 28 O 2 ), has an in vitro activity against some mycobacteria species. It is however inactive against M. leprae [53].…”
Section: Treatmentsmentioning
confidence: 96%
“…Hydnocarpin and its derivatives show interesting biological activities such as being efficient inhibitors of the multidrug resistance (MDR) efflux pump (e.g., of Staphylococcus aureus ): this activity had been serendipiously employed in traditional medicine (without knowledge of the mechanism) in the treatment of leprosy with chaulmoogra oil. This oil, which is obtained from fruits (kernels) of H. wightiana , contains besides hydnocarpin mainly cyclopentenoic fatty acids [ 16 ], which show pronounced antibiotic activity and inhibit multiplication of mycobacteria [ 17 ]. Combination of these antibiotics together with hydnocarpin (MDR inhibitor) helped to treat such a persistent disease like leprosy caused by M. leprae .…”
Section: Introductionmentioning
confidence: 99%