Mechanism-based therapies for pain

Block, Brian M.; Hurley, Robert W.; Raja, Srinivasa N.

doi:10.1358/dnp.2004.17.3.829015

Cited by 11 publications

(10 citation statements)

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“…Importantly, contralateral intra-hippocampal TNF nanoplex injection decreased CCI-induced bioactive TNF levels (in contralateral hippocampus and ipsilateral sciatic nerve) and completely alleviated thermal hyperalgesia, as well as delayed development of mechanical allodynia. Since hyperalgesia and allodynia differ for time of onset and TNF nanoplex therapy was more effective for hyperalgesia than allodynia, these findings suggest that thermal hyperalgesia and mechanical allodynia are separate mechanisms [1, 5]. However, our findings support that both symptoms of chronic pain syndromes require hippocampal TNF production.…”

Section: Discussionmentioning

confidence: 51%

Chronic constriction injury-induced nociception is relieved by nanomedicine-mediated decrease of rat hippocampal tumor necrosis factor

Gerard

Spengler²,

Bonoiu

et al. 2015

Pain

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Section: Discussionmentioning

confidence: 51%

Chronic constriction injury-induced nociception is relieved by nanomedicine-mediated decrease of rat hippocampal tumor necrosis factor

Gerard

Spengler²,

Bonoiu

et al. 2015

Pain

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“…In contrast to heavy involvement of inflammatory mediators in pain mechanisms [64], given the redundancy in and robustness of the immune system, expectation of profound analgesia by antagonizing a single mediator appears impracticable.…”

Section: Therapeutic Opportunitiesmentioning

confidence: 99%

Nociception and role of immune system in pain

2014

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Both pain and inflammation are protective responses. However, these self-limiting conditions (with well-established negative feedback loops) become pathological if left uncontrolled. Both pain and inflammation can interact with each other in a multi-dimensional manner. These interactions are known to create an array of 'difficult to manage' pathologies. This review explains in detail the role of immune system and the related cells in peripheral sensitization and neurogenic inflammation. Various neuro-immune interactions are analyzed at peripheral, sensory and central nervous system levels. Innate immunity plays a critical role in central sensitization and in establishing acute pain as chronic condition. Moreover, inflammatory mediators also exhibit psychological effects, thus contributing towards the emotional elements associated with pain. However, there is also a considerable anti-inflammatory and analgesic role of immune system. This review also attempts to enlist various novel pharmacological approaches that exhibit their actions through modification of neuro-immune interface.

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“…[137] Molecular mechanisms in pain perception[138] will direct mechanism-based drug therapy prescription[139] in palliative care, whereas mechanism-based understanding will direct physical therapy treatment decision-making and efficient treatment delivery in patients with cancer pain. Pain relieving therapy should always accompany disease-modifying therapy and can never substitute the latter.…”

Section: Discussionmentioning

confidence: 99%

Cancer pain: A critical review of mechanism-based classification and physical therapy management in palliative care

Kumar¹

2011

Indian J Palliat Care

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Mechanism-based classification and physical therapy management of pain is essential to effectively manage painful symptoms in patients attending palliative care. The objective of this review is to provide a detailed review of mechanism-based classification and physical therapy management of patients with cancer pain. Cancer pain can be classified based upon pain symptoms, pain mechanisms and pain syndromes. Classification based upon mechanisms not only addresses the underlying pathophysiology but also provides us with an understanding behind patient's symptoms and treatment responses. Existing evidence suggests that the five mechanisms – central sensitization, peripheral sensitization, sympathetically maintained pain, nociceptive and cognitive-affective – operate in patients with cancer pain. Summary of studies showing evidence for physical therapy treatment methods for cancer pain follows with suggested therapeutic implications. Effective palliative physical therapy care using a mechanism-based classification model should be tailored to suit each patient's findings, using a biopsychosocial model of pain.

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Mechanism-based therapies for pain

Cited by 11 publications

References 0 publications

Chronic constriction injury-induced nociception is relieved by nanomedicine-mediated decrease of rat hippocampal tumor necrosis factor

Chronic constriction injury-induced nociception is relieved by nanomedicine-mediated decrease of rat hippocampal tumor necrosis factor

Nociception and role of immune system in pain

Cancer pain: A critical review of mechanism-based classification and physical therapy management in palliative care

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